LINK . SPRINGER . COM {}

Matching Content Categories {📚}

• Science
• Mobile Technology & AI
• Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 8,280,528 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

article, mrna, vaccination, vaccines, access, privacy, cookies, content, data, information, publish, research, search, injection, carralot, probst, pascolo, strategy, rna, log, journal, life, cmls, immunity, naked, hoerr, scheel, genetic, open, discover, author, tübingen, germany, cell, springer, optional, personal, parties, policy, find, track, cellular, molecular, sciences, polarization, induced, direct, sequencestabilized, cite, teufel,

Topics {✒️}

th1-type immune response globin utr-stabilized mrna month download article/chapter long-term uncontrolled expression anti-dna antibodies mrna vaccines stabilized mrna coding related subjects genetic vaccination privacy choices/manage cookies dna vaccination full article pdf vaccination strategy primes versatile vaccination strategy european economic area scope submit manuscript check access author correspondence instant access conditions privacy policy accepting optional cookies article cellular main content log vaccination strategy journal finder publish cell biology th2 article log life sci mrna vaccine article cite mrna injection article carralot privacy policy personal data β-galactosidase books a cell information optional cookies manage preferences essential cookies cookies skip subscription content similar content data protection data demonstrate pascolo institute institution subscribe journal publish

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines
         description:In the context of developing a safe genetic vaccination strategy we tested and studied globin-stabilized mRNA-based vaccination in mice. This vaccination strategy has the advantages of genetic vaccination (easy production, adaptability to any disease and inexpensive storage when lyophilized), but not the drawbacks of DNA vaccination (long-term uncontrolled expression of a transgene, possibility of integration into the host genome and possible induction of anti-DNA antibodies). We report here that injection of naked β-globin untranslated region (UTR)-stabilized mRNA coding for β-galactosidase is followed by detectable translation in vivo. In addition, we show that such a vaccination strategy primes a T helper 2 (Th2) type of response which can be enhanced and shifted to a Th1-type immune response by application of recombinant granulocyte/macrophage colony-stimulating factor 1 day after mRNA injection. Our data demonstrate that the administration of globin UTR-stabilized mRNA is a versatile vaccination strategy that can be manipulated to fit the requirement of antiviral, antibacterial or antitumor immunity.
         datePublished:
         dateModified:
         pageStart:2418
         pageEnd:2424
         sameAs:https://doi.org/10.1007/s00018-004-4255-0
         keywords:
            Vaccination
            Th1/Th2 cell
            rodent
            gene therapy
            messenger RNA
            GM-CSF
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
         isPartOf:
            name:Cellular and Molecular Life Sciences CMLS
            issn:
               1420-9071
               1420-682X
            volumeNumber:61
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Birkhäuser-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:J.-P. Carralot
               affiliation:
                     name:CureVac GmbH
                     address:
                        name:CureVac GmbH, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
                     name:Department of Immunology
                     address:
                        name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:J. Probst
               affiliation:
                     name:CureVac GmbH
                     address:
                        name:CureVac GmbH, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
                     name:Department of Immunology
                     address:
                        name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:I. Hoerr
               affiliation:
                     name:CureVac GmbH
                     address:
                        name:CureVac GmbH, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:B. Scheel
               affiliation:
                     name:CureVac GmbH
                     address:
                        name:CureVac GmbH, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
                     name:Department of Immunology
                     address:
                        name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:R. Teufel
               affiliation:
                     name:CureVac GmbH
                     address:
                        name:CureVac GmbH, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:G. Jung
               affiliation:
                     name:Institute of Organic Chemistry
                     address:
                        name:Institute of Organic Chemistry, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:H.-G. Rammensee
               affiliation:
                     name:Department of Immunology
                     address:
                        name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:S. Pascolo
               affiliation:
                     name:CureVac GmbH
                     address:
                        name:CureVac GmbH, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
                     name:Department of Immunology
                     address:
                        name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines
      description:In the context of developing a safe genetic vaccination strategy we tested and studied globin-stabilized mRNA-based vaccination in mice. This vaccination strategy has the advantages of genetic vaccination (easy production, adaptability to any disease and inexpensive storage when lyophilized), but not the drawbacks of DNA vaccination (long-term uncontrolled expression of a transgene, possibility of integration into the host genome and possible induction of anti-DNA antibodies). We report here that injection of naked β-globin untranslated region (UTR)-stabilized mRNA coding for β-galactosidase is followed by detectable translation in vivo. In addition, we show that such a vaccination strategy primes a T helper 2 (Th2) type of response which can be enhanced and shifted to a Th1-type immune response by application of recombinant granulocyte/macrophage colony-stimulating factor 1 day after mRNA injection. Our data demonstrate that the administration of globin UTR-stabilized mRNA is a versatile vaccination strategy that can be manipulated to fit the requirement of antiviral, antibacterial or antitumor immunity.
      datePublished:
      dateModified:
      pageStart:2418
      pageEnd:2424
      sameAs:https://doi.org/10.1007/s00018-004-4255-0
      keywords:
         Vaccination
         Th1/Th2 cell
