We are analyzing https://link.springer.com/article/10.1007/s00018-014-1817-7.

Title:
Mammary lineage tracing: the coming of age | Cellular and Molecular Life Sciences
Description:
Identification and characterization of the normal epithelial lineages in the mammary gland is a fundamental step in understanding both development and cellular origin of cancer. In contrast to other tissues where lineage tracing has been widely accepted as a method of choice for dissecting the stem cell hierarchy, mammary gland has long remained a challenge due to its unique developmental and topological features. Recent advances in high-resolution single-cell imaging, combined with the use of inducible Cre-recombinase and in situ cell ablation, have provided unprecedented insight into mammary epithelial cell composition and function. Here, we briefly summarize and compare different mammary gland lineage tracing strategies, examine associated caveats and discuss future challenges and opportunities.
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Keywords {🔍}

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Topics {✒️}

wnt/beta-catenin-responsive stem cells cell-type-specific cre-expressing adenoviruses high-resolution single-cell imaging month download article/chapter single stem cell developmental stage-specific contribution related subjects luminal epithelial lineages full article pdf mammary stem cells multipotent mammary progenitor mammary epithelial cells mouse mammary gland normal epithelial lineages regan jl bipotent stem cells luminal cell hierarchy mammary lineage tracing article sale postnatal mammary gland pregnancy-specific activity privacy choices/manage cookies van kappel ec sanja sale lgr5-expressing cells mammary gland epithelium stem cell hierarchy human breast cancer functional mammary gland inducible cre-recombinase estrogen receptor expression single cell situ cell ablation targeted cell ablation gene expression signatures developmental lineage relationships distinct cellular progenitors cell size enriches mammary cellular hierarchy mammary gland development article cellular european economic area provided unprecedented insight discuss future challenges asselin-labat ml van bragt mp zeng ya stem cells 31 check access instant access

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         description:Identification and characterization of the normal epithelial lineages in the mammary gland is a fundamental step in understanding both development and cellular origin of cancer. In contrast to other tissues where lineage tracing has been widely accepted as a method of choice for dissecting the stem cell hierarchy, mammary gland has long remained a challenge due to its unique developmental and topological features. Recent advances in high-resolution single-cell imaging, combined with the use of inducible Cre-recombinase and in situ cell ablation, have provided unprecedented insight into mammary epithelial cell composition and function. Here, we briefly summarize and compare different mammary gland lineage tracing strategies, examine associated caveats and discuss future challenges and opportunities.
         datePublished:2015-01-07T00:00:00Z
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      headline:Mammary lineage tracing: the coming of age
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         Lineages
         Fate mapping
         In situ cell ablation
         Cell-of-origin
         Genetically engineered mouse models
         Topological context
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         Biomedicine
         general
         Life Sciences
         Biochemistry
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