We are analyzing https://link.springer.com/article/10.1007/s00018-010-0565-6.

Title:
Chaperone-mediated autophagy: machinery, regulation and biological consequences | Cellular and Molecular Life Sciences
Description:
Degradation of dysfunctional intracellular components in the lysosome system can occur through three different pathways, i.e., macroautophagy, microautophagy and chaperone-mediated autophagy (CMA). In this review, we focus on CMA, a type of autophagy distinct from the other two autophagic pathways owing to its selectivity, saturability and competitivity by which a subset of long-lived cytosolic soluble proteins are directly delivered into the lysosomal lumen via specific receptors. CMA participates in quality control to maintain normal cell functions by clearing “old” proteins and provides energy to cells under nutritional stress. Deregulation of CMA has recently been shown to underlie some diseases, especially neurodegenerative disorders for which the decline with age in the activity of CMA may become a major aggravating factor. Therefore, targeting aberrant alteration in CMA under pathological conditions could serve as a potential therapeutic strategy for treating related diseases.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,625,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

google, scholar, pubmed, cas, autophagy, chaperonemediated, cuervo, biol, cell, dice, degradation, chem, lysosomal, mol, proteins, selective, protein, article, kaushik, mao, molecular, pathways, cma, disease, cellular, regulation, lysosome, factor, wang, lysosomes, mechanisms, ubiquitin, biochem, nat, sci, membrane, massey, privacy, cookies, content, macroautophagy, functions, cells, role, saftig, nature, knecht, alphasynuclein, kiffin, function,

Topics {✒️}

lamp-1/lamp-2 double-deficient fibroblasts month download article/chapter qian yang & zixu mao abnormal chaperone-mediated autophagy harnessing chaperone-mediated autophagy chaperone-mediated autophagy depends regulates chaperone-mediated autophagy stress-regulated cochaperone aha1 chaperone-assisted selective autophagy lamp-2-deficient mice myocyte-enhancer factor 2 potential therapeutic strategy privacy choices/manage cookies mutant alpha-synuclein camp-protein kinase transcription factor mef2 chaperone carboxyl terminus full article pdf ubiquitin ligase complexes autophagy-lysosomal degradation pathway manning-bog ab chaperone-mediated autophagy chaperone mediated autophagy neurotoxicity-induced apoptosis chemically induced nephropathy senescent human fibroblasts mutant uch-l1 molecular chaperone complex ubiquitin-mediated recognition chaperone-assisted degradation major aggravating factor nucleotide exchange factor cdk5-mediated inhibition related subjects eskelinen el autophagy-lysosome systems european economic area glyceraldehyde-3-phosphate dehydrogenase auxilindynamin interactions link uncouples nucleotide hydrolysis peptide sequences related di monte da ikk phosphorylates huntingtin acute diabetes mellitus fox foundation grant emory university school protein half-lives dynamic protein complexes mutant huntingtin protein normal proteolytic function

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Chaperone-mediated autophagy: machinery, regulation and biological consequences
         description:Degradation of dysfunctional intracellular components in the lysosome system can occur through three different pathways, i.e., macroautophagy, microautophagy and chaperone-mediated autophagy (CMA). In this review, we focus on CMA, a type of autophagy distinct from the other two autophagic pathways owing to its selectivity, saturability and competitivity by which a subset of long-lived cytosolic soluble proteins are directly delivered into the lysosomal lumen via specific receptors. CMA participates in quality control to maintain normal cell functions by clearing “old” proteins and provides energy to cells under nutritional stress. Deregulation of CMA has recently been shown to underlie some diseases, especially neurodegenerative disorders for which the decline with age in the activity of CMA may become a major aggravating factor. Therefore, targeting aberrant alteration in CMA under pathological conditions could serve as a potential therapeutic strategy for treating related diseases.
         datePublished:2010-10-26T00:00:00Z
         dateModified:2010-10-26T00:00:00Z
         pageStart:749
         pageEnd:763
         sameAs:https://doi.org/10.1007/s00018-010-0565-6
         keywords:
            CMA
            Lysosome
            Hsc70
            Lamp2a
            Autophagy
            Unibiquitin
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-010-0565-6/MediaObjects/18_2010_565_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-010-0565-6/MediaObjects/18_2010_565_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-010-0565-6/MediaObjects/18_2010_565_Fig3_HTML.gif
         isPartOf:
            name:Cellular and Molecular Life Sciences
            issn:
               1420-9071
               1420-682X
            volumeNumber:68
            type:
               Periodical
               PublicationVolume
         publisher:
            name:SP Birkhäuser Verlag Basel
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Wenming Li
               affiliation:
                     name:Emory University School of Medicine
                     address:
                        name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qian Yang
               affiliation:
                     name:Emory University School of Medicine
                     address:
                        name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zixu Mao
               affiliation:
                     name:Emory University School of Medicine
                     address:
                        name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Chaperone-mediated autophagy: machinery, regulation and biological consequences
      description:Degradation of dysfunctional intracellular components in the lysosome system can occur through three different pathways, i.e., macroautophagy, microautophagy and chaperone-mediated autophagy (CMA). In this review, we focus on CMA, a type of autophagy distinct from the other two autophagic pathways owing to its selectivity, saturability and competitivity by which a subset of long-lived cytosolic soluble proteins are directly delivered into the lysosomal lumen via specific receptors. CMA participates in quality control to maintain normal cell functions by clearing “old” proteins and provides energy to cells under nutritional stress. Deregulation of CMA has recently been shown to underlie some diseases, especially neurodegenerative disorders for which the decline with age in the activity of CMA may become a major aggravating factor. Therefore, targeting aberrant alteration in CMA under pathological conditions could serve as a potential therapeutic strategy for treating related diseases.
      datePublished:2010-10-26T00:00:00Z
      dateModified:2010-10-26T00:00:00Z
      pageStart:749
      pageEnd:763
      sameAs:https://doi.org/10.1007/s00018-010-0565-6
      keywords:
         CMA
         Lysosome
         Hsc70
         Lamp2a
         Autophagy
         Unibiquitin
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-010-0565-6/MediaObjects/18_2010_565_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-010-0565-6/MediaObjects/18_2010_565_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-010-0565-6/MediaObjects/18_2010_565_Fig3_HTML.gif
      isPartOf:
         name:Cellular and Molecular Life Sciences
         issn:
            1420-9071
            1420-682X
         volumeNumber:68
         type:
            Periodical
            PublicationVolume
      publisher:
         name:SP Birkhäuser Verlag Basel
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Wenming Li
            affiliation:
                  name:Emory University School of Medicine
                  address:
                     name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qian Yang
            affiliation:
                  name:Emory University School of Medicine
                  address:
                     name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zixu Mao
            affiliation:
                  name:Emory University School of Medicine
                  address:
                     name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Life Sciences
      issn:
         1420-9071
         1420-682X
      volumeNumber:68
Organization:
      name:SP Birkhäuser Verlag Basel
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Emory University School of Medicine
      address:
         name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
         type:PostalAddress
      name:Emory University School of Medicine
      address:
         name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
         type:PostalAddress
      name:Emory University School of Medicine
      address:
         name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Wenming Li
      affiliation:
            name:Emory University School of Medicine
            address:
               name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
               type:PostalAddress
            type:Organization
      name:Qian Yang
      affiliation:
            name:Emory University School of Medicine
            address:
               name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
               type:PostalAddress
            type:Organization
      name:Zixu Mao
      affiliation:
            name:Emory University School of Medicine
            address:
               name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
      name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
      name:Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(229)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.81s.

LINK . SPRINGER . COM {}