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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
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We are analyzing https://link.springer.com/article/10.1007/bf02900689.

Title:
Prophylaxis of tumor through oral administration of IL-12 GM-CSF gene carried by live attenuated salmonella | Science Bulletin
Description:
A live attenuated AraA- autotrophic mutant ofSalmonella typhimurium (SL3261) was used as carrier for eukaryotic expression vectors EGFPN1, pCMVmIL-12, pCMVhIL-12, pCMVmGM-CSF and pCMVhGM-CSF and was administered orally to BALB/c and C57BL/6 mice. After 6 weeks, these mice were challenged with 4T1 and Lewis tumor cells respectively. GFP expression and gene integration could be detected in miceโ€™s livers, spleens, intestines, kidneys and tumors. The serum level of cytokines increased significantly in treated mice, so did the ratio of CD 8 + /CD 4 + , which resulted in the tumor regression and prolongation of the survival time of those mice. These researches laid an experimental foundation for the tumor gene therapy using live attenuated salmonella.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {๐Ÿ“š}

  • Science
  • Education
  • Telecommunications

Content Management System {๐Ÿ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {๐Ÿ“ˆ}

What is the average monthly size of link.springer.com audience?

๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {๐Ÿ’ธ}

We find it hard to spot revenue streams.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {๐Ÿ”}

article, gene, google, scholar, cas, pubmed, oral, attenuated, salmonella, therapy, tumor, privacy, cookies, content, live, typhimurium, mice, access, publish, research, search, science, administration, yuhua, kunyuan, xie, cancer, immunity, data, information, log, journal, gmcsf, hui, guo, cells, interleukin, discover, blood, induction, nature, granulocytemacrophage, colony, stimulating, factor, download, author, china, springer, optional,

Topics {โœ’๏ธ}

month download article/chapter cancer gene therapy live attenuated salmonella tumor gene therapy achieves long-term survival vaccine-induced tumor immunity state key laboratory full article pdf privacy choices/manage cookies google scholar oral dna vaccination related subjects article yuhua european economic area cytokines increased significantly direct intratumoral injection enhanced adjuvant effect oral administration conditions privacy policy gene integration gene transfer mouse langerhans cells lewis tumor cells military medical university accepting optional cookies main content log salmonella typhimurium medina check access instant access journal finder publish gm-csf author correspondence article log oral vaccine nature biotech life science article cite interleukin-12 compared guo kunyuan privacy policy personal data books a attenuatedsalmonella typhimurium pcmvmgm-csf pcmvhgm-csf optional cookies manage preferences wang feng gfp expression

