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Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells | Cellular and Molecular Life Sciences
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Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.
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Topics {✒️}
month download article/chapter neural stem/progenitor cells radial glial cells fgf-2-stimulated neural progenitors jean-leon thomas slit/robo signaling modulates groupe hospitalier pitié-salpètrière niche cell–cell interactions ruiz de almodovar regulating notch-dependent neurogenesis notch-dependent vegfr3 upregulation brain lipid-binding protein neural stem cells cell fate control neural progenitor cells collège de france wnt1 regulates neurogenesis extracellular matrix molecules endothelial cell interactions regulate neurogenic divisions full article pdf regulate retinal neurogenesis adult subventricular zone article cellular charles calvo tip cell position receptor tyrosine kinases vascular network formation vegfr-3 controls tip multiple human tissues endothelial cells stimulate modulates cell migration endothelial cell adhesion pathology haartman institute notch signalling pathway privacy choices/manage cookies p53-dependent pathway foxc2 transcription factor specialized vascular niche notch signaling pathway european economic area flk-1-deficient mice postnatal mouse brain notch1 regulates formation adult hippocampal neurogenesis vegfc/flt4 signalling common growth factors shared growth factors endothelial cell differentiation rbpjkappa-dependent signaling
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headline:Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
description:Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.
datePublished:2013-03-12T00:00:00Z
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Angiogenesis
Neurogenesis
Neurovascular interactions
Notch
VEGFs
VEGFRs
Cell Biology
Biomedicine
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Life Sciences
Biochemistry
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headline:Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells
description:Notch cell interaction mechanism governs cell fate decisions in many different cell contexts throughout the lifetime of all Metazoan species. It links the fate of one cell to that of its neighbors through cell-to-cell contacts, and binding of Notch receptors expressed on one cell to their membrane bound ligands on an adjacent cell. Environmental cues, such as growth factors and extracellular matrix molecules, superimpose a dynamic regulation on this canonical Notch signaling pathway. In this review, we will focus on Notch signaling in the vertebrate vascular and nervous systems and examine its role in angiogenesis, neurogenesis, and neurovascular interactions. We will also highlight the molecular relationships of the Notch pathway with vascular endothelial growth factors (VEGFs) and their high-affinity tyrosine kinase VEGF receptors, key regulators of both angiogenesis and neurogenesis.
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Neurogenesis
Neurovascular interactions
Notch
VEGFs
VEGFRs
Cell Biology
Biomedicine
general
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Biochemistry
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