We are analyzing https://link.springer.com/article/10.1007/s00018-017-2571-4.

Title:
Nuclear receptors in neural stem/progenitor cell homeostasis | Cellular and Molecular Life Sciences
Description:
In the central nervous system, embryonic and adult neural stem/progenitor cells (NSCs) generate the enormous variety and huge numbers of neuronal and glial cells that provide structural and functional support in the brain and spinal cord. Over the last decades, nuclear receptors and their natural ligands have emerged as critical regulators of NSC homeostasis during embryonic development and adult life. Furthermore, substantial progress has been achieved towards elucidating the molecular mechanisms of nuclear receptors action in proliferative and differentiation capacities of NSCs. Aberrant expression or function of nuclear receptors in NSCs also contributes to the pathogenesis of various nervous system diseases. Here, we review recent advances in our understanding of the regulatory roles of steroid, non-steroid, and orphan nuclear receptors in NSC fate decisions. These studies establish nuclear receptors as key therapeutic targets in brain diseases.
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Keywords {🔍}

pubmed, google, scholar, cas, article, receptor, central, cell, nuclear, cells, stem, neural, receptors, adult, mol, neurosci, brain, differentiation, development, thyroid, hormone, biol, expression, orphan, neurogenesis, factor, retinoic, acid, neurons, tlx, res, dev, signaling, embryonic, glucocorticoid, sci, endocrinol, rat, proliferation, mouse, nurr, hippocampal, gene, function, neuronal, vitamin, regulates, disease, usa, estrogen,

Topics {✒️}

peroxisome proliferator-activated receptor-gamma peroxisome proliferator-activated receptor-alpha canonical wnt/beta-catenin regulation month download article/chapter amyloid-beta-induced mitochondrial dysfunction nuclear-receptor-dependent phosphatidylcholine pathway peroxisome proliferator-activated receptors retinoic acid-mediated regulation cell-specific nuclear receptor neural stem/progenitor cells oxysterol-activated nuclear receptors thyroid hormone-otx2 signaling impairs fear-motivated behavior bcl-2 anti-apoptotic protein ftz-f1 disrupted mice gr-dependent signaling pathway lipid-activated nuclear receptors 39-triiodo-l-thyronine t4 de kloet er vitamin d-mediated transcription long-term potentiation alleviating glucocorticoid-induced inhibition adult hippocampal progenitors hypothalamus–pituitary–adrenals ipscs generating tissue-specific actions beta-catenin signaling central nervous system estrogen-receptor-dependent regulation transcription factors coup-tfi nuclear receptor nr5a2 nsc fate decisions de rijk rh retinoic acid signaling dexamethasone inhibits proliferation orphan nuclear receptor induces mitochondrial stabilization neural stem cell full article pdf area-specific temporal control retinoic acid receptors thyroid hormone receptor early neural lineage ppargamma-dependent pathways transcription factor tailless 9-cis retinoic acid hippocampal cell proliferation high-dose corticosteroids neural stem cells nuclear receptor tailless nuclear receptor tlx

Questions {❓}

Bjorkhem I (2009) Are side-chain oxidized oxysterols regulators also in vivo?
Mey J (2006) New therapeutic target for CNS injury?
Overington JP, Al-Lazikani B, Hopkins AL (2006) How many drug targets are there?
Viennois E et al (2011) Targeting liver X receptors in human health: deadlock or promising trail?

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