We are analyzing https://link.springer.com/article/10.1007/s00011-024-01870-z.

Title:
γδ T cells in oral diseases | Inflammation Research
Description:
Objective γδ T cells are a distinct subset of unconventional T cells, which link innate and adaptive immunity by secreting cytokines and interacting with other immune cells, thereby modulating immune responses. As the first line of host defense, γδ T cells are essential for mucosal homeostasis and immune surveillance. When abnormally activated or impaired, γδ T cells can contribute to pathogenic processes. Accumulating evidence has revealed substantial impacts of γδ T cells on the pathogenesis of cancers, infections, and immune-inflammatory diseases. γδ T cells exhibit dual roles in cancers, promoting or inhibiting tumor growth, depending on their phenotypes and the clinical stage of cancers. During infections, γδ T cells exert high cytotoxic activity in infectious diseases, which is essential for combating bacterial and viral infections by recognizing foreign antigens and activating other immune cells. γδ T cells are also implicated in the onset and progression of immune-inflammatory diseases. However, the specific involvement and underlying mechanisms of γδ T cells in oral diseases have not been systematically discussed. Methods We conducted a systematic literature review using the PubMed/MEDLINE databases to identify and analyze relevant literature on the roles of γδ T cells in oral diseases. Results The literature review revealed that γδ T cells play a pivotal role in maintaining oral mucosal homeostasis and are involved in the pathogenesis of oral cancers, periodontal diseases, graft-versus-host disease (GVHD), oral lichen planus (OLP), and oral candidiasis. γδ T cells mainly influence various pathophysiological processes, such as anti-tumor activity, eradication of infection, and immune response regulation. Conclusion This review focuses on the involvement of γδ T cells in oral diseases, with a particular emphasis on the main functions and underlying mechanisms by which γδ T cells influence the pathogenesis and progression of these conditions. This review underscores the potential of γδ T cells as therapeutic targets in managing oral health issues.
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Topics {✒️}

chronic graft-versus-host disease graft-versus-host disease biology xenogeneic graft-versus-host disease graft-versus-host disease antibody-dependent anti-cytomegalovirus activity month download article/chapter pubmed google scholar candida albicans-mediated infection ya-qin tan writing—original draft preparation tumor-infiltrating il-17-producing gammadelta major histocompatibility barrier oral lichen planus cd1-mediated gamma/delta lethal murine graft myeloid-derived suppressor cells immune-mediated inflammatory diseases oral disease profiles professional antigen-presentation function dermal il-17-producing γδ pubmed/medline databases full article pdf oral pathol med donor gamma/delta expressing γδt17 cells promote il-17-producing γδt cells cell cytokine production epithelial barrier tissues mucosal host defense graft-facilitating doses oral epithelial cells cell host microbe il-17 receptor signaling recognizing foreign antigens privacy choices/manage cookies oral biomedicine ministry article wei anti-tumor effector functions related subjects periodontal disease allogeneic hematopoietic transplantation clin exp pathol host disease contemplating dichotomous nature anti-tumor activity host immune cells antigen presentation capacity oral tumor cells allogenic donor marrow interleukin-23-dependent mechanism

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Gamma-delta (γδ) T cells: friend or foe in cancer development?

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