We are analyzing https://link.springer.com/article/10.1007/s00018-009-0210-4.

Title:
Platelets in defense against bacterial pathogens | Cellular and Molecular Life Sciences
Description:
Platelets interact with bacterial pathogens through a wide array of cellular and molecular mechanisms. The consequences of this interaction may significantly influence the balance between infection and immunity. On the one hand, recent data indicate that certain bacteria may be capable of exploiting these interactions to gain a virulence advantage. Indeed, certain bacterial pathogens appear to have evolved specific ways in which to subvert activated platelets. Hence, it is conceivable that some bacterial pathogens exploit platelet responses. On the other hand, platelets are now known to possess unambiguous structures and functions of host defense effector cells. Recent discoveries emphasize critical features enabling such functions, including expression of toll-like receptors that detect hallmark signals of bacterial infection, an array of microbicidal peptides, as well as other host defense molecules and functions. These concepts are consistent with increased risk and severity of bacterial infection as correlates of clinical abnormalities in platelet quantity and quality. In these respects, the molecular and cellular roles of platelets in host defense against bacterial pathogens are explored with attention on advances in platelet immunobiology.
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Keywords {🔍}

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Schema {🗺️}

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         headline:Platelets in defense against bacterial pathogens
         description:Platelets interact with bacterial pathogens through a wide array of cellular and molecular mechanisms. The consequences of this interaction may significantly influence the balance between infection and immunity. On the one hand, recent data indicate that certain bacteria may be capable of exploiting these interactions to gain a virulence advantage. Indeed, certain bacterial pathogens appear to have evolved specific ways in which to subvert activated platelets. Hence, it is conceivable that some bacterial pathogens exploit platelet responses. On the other hand, platelets are now known to possess unambiguous structures and functions of host defense effector cells. Recent discoveries emphasize critical features enabling such functions, including expression of toll-like receptors that detect hallmark signals of bacterial infection, an array of microbicidal peptides, as well as other host defense molecules and functions. These concepts are consistent with increased risk and severity of bacterial infection as correlates of clinical abnormalities in platelet quantity and quality. In these respects, the molecular and cellular roles of platelets in host defense against bacterial pathogens are explored with attention on advances in platelet immunobiology.
         datePublished:2009-12-15T00:00:00Z
         dateModified:2009-12-15T00:00:00Z
         pageStart:525
         pageEnd:544
         license:https://creativecommons.org/licenses/by-nc/2.0
         sameAs:https://doi.org/10.1007/s00018-009-0210-4
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            Platelets
            Host defenses
            Bacteria
            Pathogen
            Interactions
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
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ScholarlyArticle:
      headline:Platelets in defense against bacterial pathogens
      description:Platelets interact with bacterial pathogens through a wide array of cellular and molecular mechanisms. The consequences of this interaction may significantly influence the balance between infection and immunity. On the one hand, recent data indicate that certain bacteria may be capable of exploiting these interactions to gain a virulence advantage. Indeed, certain bacterial pathogens appear to have evolved specific ways in which to subvert activated platelets. Hence, it is conceivable that some bacterial pathogens exploit platelet responses. On the other hand, platelets are now known to possess unambiguous structures and functions of host defense effector cells. Recent discoveries emphasize critical features enabling such functions, including expression of toll-like receptors that detect hallmark signals of bacterial infection, an array of microbicidal peptides, as well as other host defense molecules and functions. These concepts are consistent with increased risk and severity of bacterial infection as correlates of clinical abnormalities in platelet quantity and quality. In these respects, the molecular and cellular roles of platelets in host defense against bacterial pathogens are explored with attention on advances in platelet immunobiology.
      datePublished:2009-12-15T00:00:00Z
      dateModified:2009-12-15T00:00:00Z
      pageStart:525
      pageEnd:544
      license:https://creativecommons.org/licenses/by-nc/2.0
      sameAs:https://doi.org/10.1007/s00018-009-0210-4
      keywords:
         Platelets
         Host defenses
         Bacteria
         Pathogen
         Interactions
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00018-009-0210-4/MediaObjects/18_2009_210_Fig1_HTML.gif
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            affiliation:
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      name:SP Birkhäuser Verlag Basel
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:David Geffen School of Medicine at UCLA
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         name:Division of Infectious Diseases, St. John’s Cardiovascular Research Center, Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, USA
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      affiliation:
            name:David Geffen School of Medicine at UCLA
            address:
               name:Division of Infectious Diseases, St. John’s Cardiovascular Research Center, Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, USA
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      email:[email protected]
PostalAddress:
      name:Division of Infectious Diseases, St. John’s Cardiovascular Research Center, Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, USA

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