We are analyzing https://link.springer.com/article/10.1007/s00018-008-7496-5.

Title:
Cholera toxin structure, gene regulation and pathophysiological and immunological aspects | Cellular and Molecular Life Sciences
Description:
Many notions regarding the function, structure and regulation of cholera toxin expression have remained essentially unaltered in the last 15 years. At the same time, recent findings have generated additional perspectives. For example, the cholera toxin genes are now known to be carried by a non-lytic bacteriophage, a previously unsuspected condition. Understanding of how the expression of cholera toxin genes is controlled by the bacterium at the molecular level has advanced significantly and relationships with cell-density-associated (quorum-sensing) responses have recently been discovered. Regarding the cell intoxication process, the mode of entry and intracellular transport of cholera toxin are becoming clearer. In the immunological field, the strong oral immunogenicity of the non-toxic B subunit of cholera toxin (CTB) has been exploited in the development of a now widely licensed oral cholera vaccine. Additionally, CTB has been shown to induce tolerance against co-administered (linked) foreign antigens in some autoimmune and allergic diseases.
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

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         headline:Cholera toxin structure, gene regulation and pathophysiological and immunological aspects
         description:Many notions regarding the function, structure and regulation of cholera toxin expression have remained essentially unaltered in the last 15 years. At the same time, recent findings have generated additional perspectives. For example, the cholera toxin genes are now known to be carried by a non-lytic bacteriophage, a previously unsuspected condition. Understanding of how the expression of cholera toxin genes is controlled by the bacterium at the molecular level has advanced significantly and relationships with cell-density-associated (quorum-sensing) responses have recently been discovered. Regarding the cell intoxication process, the mode of entry and intracellular transport of cholera toxin are becoming clearer. In the immunological field, the strong oral immunogenicity of the non-toxic B subunit of cholera toxin (CTB) has been exploited in the development of a now widely licensed oral cholera vaccine. Additionally, CTB has been shown to induce tolerance against co-administered (linked) foreign antigens in some autoimmune and allergic diseases.
         datePublished:2008-02-19T00:00:00Z
         dateModified:2008-02-19T00:00:00Z
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            GM1 binding site
            virulence gene regulation
            toxin secretion
            intracellular toxin traffic
            immunotolerance induction
            allergy treatment
            autoimmune disease
            oral cholera vaccine
            Cell Biology
            Biomedicine
            general
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            Biochemistry
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      headline:Cholera toxin structure, gene regulation and pathophysiological and immunological aspects
      description:Many notions regarding the function, structure and regulation of cholera toxin expression have remained essentially unaltered in the last 15 years. At the same time, recent findings have generated additional perspectives. For example, the cholera toxin genes are now known to be carried by a non-lytic bacteriophage, a previously unsuspected condition. Understanding of how the expression of cholera toxin genes is controlled by the bacterium at the molecular level has advanced significantly and relationships with cell-density-associated (quorum-sensing) responses have recently been discovered. Regarding the cell intoxication process, the mode of entry and intracellular transport of cholera toxin are becoming clearer. In the immunological field, the strong oral immunogenicity of the non-toxic B subunit of cholera toxin (CTB) has been exploited in the development of a now widely licensed oral cholera vaccine. Additionally, CTB has been shown to induce tolerance against co-administered (linked) foreign antigens in some autoimmune and allergic diseases.
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      dateModified:2008-02-19T00:00:00Z
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      pageEnd:1360
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         GM1 binding site
         virulence gene regulation
         toxin secretion
         intracellular toxin traffic
         immunotolerance induction
         allergy treatment
         autoimmune disease
         oral cholera vaccine
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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