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Endocannabinoids in adipocytes during differentiation and their role in glucose uptake | Cellular and Molecular Life Sciences
Description:
The molecular basis for the control of energy balance by the endocannabinoid anandamide (AEA) is still unclear. Here, we show that murine 3T3-L1 fibroblasts have the machinery to bind, synthesize and degrade AEA, and that their differentiation into adipocytes increases by approximately twofold the binding efficiency of cannabinoid receptors (CBR), and by approximately twofold and approximately threefold, respectively, the catalytic efficiency of the AEA transporter and AEA hydrolase. In contrast, the activity of the AEA synthetase and the binding efficiency of vanilloid receptor were not affected by the differentiation process. In addition, we demonstrate that AEA increases by approximately twofold insulin-stimulated glucose uptake in differentiated adipocytes, according to a CB1R-dependent mechanism that involves nitric oxide synthase, but not lipoxygenase or cyclooxygenase. We also show that AEA binding to peroxisome proliferator-activated receptor-γ, known to induce differentiation of 3T3-L1 fibroblasts into adipocytes, is not involved in the stimulation of glucose uptake.
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article, aea, adipocytes, differentiation, privacy, cookies, content, research, glucose, fezza, information, publish, search, sciences, endocannabinoids, uptake, maccarrone, approximately, access, data, log, journal, molecular, life, gasperi, pasquariello, oddi, energy, endocannabinoid, twofold, binding, efficiency, cell, chapter, november, discover, author, italy, rome, springer, optional, personal, parties, european, policy, find, track, cellular, role, published,
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peroxisome proliferator-activated receptor-γ month download article/chapter murine 3t3-l1 fibroblasts cb1r-dependent mechanism privacy choices/manage cookies 3t3-l1 fibroblasts full article pdf related subjects energy balance european economic area scope submit manuscript glucose uptake conditions privacy policy accepting optional cookies vanilloid receptor rome ‘tor vergata main content log check access instant access fezza equally contributed journal finder publish article cellular endocannabinoid anandamide endocannabinoid degradation pre-clinical 1007/s00018-006-6445-4 keywords brain research approximately twofold finazzi agrò privacy policy personal data molecular basis life sci article log books a author correspondence biomedical sciences biochemical sciences article cite optional cookies manage preferences approximately threefold differentiation process induce differentiation article gasperi adipocytes increases differentiated adipocytes data protection essential cookies cookies skip
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headline:Endocannabinoids in adipocytes during differentiation and their role in glucose uptake
description:The molecular basis for the control of energy balance by the endocannabinoid anandamide (AEA) is still unclear. Here, we show that murine 3T3-L1 fibroblasts have the machinery to bind, synthesize and degrade AEA, and that their differentiation into adipocytes increases by approximately twofold the binding efficiency of cannabinoid receptors (CBR), and by approximately twofold and approximately threefold, respectively, the catalytic efficiency of the AEA transporter and AEA hydrolase. In contrast, the activity of the AEA synthetase and the binding efficiency of vanilloid receptor were not affected by the differentiation process. In addition, we demonstrate that AEA increases by approximately twofold insulin-stimulated glucose uptake in differentiated adipocytes, according to a CB1R-dependent mechanism that involves nitric oxide synthase, but not lipoxygenase or cyclooxygenase. We also show that AEA binding to peroxisome proliferator-activated receptor-γ, known to induce differentiation of 3T3-L1 fibroblasts into adipocytes, is not involved in the stimulation of glucose uptake.
datePublished:2006-12-22T00:00:00Z
dateModified:2006-12-22T00:00:00Z
pageStart:219
pageEnd:229
sameAs:https://doi.org/10.1007/s00018-006-6445-4
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Differentiation
endocannabinoid system
energy homeostasis
glucose transport
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signal transduction
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Biochemistry
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headline:Endocannabinoids in adipocytes during differentiation and their role in glucose uptake
description:The molecular basis for the control of energy balance by the endocannabinoid anandamide (AEA) is still unclear. Here, we show that murine 3T3-L1 fibroblasts have the machinery to bind, synthesize and degrade AEA, and that their differentiation into adipocytes increases by approximately twofold the binding efficiency of cannabinoid receptors (CBR), and by approximately twofold and approximately threefold, respectively, the catalytic efficiency of the AEA transporter and AEA hydrolase. In contrast, the activity of the AEA synthetase and the binding efficiency of vanilloid receptor were not affected by the differentiation process. In addition, we demonstrate that AEA increases by approximately twofold insulin-stimulated glucose uptake in differentiated adipocytes, according to a CB1R-dependent mechanism that involves nitric oxide synthase, but not lipoxygenase or cyclooxygenase. We also show that AEA binding to peroxisome proliferator-activated receptor-γ, known to induce differentiation of 3T3-L1 fibroblasts into adipocytes, is not involved in the stimulation of glucose uptake.
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endocannabinoid system
energy homeostasis
glucose transport
receptor
signal transduction
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Biochemistry
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