We are analyzing https://link.springer.com/article/10.1007/s00018-004-4114-z.

Title:
Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic | Cellular and Molecular Life Sciences
Description:
Selenium (Se), once known only for its potential toxicity, is now well established as an essential trace element for mammals. Insufficient Se intake predisposes to and manifests in a variety of diseases. Recent studies have proven that it is the synthesis of selenocysteine (Sec)-containing proteins, designated selenoproteins, which represents an essential prerequisite for regular development and a long and healthy life. New transgenic mouse models analysing those selenoproteins with proven enzymatic functions displayed particular phenotypes and highlighted essential Se-dependent processes in development, growth or against specific challenges. While there is a growing molecular understanding of and general agreement on the importance of sufficiently high Se intake and undisturbed selenoprotein biosynthesis, many of the recently identified selenoproteins are still uncharacterised, and the effects and consequences of supra-physiological Se dosages are not biochemically understood. With the recent definition of the human and mouse selenoproteomes and a growing number of available tools, the Se field is now geared for a great leap forward. Se biology has already broadened our knowledge about the genetic code and about protein translation. It now holds great promises also for a better understanding of some key aspects of cancer, inflammation, fertility and prevention of age-associated diseases.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Technology & Computing
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

article, selenoproteins, essential, privacy, cookies, content, selenium, schomburg, mouse, information, publish, search, life, mammals, schweizer, access, chapter, author, berlin, data, log, journal, research, molecular, cmls, köhrle, development, models, discover, springer, optional, personal, including, parties, policy, find, track, cellular, sciences, extraordinary, enigmatic, cite, explore, trace, element, intake, diseases, recent, proven, selenocysteine,

Topics {✒️}

month download article/chapter essential trace element supra-physiological se dosages genetic code related subjects privacy choices/manage cookies mouse models recently identified selenoproteins full article pdf growing molecular understanding european economic area scope submit manuscript undisturbed selenoprotein biosynthesis great leap forward holds great promises conditions privacy policy protein translation accepting optional cookies mouse selenoproteomes main content log author correspondence journal finder publish article cellular proteins check access health selenium instant access designated selenoproteins healthy life life sci privacy policy personal data selenocysteine sec books a se field se biology article schomburg article log optional cookies manage preferences essential cookies data protection article cite cookies skip subscription content similar content growing number institution subscribe

