We are analyzing https://link.springer.com/article/10.1007/pl00006672.

Title:
B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion | Cancer Immunology, Immunotherapy
Description:
Accumulating data are showing that the humoral immune response against tumors could favor tumor progression. However, no B lymphocyte pathology has been reported in cancer. Using anti-IgM Ab we nonspecifically depleted B cells in tumor-bearing mice, a treatment that resulted in significant reduction of tumor burden. We analyzed the B lymphocyte phenotype of abdominal lymph nodes and peripheral blood from advanced colon cancer patients by flow cytometry, and compared the B cell phenotype with that found in samples from normal donors. In both lymph nodes and peripheral blood of cancer patients, abnormal populations of B lymphocytes appeared that express an increased CD21 and/or sTn antigens on their cell surface. All patients showed a reduction of CD19+ cells. In a limited clinical test, we analyzed the effects of a partial B cell depletion with Rituximab. The treated patients did not develop any side-effects; the CD21-hyperpositive lymphocytes were reduced, but the proportion of sTn-positive lymphocytes remained unaffected. Apparent reduction of the tumor burden was reported in 50% of the patients when the treatment was ended.
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Keywords {🔍}

cancer, article, cell, patients, access, privacy, cookies, content, data, information, publish, search, lymphocyte, colorectal, depletion, lymphocytes, lymphoma, log, journal, research, pathology, clinical, effects, partial, barberaguillem, nelson, barr, tumor, cells, reduction, open, discover, springer, optional, personal, parties, policy, find, track, immunology, immunotherapy, human, experimental, therapeutic, cite, emilio, bud, barbara, julie, nyhus,

Topics {✒️}

cell lymphoma patients month download article/chapter human colorectal cancer article cancer immunology cell lymphoma rituximab-treated diffuse large emilio barbera-guillem article barbera-guillem related subjects humoral immune response privacy choices/manage cookies colorectal cancer full article pdf cd19+ cells refractory/relapsed large cd21-hyperpositive lymphocytes european economic area anti-igm ab limited clinical test lan feng & james conditions privacy policy favor tumor progression tumor-bearing mice clinical therapeutic effects accepting optional cookies cell depletion abdominal lymph nodes check access instant access cancer patients journal finder publish cell phenotype cell surface cell responses article log immunotherapy article personal data cells privacy policy article cite stn antigens books a increased cd21 treated patients information cancer optional cookies data protection manage preferences lymph nodes

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         headline:B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion
         description: Accumulating data are showing that the humoral immune response against tumors could favor tumor progression. However, no B lymphocyte pathology has been reported in cancer. Using anti-IgM Ab we nonspecifically depleted B cells in tumor-bearing mice, a treatment that resulted in significant reduction of tumor burden. We analyzed the B lymphocyte phenotype of abdominal lymph nodes and peripheral blood from advanced colon cancer patients by flow cytometry, and compared the B cell phenotype with that found in samples from normal donors. In both lymph nodes and peripheral blood of cancer patients, abnormal populations of B lymphocytes appeared that express an increased CD21 and/or sTn antigens on their cell surface. All patients showed a reduction of CD19+ cells. In a limited clinical test, we analyzed the effects of a partial B cell depletion with Rituximab. The treated patients did not develop any side-effects; the CD21-hyperpositive lymphocytes were reduced, but the proportion of sTn-positive lymphocytes remained unaffected. Apparent reduction of the tumor burden was reported in 50% of the patients when the treatment was ended.
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      headline:B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion
      description: Accumulating data are showing that the humoral immune response against tumors could favor tumor progression. However, no B lymphocyte pathology has been reported in cancer. Using anti-IgM Ab we nonspecifically depleted B cells in tumor-bearing mice, a treatment that resulted in significant reduction of tumor burden. We analyzed the B lymphocyte phenotype of abdominal lymph nodes and peripheral blood from advanced colon cancer patients by flow cytometry, and compared the B cell phenotype with that found in samples from normal donors. In both lymph nodes and peripheral blood of cancer patients, abnormal populations of B lymphocytes appeared that express an increased CD21 and/or sTn antigens on their cell surface. All patients showed a reduction of CD19+ cells. In a limited clinical test, we analyzed the effects of a partial B cell depletion with Rituximab. The treated patients did not develop any side-effects; the CD21-hyperpositive lymphocytes were reduced, but the proportion of sTn-positive lymphocytes remained unaffected. Apparent reduction of the tumor burden was reported in 50% of the patients when the treatment was ended.
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         CD21 hyperexpression
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         Cancer Research
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