Schema {๐Ÿ—บ๏ธ}

WebPage:
      mainEntity:
         headline:Prophylaxis of tumor through oral administration of IL-12 GM-CSF gene carried by live attenuated salmonella
         description:A live attenuated AraA- autotrophic mutant ofSalmonella typhimurium (SL3261) was used as carrier for eukaryotic expression vectors EGFPN1, pCMVmIL-12, pCMVhIL-12, pCMVmGM-CSF and pCMVhGM-CSF and was administered orally to BALB/c and C57BL/6 mice. After 6 weeks, these mice were challenged with 4T1 and Lewis tumor cells respectively. GFP expression and gene integration could be detected in miceโ€™s livers, spleens, intestines, kidneys and tumors. The serum level of cytokines increased significantly in treated mice, so did the ratio of CD 8 + /CD 4 + , which resulted in the tumor regression and prolongation of the survival time of those mice. These researches laid an experimental foundation for the tumor gene therapy using live attenuated salmonella.
         datePublished:
         dateModified:
         pageStart:1107
         pageEnd:1111
         sameAs:https://doi.org/10.1007/BF02900689
         keywords:
            oral administration
            gene therapy
            attenuated salmonella
            Science
            Humanities and Social Sciences
            multidisciplinary
            Life Sciences
            general
            Physics
            Chemistry/Food Science
            Earth Sciences
            Engineering
         image:
         isPartOf:
            name:Chinese Science Bulletin
            issn:
               1861-9541
               1001-6538
            volumeNumber:46
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Science in China Press
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Li Yuhua
               affiliation:
                     name:First Military Medical University
                     address:
                        name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:Fudan University
                     address:
                        name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chen Hui
               affiliation:
                     name:Fudan University
                     address:
                        name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                        type:PostalAddress
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               name:Guo Kunyuan
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                     name:First Military Medical University
                     address:
                        name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Xie Yongmei
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                     name:Fudan University
                     address:
                        name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wang Feng
               affiliation:
                     name:Central Research Lab of First Hospital of Shanghai
                     address:
                        name:Central Research Lab of First Hospital of Shanghai, Shangshai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xie Kuangcheng
               affiliation:
                     name:Fudan University
                     address:
                        name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Huang Jiangsheng
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                     name:Fudan University
                     address:
                        name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ren Daming
               affiliation:
                     name:Fudan University
                     address:
                        name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
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ScholarlyArticle:
      headline:Prophylaxis of tumor through oral administration of IL-12 GM-CSF gene carried by live attenuated salmonella
      description:A live attenuated AraA- autotrophic mutant ofSalmonella typhimurium (SL3261) was used as carrier for eukaryotic expression vectors EGFPN1, pCMVmIL-12, pCMVhIL-12, pCMVmGM-CSF and pCMVhGM-CSF and was administered orally to BALB/c and C57BL/6 mice. After 6 weeks, these mice were challenged with 4T1 and Lewis tumor cells respectively. GFP expression and gene integration could be detected in miceโ€™s livers, spleens, intestines, kidneys and tumors. The serum level of cytokines increased significantly in treated mice, so did the ratio of CD 8 + /CD 4 + , which resulted in the tumor regression and prolongation of the survival time of those mice. These researches laid an experimental foundation for the tumor gene therapy using live attenuated salmonella.
      datePublished:
      dateModified:
      pageStart:1107
      pageEnd:1111
      sameAs:https://doi.org/10.1007/BF02900689
      keywords:
         oral administration
         gene therapy
         attenuated salmonella
         Science
         Humanities and Social Sciences
         multidisciplinary
         Life Sciences
         general
         Physics
         Chemistry/Food Science
         Earth Sciences
         Engineering
      image:
      isPartOf:
         name:Chinese Science Bulletin
         issn:
            1861-9541
            1001-6538
         volumeNumber:46
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Science in China Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Li Yuhua
            affiliation:
                  name:First Military Medical University
                  address:
                     name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Fudan University
                  address:
                     name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chen Hui
            affiliation:
                  name:Fudan University
                  address:
                     name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guo Kunyuan
            affiliation:
                  name:First Military Medical University
                  address:
                     name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Xie Yongmei
            affiliation:
                  name:Fudan University
                  address:
                     name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wang Feng
            affiliation:
                  name:Central Research Lab of First Hospital of Shanghai
                  address:
                     name:Central Research Lab of First Hospital of Shanghai, Shangshai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xie Kuangcheng
            affiliation:
                  name:Fudan University
                  address:
                     name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huang Jiangsheng
            affiliation:
                  name:Fudan University
                  address:
                     name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ren Daming
            affiliation:
                  name:Fudan University
                  address:
                     name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
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      name:Chinese Science Bulletin
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      volumeNumber:46
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      name:Science in China Press
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      name:First Military Medical University
      address:
         name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
         type:PostalAddress
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      address:
         name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
         type:PostalAddress
      name:First Military Medical University
      address:
         name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
         type:PostalAddress
      name:Central Research Lab of First Hospital of Shanghai
      address:
         name:Central Research Lab of First Hospital of Shanghai, Shangshai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
         type:PostalAddress
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         name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
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      affiliation:
            name:First Military Medical University
            address:
               name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
               type:PostalAddress
            type:Organization
            name:Fudan University
            address:
               name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
               type:PostalAddress
            type:Organization
      name:Chen Hui
      affiliation:
            name:Fudan University
            address:
               name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
               type:PostalAddress
            type:Organization
      name:Guo Kunyuan
      affiliation:
            name:First Military Medical University
            address:
               name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Xie Yongmei
      affiliation:
            name:Fudan University
            address:
               name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
               type:PostalAddress
            type:Organization
      name:Wang Feng
      affiliation:
            name:Central Research Lab of First Hospital of Shanghai
            address:
               name:Central Research Lab of First Hospital of Shanghai, Shangshai, China
               type:PostalAddress
            type:Organization
      name:Xie Kuangcheng
      affiliation:
            name:Fudan University
            address:
               name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
               type:PostalAddress
            type:Organization
      name:Huang Jiangsheng
      affiliation:
            name:Fudan University
            address:
               name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
               type:PostalAddress
            type:Organization
      name:Ren Daming
      affiliation:
            name:Fudan University
            address:
               name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
      name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
      name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
      name:Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou, China
      name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
      name:Central Research Lab of First Hospital of Shanghai, Shangshai, China
      name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
      name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
      name:Institute of Genetics, School of Life Science, State Key Laboratory of Genetic Engineering, Fudan University, Shangshai, China
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External Links {๐Ÿ”—}(62)

Analytics and Tracking {๐Ÿ“Š}

  • Google Tag Manager

Libraries {๐Ÿ“š}

  • Clipboard.js
  • Prism.js

CDN Services {๐Ÿ“ฆ}

  • Crossref

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