We are analyzing https://link.springer.com/article/10.1007/s00018-022-04285-3.

Title:
WNT and NOTCH signaling in human trophoblast development and differentiation | Cellular and Molecular Life Sciences
Description:
Correct development of the human placenta and its differentiated epithelial cells, syncytial trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful pregnancy outcome. STBs develop by cell fusion of mononuclear cytotrophoblasts (CTBs) in placental floating villi, whereas migratory EVTs originate from specialized villi anchoring to the maternal decidua. Defects in trophoblast differentiation have been associated with severe pregnancy disorders such as early-onset preeclampsia and fetal growth restriction. However, the evolutionary pathways underlying normal and adverse placentation are poorly understood. Herein, we discuss Wingless (WNT) and NOTCH signaling, two pathways that play pivotal roles in human placenta and trophoblast development. Whereas WNT is necessary for expansion of trophoblast progenitors and stem cells, NOTCH1 is required for proliferation and survival of EVT precursors. Differentiation of the latter is orchestrated by a switch in NOTCH receptor expression as well as by changes in WNT ligands and their downstream effectors.
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Keywords {🔍}

pubmed, article, google, scholar, notch, cas, wnt, human, cell, trophoblast, signaling, cells, central, differentiation, placental, development, evt, placenta, expression, role, stem, protein, ligands, knöfler, progenitors, canonical, pregnancy, receptors, pollheimer, tscs, trimester, biol, evts, factor, activation, ctbs, maternal, early, tcf, pevts, proteins, proliferation, primary, expressed, wnta, pathways, expansion, suggesting, invasion, pathway,

Topics {✒️}

β-catenin-dependent tcf/lef enhanceosome semi-quantitative rt-pcr gave single-cell rna-seq profiling article download pdf ctbp c-terminal-binding protein uterine wnt/beta-catenin signaling single-cell rna-seq tcf t-cell factor c-terminal-binding protein g-protein-coupled frizzled uterine natural killer tgf-beta superfamily expression wnt/beta-catenin signalling secreted frizzled-related protein protein β-catenin serving wnt/beta-catenin signaling tsc/ctb progenitor status beta-catenin transcription activation mitogen-activated protein kinase lymphoid enhancer-binding factor paradoxical tumor-suppressor role cbp creb-binding protein /t-cell factor apical-basal cell polarity single-cell rnaseq data evt subtype-specific activation full access wnt-inactivating enzyme notum brg1 brahma-related gene-1 notch1 icd-dependent expression predominant wnt-dependent regulator histamine-degrading enzyme dao funding note blocking ligand–receptor interactions embryonic stem cells bi-layered epithelium consisting diverse cross-regulatory interactions notch-mediated cell adhesion sirna-mediated gene silencing thyroid hormone receptor membrane-bound e-cadherin cross-species meta-analysis cytoplasmic β-catenin levels membrane-bound notch ligand helix-bundle receptors interacting trophoblast lineage-specific differentiation genome size differs controls gcm1 expression activated cc-specific expression notch1 controls development

Questions {❓}

A strategy for successful endovascular invasion?
Lee CQ, Gardner L, Turco M, Zhao N, Murray MJ, Coleman N, Rossant J, Hemberger M, Moffett A (2016) What Is trophoblast?
One cause of defective endovascular invasion in this syndrome?
Part I: What do we know about formative placental development following implantation?

Schema {🗺️}

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      headline:WNT and NOTCH signaling in human trophoblast development and differentiation
      description:Correct development of the human placenta and its differentiated epithelial cells, syncytial trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful pregnancy outcome. STBs develop by cell fusion of mononuclear cytotrophoblasts (CTBs) in placental floating villi, whereas migratory EVTs originate from specialized villi anchoring to the maternal decidua. Defects in trophoblast differentiation have been associated with severe pregnancy disorders such as early-onset preeclampsia and fetal growth restriction. However, the evolutionary pathways underlying normal and adverse placentation are poorly understood. Herein, we discuss Wingless (WNT) and NOTCH signaling, two pathways that play pivotal roles in human placenta and trophoblast development. Whereas WNT is necessary for expansion of trophoblast progenitors and stem cells, NOTCH1 is required for proliferation and survival of EVT precursors. Differentiation of the latter is orchestrated by a switch in NOTCH receptor expression as well as by changes in WNT ligands and their downstream effectors.
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         NOTCH signaling
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         Life Sciences
         Biochemistry
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