We are analyzing https://link.springer.com/article/10.1007/s00018-011-0834-z.

Title:
Inflammation and repeated infections in CGD: two sides of a coin | Cellular and Molecular Life Sciences
Description:
Chronic granulomatous disease (CGD) is an uncommon congenital immunodeficiency seen approximately in 1 of 250,000 individuals. It is caused by a profound defect in a burst of oxygen consumption that normally accompanies phagocytosis in all myeloid cells (neutrophils, eosinophils, monocytes, and macrophages). This “respiratory burst” involves the catalytic conversion of molecular oxygen to the oxygen free-radical superoxide, which in turn gives rise to hydrogen peroxide, hypochlorous acid, and hydroxyl radicals. These oxygen derivatives play a critical role in the killing of pathogenic bacteria and fungi. As a result of the failure to activate the respiratory burst in their phagocytes, the majority of CGD patients suffer from severe recurrent infections and rather unexplained prolonged inflammatory reactions that may result in granulomatous lesions. Both may cause severe organ dysfunction depending on the tissues involved. Preventive measures as well as rapid (invasive) diagnostic procedures are required to successfully treat CGD. Hematopoietic stem cell transplantation may be a serious option in some of the patients.
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Keywords {🔍}

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Topics {✒️}

autosomal-dominant hyper-ige syndrome cd4 + cd25 + antigen-specific regulatory vitro-expanded antigen-specific regulatory article download pdf ido-mediated l-tryptophan metabolism cd4 + cd25 + foxp3 + chronic granulomatous disease catalase-deficient aspergillus nidulans augmented nf-κb activation gp 91phox-deficient patients th2 cell-signaling pathways hyper-ige syndrome l-kynurenine suppletion restores natural l-kynurenine distal oxygen free-radical superoxide amino acid l-tryptophan full size image constitutively express il-17r inadequate anti-microbial defense increased nf-κb activation ido converts l-tryptophan zymosan-induced lung inflammation inadequate anti-microbial response ifn-γ amplifies il-6 membrane-bound tgf-β [51] ido product l-kynurenine ido-generated l-kynurenine ifn-γ-exposed monocytes il-17-mediated immune pathway drive chronic inflammation reactive oxygen species van der loos van der poll redox-mediated signaling tight junction proteins privacy choices/manage cookies exaggerated inflammatory responses gp91phox-negative dendritic cells promote chronic inflammation nadph oxidase-deficient p47phox-mutated background innate il-17-producing cells inflammatory immune responses anti-inflammatory agent activate tgf-β exaggerated inflammatory response regulatory pathways exist develop autoimmune diseases tryptophan/kynurenine metabolism anti-inflammatory macrophages

Schema {🗺️}

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         headline:Inflammation and repeated infections in CGD: two sides of a coin
         description:Chronic granulomatous disease (CGD) is an uncommon congenital immunodeficiency seen approximately in 1 of 250,000 individuals. It is caused by a profound defect in a burst of oxygen consumption that normally accompanies phagocytosis in all myeloid cells (neutrophils, eosinophils, monocytes, and macrophages). This “respiratory burst” involves the catalytic conversion of molecular oxygen to the oxygen free-radical superoxide, which in turn gives rise to hydrogen peroxide, hypochlorous acid, and hydroxyl radicals. These oxygen derivatives play a critical role in the killing of pathogenic bacteria and fungi. As a result of the failure to activate the respiratory burst in their phagocytes, the majority of CGD patients suffer from severe recurrent infections and rather unexplained prolonged inflammatory reactions that may result in granulomatous lesions. Both may cause severe organ dysfunction depending on the tissues involved. Preventive measures as well as rapid (invasive) diagnostic procedures are required to successfully treat CGD. Hematopoietic stem cell transplantation may be a serious option in some of the patients.
         datePublished:2011-11-15T00:00:00Z
         dateModified:2011-11-15T00:00:00Z
         pageStart:7
         pageEnd:15
         license:https://creativecommons.org/licenses/by-nc/2.0
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            Granuloma
            NADPH oxidase
            IDO
            Tryptophan
            Kynurenine
            IL-17
            Tregs
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
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ScholarlyArticle:
      headline:Inflammation and repeated infections in CGD: two sides of a coin
      description:Chronic granulomatous disease (CGD) is an uncommon congenital immunodeficiency seen approximately in 1 of 250,000 individuals. It is caused by a profound defect in a burst of oxygen consumption that normally accompanies phagocytosis in all myeloid cells (neutrophils, eosinophils, monocytes, and macrophages). This “respiratory burst” involves the catalytic conversion of molecular oxygen to the oxygen free-radical superoxide, which in turn gives rise to hydrogen peroxide, hypochlorous acid, and hydroxyl radicals. These oxygen derivatives play a critical role in the killing of pathogenic bacteria and fungi. As a result of the failure to activate the respiratory burst in their phagocytes, the majority of CGD patients suffer from severe recurrent infections and rather unexplained prolonged inflammatory reactions that may result in granulomatous lesions. Both may cause severe organ dysfunction depending on the tissues involved. Preventive measures as well as rapid (invasive) diagnostic procedures are required to successfully treat CGD. Hematopoietic stem cell transplantation may be a serious option in some of the patients.
      datePublished:2011-11-15T00:00:00Z
      dateModified:2011-11-15T00:00:00Z
      pageStart:7
      pageEnd:15
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s00018-011-0834-z
      keywords:
         Infection
         Inflammation
         Granuloma
         NADPH oxidase
         IDO
         Tryptophan
         Kynurenine
         IL-17
         Tregs
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-011-0834-z/MediaObjects/18_2011_834_Fig3_HTML.jpg
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                     type:PostalAddress
                  type:Organization
                  name:University of Amsterdam
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                     name:Sanquin Research and Landsteiner Laboratory AMC, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands
                     type:PostalAddress
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         type:PostalAddress
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      address:
         name:AMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
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      address:
         name:AMC, Department of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands
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               name:Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:University of Amsterdam
            address:
               name:Sanquin Research and Landsteiner Laboratory AMC, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Rene Lutter
      affiliation:
            name:University of Amsterdam
            address:
               name:AMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:University of Amsterdam
            address:
               name:AMC, Department of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands
      name:Sanquin Research and Landsteiner Laboratory AMC, Department of Blood Cell Research, University of Amsterdam, Amsterdam, The Netherlands
      name:AMC, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
      name:AMC, Department of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands

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