         rodent
         gene therapy
         messenger RNA
         GM-CSF
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
      image:
      isPartOf:
         name:Cellular and Molecular Life Sciences CMLS
         issn:
            1420-9071
            1420-682X
         volumeNumber:61
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Birkhäuser-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:J.-P. Carralot
            affiliation:
                  name:CureVac GmbH
                  address:
                     name:CureVac GmbH, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
                  name:Department of Immunology
                  address:
                     name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. Probst
            affiliation:
                  name:CureVac GmbH
                  address:
                     name:CureVac GmbH, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
                  name:Department of Immunology
                  address:
                     name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:I. Hoerr
            affiliation:
                  name:CureVac GmbH
                  address:
                     name:CureVac GmbH, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:B. Scheel
            affiliation:
                  name:CureVac GmbH
                  address:
                     name:CureVac GmbH, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
                  name:Department of Immunology
                  address:
                     name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:R. Teufel
            affiliation:
                  name:CureVac GmbH
                  address:
                     name:CureVac GmbH, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:G. Jung
            affiliation:
                  name:Institute of Organic Chemistry
                  address:
                     name:Institute of Organic Chemistry, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:H.-G. Rammensee
            affiliation:
                  name:Department of Immunology
                  address:
                     name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. Pascolo
            affiliation:
                  name:CureVac GmbH
                  address:
                     name:CureVac GmbH, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
                  name:Department of Immunology
                  address:
                     name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Life Sciences CMLS
      issn:
         1420-9071
         1420-682X
      volumeNumber:61
Organization:
      name:Birkhäuser-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:CureVac GmbH
      address:
         name:CureVac GmbH, Tübingen, Germany
         type:PostalAddress
      name:Department of Immunology
      address:
         name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
         type:PostalAddress
      name:CureVac GmbH
      address:
         name:CureVac GmbH, Tübingen, Germany
         type:PostalAddress
      name:Department of Immunology
      address:
         name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
         type:PostalAddress
      name:CureVac GmbH
      address:
         name:CureVac GmbH, Tübingen, Germany
         type:PostalAddress
      name:CureVac GmbH
      address:
         name:CureVac GmbH, Tübingen, Germany
         type:PostalAddress
      name:Department of Immunology
      address:
         name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
         type:PostalAddress
      name:CureVac GmbH
      address:
         name:CureVac GmbH, Tübingen, Germany
         type:PostalAddress
      name:Institute of Organic Chemistry
      address:
         name:Institute of Organic Chemistry, Tübingen, Germany
         type:PostalAddress
      name:Department of Immunology
      address:
         name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
         type:PostalAddress
      name:CureVac GmbH
      address:
         name:CureVac GmbH, Tübingen, Germany
         type:PostalAddress
      name:Department of Immunology
      address:
         name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:J.-P. Carralot
      affiliation:
            name:CureVac GmbH
            address:
               name:CureVac GmbH, Tübingen, Germany
               type:PostalAddress
            type:Organization
            name:Department of Immunology
            address:
               name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:J. Probst
      affiliation:
            name:CureVac GmbH
            address:
               name:CureVac GmbH, Tübingen, Germany
               type:PostalAddress
            type:Organization
            name:Department of Immunology
            address:
               name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:I. Hoerr
      affiliation:
            name:CureVac GmbH
            address:
               name:CureVac GmbH, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:B. Scheel
      affiliation:
            name:CureVac GmbH
            address:
               name:CureVac GmbH, Tübingen, Germany
               type:PostalAddress
            type:Organization
            name:Department of Immunology
            address:
               name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:R. Teufel
      affiliation:
            name:CureVac GmbH
            address:
               name:CureVac GmbH, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:G. Jung
      affiliation:
            name:Institute of Organic Chemistry
            address:
               name:Institute of Organic Chemistry, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:H.-G. Rammensee
      affiliation:
            name:Department of Immunology
            address:
               name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
               type:PostalAddress
            type:Organization
      name:S. Pascolo
      affiliation:
            name:CureVac GmbH
            address:
               name:CureVac GmbH, Tübingen, Germany
               type:PostalAddress
            type:Organization
            name:Department of Immunology
            address:
               name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:CureVac GmbH, Tübingen, Germany
      name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
      name:CureVac GmbH, Tübingen, Germany
      name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
      name:CureVac GmbH, Tübingen, Germany
      name:CureVac GmbH, Tübingen, Germany
      name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
      name:CureVac GmbH, Tübingen, Germany
      name:Institute of Organic Chemistry, Tübingen, Germany
      name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
      name:CureVac GmbH, Tübingen, Germany
      name:Institute for Cell Biology, Department of Immunology, Tübingen, Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(39)

