We are analyzing https://link.springer.com/article/10.1007/s00018-004-4201-1.

Title:
Biochemistry and biology of mammalian DNA methyltransferases | Cellular and Molecular Life Sciences
Description:
DNA methylation is a stable but not irreversible epigenetic signal that silences gene expression. It has a variety of important functions in mammals, including control of gene expression, cellular differentiation and development, preservation of chromosomal integrity, parental imprinting and X-chromosome inactivation. In addition, it has been implicated in brain function and the development of the immune system. Somatic alterations in genomic methylation patterns contribute to the etiology of human cancers and ageing. It is tightly interwoven with the modification of histone tails and other epigenetic signals. Here we review our current understanding of the molecular enzymology of the mammalian DNA methyltransferases Dnmt1, Dnmt3a, Dnmt3b and Dnmt2 and the roles of the enzymes in the above-mentioned biological processes.
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Keywords {🔍}

dna, article, methylation, privacy, cookies, content, jeltsch, access, function, information, publish, search, methyltransferases, data, log, journal, research, cellular, molecular, life, cmls, mammalian, hermann, gowher, gene, expression, dnmt, regulation, chapter, discover, author, springer, optional, analysis, personal, including, parties, policy, find, track, sciences, biochemistry, biology, review, cite, explore, epigenetic, development, dnmta, dnmtb,

Topics {✒️}

month download article/chapter dna methylation mammalian dna methyltransferases privacy choices/manage cookies dna methyltransferases usage analysis full article pdf gene expression access european economic area scope submit manuscript x-chromosome inactivation mentioned biological processes justus-liebig-universität conditions privacy policy author correspondence irreversible epigenetic signal heinrich-buff-ring 58 silences gene expression accepting optional cookies related subjects international university bremen modification enzymes journal finder publish article cellular molecular enzymology life sci check access instant access article log privacy policy personal data books a gene expression brain function optional cookies manage preferences including control cellular differentiation dnmt3a dnmt3b article cite article hermann subscription content similar content information data protection essential cookies cookies skip epigenetic signals

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         description:DNA methylation is a stable but not irreversible epigenetic signal that silences gene expression. It has a variety of important functions in mammals, including control of gene expression, cellular differentiation and development, preservation of chromosomal integrity, parental imprinting and X-chromosome inactivation. In addition, it has been implicated in brain function and the development of the immune system. Somatic alterations in genomic methylation patterns contribute to the etiology of human cancers and ageing. It is tightly interwoven with the modification of histone tails and other epigenetic signals. Here we review our current understanding of the molecular enzymology of the mammalian DNA methyltransferases Dnmt1, Dnmt3a, Dnmt3b and Dnmt2 and the roles of the enzymes in the above-mentioned biological processes.
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