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic
         description:Selenium (Se), once known only for its potential toxicity, is now well established as an essential trace element for mammals. Insufficient Se intake predisposes to and manifests in a variety of diseases. Recent studies have proven that it is the synthesis of selenocysteine (Sec)-containing proteins, designated selenoproteins, which represents an essential prerequisite for regular development and a long and healthy life. New transgenic mouse models analysing those selenoproteins with proven enzymatic functions displayed particular phenotypes and highlighted essential Se-dependent processes in development, growth or against specific challenges. While there is a growing molecular understanding of and general agreement on the importance of sufficiently high Se intake and undisturbed selenoprotein biosynthesis, many of the recently identified selenoproteins are still uncharacterised, and the effects and consequences of supra-physiological Se dosages are not biochemically understood. With the recent definition of the human and mouse selenoproteomes and a growing number of available tools, the Se field is now geared for a great leap forward. Se biology has already broadened our knowledge about the genetic code and about protein translation. It now holds great promises also for a better understanding of some key aspects of cancer, inflammation, fertility and prevention of age-associated diseases.
         datePublished:
         dateModified:
         pageStart:1988
         pageEnd:1995
         sameAs:https://doi.org/10.1007/s00018-004-4114-z
         keywords:
            Selenium
            selenoproteins
            trace element
            mouse model
            translation
            health
            genetic code
            Cell Biology
            Biomedicine
            general
            Life Sciences
            Biochemistry
         image:
         isPartOf:
            name:Cellular and Molecular Life Sciences CMLS
            issn:
               1420-9071
               1420-682X
            volumeNumber:61
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Birkhäuser-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:L. Schomburg
               affiliation:
                     name:Charité – Universitätsmedizin Berlin
                     address:
                        name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:U. Schweizer
               affiliation:
                     name:Charité – Universitätsmedizin Berlin
                     address:
                        name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
                        type:PostalAddress
                     type:Organization
                     name:Charité – Universitätsmedizin Berlin
                     address:
                        name:Neurobiologie des Selens, Neurowissenschaftliches Forschungszentrum, Charité – Universitätsmedizin Berlin, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:J. Köhrle
               affiliation:
                     name:Charité – Universitätsmedizin Berlin
                     address:
                        name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic
      description:Selenium (Se), once known only for its potential toxicity, is now well established as an essential trace element for mammals. Insufficient Se intake predisposes to and manifests in a variety of diseases. Recent studies have proven that it is the synthesis of selenocysteine (Sec)-containing proteins, designated selenoproteins, which represents an essential prerequisite for regular development and a long and healthy life. New transgenic mouse models analysing those selenoproteins with proven enzymatic functions displayed particular phenotypes and highlighted essential Se-dependent processes in development, growth or against specific challenges. While there is a growing molecular understanding of and general agreement on the importance of sufficiently high Se intake and undisturbed selenoprotein biosynthesis, many of the recently identified selenoproteins are still uncharacterised, and the effects and consequences of supra-physiological Se dosages are not biochemically understood. With the recent definition of the human and mouse selenoproteomes and a growing number of available tools, the Se field is now geared for a great leap forward. Se biology has already broadened our knowledge about the genetic code and about protein translation. It now holds great promises also for a better understanding of some key aspects of cancer, inflammation, fertility and prevention of age-associated diseases.
      datePublished:
      dateModified:
      pageStart:1988
      pageEnd:1995
      sameAs:https://doi.org/10.1007/s00018-004-4114-z
      keywords:
         Selenium
         selenoproteins
         trace element
         mouse model
         translation
         health
         genetic code
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
      image:
      isPartOf:
         name:Cellular and Molecular Life Sciences CMLS
         issn:
            1420-9071
            1420-682X
         volumeNumber:61
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Birkhäuser-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:L. Schomburg
            affiliation:
                  name:Charité – Universitätsmedizin Berlin
                  address:
                     name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:U. Schweizer
            affiliation:
                  name:Charité – Universitätsmedizin Berlin
                  address:
                     name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
                     type:PostalAddress
                  type:Organization
                  name:Charité – Universitätsmedizin Berlin
                  address:
                     name:Neurobiologie des Selens, Neurowissenschaftliches Forschungszentrum, Charité – Universitätsmedizin Berlin, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. Köhrle
            affiliation:
                  name:Charité – Universitätsmedizin Berlin
                  address:
                     name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cellular and Molecular Life Sciences CMLS
      issn:
         1420-9071
         1420-682X
      volumeNumber:61
Organization:
      name:Birkhäuser-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Charité – Universitätsmedizin Berlin
      address:
         name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
         type:PostalAddress
      name:Charité – Universitätsmedizin Berlin
      address:
         name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
         type:PostalAddress
      name:Charité – Universitätsmedizin Berlin
      address:
         name:Neurobiologie des Selens, Neurowissenschaftliches Forschungszentrum, Charité – Universitätsmedizin Berlin, Berlin, Germany
         type:PostalAddress
      name:Charité – Universitätsmedizin Berlin
      address:
         name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:L. Schomburg
      affiliation:
            name:Charité – Universitätsmedizin Berlin
            address:
               name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:U. Schweizer
      affiliation:
            name:Charité – Universitätsmedizin Berlin
            address:
               name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
               type:PostalAddress
            type:Organization
            name:Charité – Universitätsmedizin Berlin
            address:
               name:Neurobiologie des Selens, Neurowissenschaftliches Forschungszentrum, Charité – Universitätsmedizin Berlin, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:J. Köhrle
      affiliation:
            name:Charité – Universitätsmedizin Berlin
            address:
               name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
      name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
      name:Neurobiologie des Selens, Neurowissenschaftliches Forschungszentrum, Charité – Universitätsmedizin Berlin, Berlin, Germany
      name:Institut für Experimentelle Endokrinologie, Charité – Universitätsmedizin Berlin, Berlin, Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(29)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.31s.

LINK . SPRINGER . COM {}