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Title:
The multiple roles of monocyte subsets in steady state and inflammation | Cellular and Molecular Life Sciences
Description:
Monocytes participate importantly in immunity. Produced in the bone marrow and released into the blood, they circulate in blood or reside in a spleen reservoir before entering tissue and giving rise to macrophages or dendritic cells. Monocytes are more than transitional cells that adapt to a particular tissue environment indiscriminately. Accumulating evidence now indicates that monocytes are heterogeneous in several species and are themselves predetermined for particular function in the steady state and inflammation. Future therapeutics may harness this heterogeneity to target harmful functions while sparing those that are beneficial. Here, we review recent advances on the ontogeny and function of monocytes and their subsets in humans and mice.
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Topics {✒️}

b220-cd11b+ly-6c+ dendritic cells tnf/inos-producing dendritic cells antigen-activated cd4-positive cytotoxic month download article/chapter proinflammatory cd14 + cd16 + dr++ monocytes p-selectin glycoprotein ligand-1 hypertension-induced vascular inflammation ly-6chi monocyte recruitment innate immune responses monocyte-mediated defense ziegler-heitbrock hw full article pdf hematopoietic stem cells listeria monocytogenes infection myeloid progenitor capable tnf/roi+ phagocytes viral antigen-induced serbina nv grage-griebenow ly-6chi monocytes privacy choices/manage cookies related subjects ziegler-heitbrock lh simches research building conventional dendritic cells human monocyte subpopulations cd14+ cd16+ monocytes human monocyte subsets ly-6chiccr2+ monocytes tumor-bearing host human peripheral blood mouse monocyte subsets migratory dendritic cells human mo subsets differential interleukin-1 elaboration sequential myd88-independent blood monocyte subsets independent chemokine functions peripheral lymphoid organs atherosclerotic lesion formation human monocytes preferentially distinct monocyte subsets article cellular fractalkine receptor cx lymphocyte subsets obtained thermal injury elevates t-cell anergy counterflow centrifugation elutriation chemokine receptor ccr2 gene expression profiles

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         description:Monocytes participate importantly in immunity. Produced in the bone marrow and released into the blood, they circulate in blood or reside in a spleen reservoir before entering tissue and giving rise to macrophages or dendritic cells. Monocytes are more than transitional cells that adapt to a particular tissue environment indiscriminately. Accumulating evidence now indicates that monocytes are heterogeneous in several species and are themselves predetermined for particular function in the steady state and inflammation. Future therapeutics may harness this heterogeneity to target harmful functions while sparing those that are beneficial. Here, we review recent advances on the ontogeny and function of monocytes and their subsets in humans and mice.
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