We are analyzing https://link.springer.com/article/10.1007/s00018-022-04563-0.

Title:
Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential | Cellular and Molecular Life Sciences
Description:
Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are thought to play a vital role in disease onset. In the pathogenesis of autoimmune diseases, disturbed immunosuppressive properties of regulatory T cells contribute to the dysregulation of immune homeostasis. In RA patients, the functions of Treg cells and their frequency are reduced. Therefore, focusing on the re-establishment of self-tolerance by increasing Treg cell frequencies and preventing a loss of function is a promising strategy for the treatment of RA. This approach could be especially beneficial for those patients who do not respond well to current therapies. In this review, we summarize and discuss the current knowledge about the function, differentiation and regulation of Treg cells in RA patients and in animal models of autoimmune arthritis. In addition, we highlight the therapeutic potential as well as the challenges of Treg cell targeting treatment strategies.
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Keywords {🔍}

cells, pubmed, treg, article, google, scholar, cas, regulatory, cell, arthritis, foxp, central, immunol, patients, suppressive, autoimmune, function, mice, peripheral, rheumatoid, expression, blood, human, reported, vivo, development, immune, cdcd, clinical, transfer, effector, disease, type, role, therapy, receptor, vitro, gene, med, cytokines, activation, functions, therapeutic, inflammation, shown, tgfbeta, expansion, trials, antigenspecific, mouse,

Topics {✒️}

steroid-refractory chronic graft-versus-host-disease reduce graft-versus-host reactions cells prevent graft-versus-host-disease killed anti-coii antibody-secreting g-protein-coupled adenosine receptors single-agent cytokine/antibody fusion cell–cell contact-mediated suppression cd28/ctla-4/b7 domains plays rapamycin-based gmp-compatible process regulatory t-cell responses short-chain fatty acids alloantigen-induced cd25+cd4+ regulatory direct cell-cell contact article download pdf forkhead/winged-helix protein cell contact-mediated suppression cell contact-dependent suppression p-selectin-dependent pathways anti-cd3/cd28 beads tag single-nucleotide polymorphisms antibody-cytokine immune complexes gmp-compatible protocol employing regulatory t-cell fate good manufacturing practice-compliant antigen-specific cd4+cd25+ tgf-beta-induced foxp3+ regulatory membrane-bound il-6r myeloid-derived suppressor cells antigen-specific treg cells stem cell-derived tissue cd4+cd25highcd127lowfoxp3+ cells remain cell contact-dependent immunosuppression vivo-expanded cd4+cd25+ immunoregulatory antigen-presenting dendritic cells efficient cell-based therapy il2ra/cd25 polymorphisms contribute promote t-regulatory cells regulating post-translational modification chimeric antigen receptors human anti-il-2 antibody anti-cd3 antibodies helps future treg-based therapies chimeric antigen receptor regulatory cell-mediated suppression long-lived il-2 mutein anti-tgf-beta antibodies [52] autoantibody-mediated autoimmune disease collagen-induced treg cells regulatory t-cell function regulatory t-cell induction

Questions {❓}

Dawson NAJ, Levings MK (2017) Antigen-specific regulatory T cells: are police CARs the answer?
De Curotto Lafaille MA, Lafaille JJ (2009) Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?

Schema {🗺️}

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         description:Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are thought to play a vital role in disease onset. In the pathogenesis of autoimmune diseases, disturbed immunosuppressive properties of regulatory T cells contribute to the dysregulation of immune homeostasis. In RA patients, the functions of Treg cells and their frequency are reduced. Therefore, focusing on the re-establishment of self-tolerance by increasing Treg cell frequencies and preventing a loss of function is a promising strategy for the treatment of RA. This approach could be especially beneficial for those patients who do not respond well to current therapies. In this review, we summarize and discuss the current knowledge about the function, differentiation and regulation of Treg cells in RA patients and in animal models of autoimmune arthritis. In addition, we highlight the therapeutic potential as well as the challenges of Treg cell targeting treatment strategies.
         datePublished:2022-09-29T00:00:00Z
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      headline:Regulatory T cells in rheumatoid arthritis: functions, development, regulation, and therapeutic potential
      description:Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are thought to play a vital role in disease onset. In the pathogenesis of autoimmune diseases, disturbed immunosuppressive properties of regulatory T cells contribute to the dysregulation of immune homeostasis. In RA patients, the functions of Treg cells and their frequency are reduced. Therefore, focusing on the re-establishment of self-tolerance by increasing Treg cell frequencies and preventing a loss of function is a promising strategy for the treatment of RA. This approach could be especially beneficial for those patients who do not respond well to current therapies. In this review, we summarize and discuss the current knowledge about the function, differentiation and regulation of Treg cells in RA patients and in animal models of autoimmune arthritis. In addition, we highlight the therapeutic potential as well as the challenges of Treg cell targeting treatment strategies.
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         Regulatory T cells
         Chimeric antigen receptor
         CD4+ T cells
         Therapeutic potential
         Self-tolerance
         Autoimmunity
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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