We are analyzing https://link.springer.com/article/10.1007/s00018-012-1028-z.

Title:
Voices from within: gut microbes and the CNS | Cellular and Molecular Life Sciences
Description:
Recent advances in research have greatly increased our understanding of the importance of the gut microbiota. Bacterial colonization of the intestine is critical to the normal development of many aspects of physiology such as the immune and endocrine systems. It is emerging that the influence of the gut microbiota also extends to modulation of host neural development. Furthermore, the overall balance in composition of the microbiota, together with the influence of pivotal species that induce specific responses, can modulate adult neural function, peripherally and centrally. Effects of commensal gut bacteria in adult animals include protection from the central effects of infection and inflammation as well as modulation of normal behavioral responses. There is now robust evidence that gut bacteria influence the enteric nervous system, an effect that may contribute to afferent signaling to the brain. The vagus nerve has also emerged as an important means of communicating signals from gut bacteria to the CNS. Further understanding of the mechanisms underlying microbiome–gut–brain communication will provide us with new insight into the symbiotic relationship between gut microbiota and their mammalian hosts and help us identify the potential for microbial-based therapeutic strategies to aid in the treatment of mood disorders.
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Keywords {🔍}

google, scholar, article, pubmed, cas, gut, brain, mice, effects, role, physiol, sci, bacteria, microbiota, res, system, intestinal, wang, lactobacillus, forsythe, human, probiotic, neurosci, receptor, acad, usa, neural, nerve, med, proc, natl, kunze, enteric, rev, behav, behavior, intestine, central, nervous, effect, afferent, gastrointestinal, psychiatry, rat, function, content, microbes, immune, modulation, responses,

Topics {✒️}

hypothalamic–pituitary–adrenocortical axis responses enteric nervous system month download article/chapter microbial-based therapeutic strategies hypothalamic–pituitary–adrenal system brain-derived neurotrophic factor brain-derived neurotropic factor cat oesophago-gastric junction neurotoxin-exerted apoptotic death running-induced hippocampal neurogenesis diet-induced mating preference gastrin-releasing peptide receptor lactobacillus plantarum-mediated protection quantitative micro-anatomical study placebo-controlled pilot study hypothalamic-pituitary-adrenal axis lethal intestinal pseudo-obstruction stress-induced memory dysfunction streptozotocin-induced diabetic mice lactic-acid producing bacteria appetite-regulating peptide hormones gh-secretagogue-receptor modulation gal-r1 knockout mice full article pdf central autonomic pathways visceral pain induced corticotropin-releasing factor privacy choices/manage cookies bifidobacterium longum r0175 normal intestinal microbiota hypothalamus–pituitary–adrenal human enteric nerves fear-related behaviour display elevated preference probiotic bifidobacterium infantis visceral pain perception lactobacillus johnsonii la1 lactobacillus helveticus r0052 induce specific responses muscarinic receptor activation ben abdallah nm wrenn cc gal-r1 subtype central neurochemical change article forsythe feeding lactobacillus delbrueckii article cellular gender-dependent modulation long-term memory vago-vagal reflexes

Questions {❓}

Browning KN, Mendelowitz D (2003) Musings on the wanderer: what’s new in our understanding of vago-vagal reflexes?
Cameron J, Doucet E (2007) Getting to the bottom of feeding behaviour: who’s on top?
Craig AD (2002) How do you feel?
Craig AD (2009) How do you feel—now?
Dantzer R, Konsman JP, Bluthe RM, Kelley KW (2000) Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?
Iyer LM, Aravind L, Coon SL, Klein DC, Koonin EV (2004) Evolution of cell–cell signaling in animals: did late horizontal gene transfer from bacteria have a role?
Tehrani AB, Nezami BG, Gewirtz A, Srinivasan S (2012) Obesity and its associated disease: a role for microbiota?
Zagon A (2001) Does the vagus nerve mediate the sixth sense?

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