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Title:
Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation | Virchows Archiv B Cell Pathology
Description:
It is generally accepted that the lysosomal compartment plays an important role in the degradation of cellular components.In this communication we discuss various experimental models which have been used to study mechanisms of intralysosomal degradation and also discuss the evidence obtained in support of the following proposals: 1. The autophagosomes can be isolated into high purity and are the subcellular locus of induced protein degradation. 2. Different membrane components such as proteins and lipids are degraded at different rates inside the lysosomes. Intralysosomal hydrolysis is not the rate limiting step in degradation. 3. Lysosomes take up soluble material in vitro by invagination and pinching off of their membranes (microautophagy). 4. Secretory vesicles can degrade their secretory contents by fusing with the lysosomes.
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month download article/chapter de schepper pj article virchows archiv intravenously injected mitochondria full article pdf privacy choices/manage cookies wattiaux-de coninck cellular autophagy induced induced cellular autophagy european economic area rate limiting step elsevier/north holland anterior pituitary gland conditions privacy policy rat pancreatic islets mouse peritoneal macrophages roneveaux-dupal mf vivo labelled lysosomes article autophagy article marzella rat liver induced perfused rat liver rat liver perfusion phenobarbital-induced membranes endoplasmic reticulum membranes accepting optional cookies lysosomal compartment plays lysosomal triacylglycerol lipase huddinge university hospital vinblastine-induced autophagocytosis rat liver lysosomes main content log induced protein degradation intracellular degradation published macrophage protein turnover related subjects journal finder publish kupffer cell lysosomes isolated rat hepatocytes pancreatic insulin content general injurious effects check access instant access virchows archiv article log intracellular protein degradation article cite de duve weibel er virchows arch
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description:It is generally accepted that the lysosomal compartment plays an important role in the degradation of cellular components. In this communication we discuss various experimental models which have been used to study mechanisms of intralysosomal degradation and also discuss the evidence obtained in support of the following proposals:
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Lysosomes
Autophagosomes
Isolation
Proteolysis
Microautophagy
Crinophagy
Pathology
Cell Biology
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headline:Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation
description:It is generally accepted that the lysosomal compartment plays an important role in the degradation of cellular components. In this communication we discuss various experimental models which have been used to study mechanisms of intralysosomal degradation and also discuss the evidence obtained in support of the following proposals:
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Isolation
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Microautophagy
Crinophagy
Pathology
Cell Biology
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