• Earnings of https://www.springernature.com/gp/authors
• What's the monthly income of https://link.springernature.com/home/?
• Find out how much https://order.springer.com/public/cart earns monthly
• https://www.editorialmanager.com/life/default2.aspx's financial summary
• Explore the financials of https://www.springernature.com/gp/librarians/licensing/agc/journals
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J.-P.%20Carralot's financial summary
• How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22J.-P.%20Carralot%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J.%20Probst's financial summary
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22J.%20Probst%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=I.%20Hoerr generate?
• How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22I.%20Hoerr%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=B.%20Scheel pull in monthly?
• What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22B.%20Scheel%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What is the monthly revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=R.%20Teufel?
• What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22R.%20Teufel%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=G.%20Jung?
• How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22G.%20Jung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
• What's the income generated by https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=H.-G.%20Rammensee each month?
• What's the income generated by https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22H.-G.%20Rammensee%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en each month?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=S.%20Pascolo pull in?
• What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22S.%20Pascolo%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
• How much cash flow does https://s100.copyright.com/AppDispatchServlet?title=Polarization%20of%20immunity%20induced%20by%20direct%20injection%20of%20naked%20sequence-stabilized%20mRNA%20vaccines&author=J.-P.%20Carralot%20et%20al&contentID=10.1007%2Fs00018-004-4255-0©right=Birkh%C3%A4user-Verlag%20Basel&publication=1420-682X&publicationDate=2004-09&publisherName=SpringerNature&orderBeanReset=true have monthly?
• How much does https://citation-needed.springer.com/v2/references/10.1007/s00018-004-4255-0?format=refman&flavour=citation pull in?
• What is the monthly revenue of https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral?
• Discover the revenue of https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research
• https://www.springernature.com/gp/products's total income per month
• What's https://www.springernature.com/gp/librarians's gross income?
• https://www.springernature.com/gp/societies's total income per month
• What is the earnings of https://www.springernature.com/gp/partners?
• See how much https://www.springer.com/ makes per month
• How much money does https://www.nature.com/ make?
• Learn about the earnings of https://www.biomedcentral.com/
• https://www.palgrave.com/'s revenue stream
• What are the earnings of https://www.apress.com/?
• How much does https://www.springernature.com/gp/legal/ccpa rake in every month?
• Profit of https://www.springernature.com/gp/info/accessibility
• What's the total monthly financial gain of https://support.springernature.com/en/support/home?
• What's the financial gain of https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations?
• How much does https://www.springernature.com/ earn?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Clipboard.js
• Prism.js

CDN Services {📦}

• Crossref