We are analyzing https://link.springer.com/article/10.1007/bf01833331.

Title:
Expression of IGF-I and IGF-II mRNA in breast tissue | Breast Cancer Research and Treatment
Description:
Expression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both the malignant epithelial cells and their adjacent stromal cells. These data imply that stromal cells associated with breast epithelium may switch expression from IGF-I to IGF-II during breast cancer evolution. This appearance of IGF-II expression may identify cancer-associated stromal cells that have a fetal phenotype.
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Keywords {🔍}

breast, cancer, cells, article, expression, igfii, google, scholar, igfi, mrna, stromal, pubmed, paik, human, growth, privacy, cookies, content, research, epithelial, insulinlike, data, publish, search, tumor, access, lippman, rosen, factor, analysis, information, log, journal, treatment, hybridization, malignant, fetal, discover, yee, cullen, res, download, springer, optional, personal, parties, policy, find, track, tissue,

Topics {✒️}

month download article/chapter human breast cancer breast cancer evolution malignant epithelial cells privacy choices/manage cookies gene expression human breast fibroblasts cold spring harbor lombardi cancer center growth factor ii full article pdf human rhabdomyosarcoma cells related subjects stromal cells adjacent adjacent stromal cells breast tissue published igf-ii expression igf-ii mrna european economic area normal human fetal breast cancer conditions privacy policy igf-1r transported situ hybridization study accepting optional cookies tumor cells journal finder publish cancer res 51 cancer res 48 growth factor growth factor biology stromal cells breast tissue tumor tissues situ hybridization insulin check access instant access identify cancer breast epithelium treatment aims article paik cullen kj yee article log igf-ii wilms' tumor privacy policy epithelial personal data

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         headline:Expression of IGF-I and IGF-II mRNA in breast tissue
         description:Expression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both the malignant epithelial cells and their adjacent stromal cells. These data imply that stromal cells associated with breast epithelium may switch expression from IGF-I to IGF-II during breast cancer evolution. This appearance of IGF-II expression may identify cancer-associated stromal cells that have a fetal phenotype.
         datePublished:
         dateModified:
         pageStart:31
         pageEnd:38
         sameAs:https://doi.org/10.1007/BF01833331
         keywords:
            breast tumor cells
            epithelial cells
            IGF-I
            IGF-II
            in-situ hybridization
            insulin-like growth factors
            messenger RNA
            stromal cells
            Oncology
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      headline:Expression of IGF-I and IGF-II mRNA in breast tissue
      description:Expression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both the malignant epithelial cells and their adjacent stromal cells. These data imply that stromal cells associated with breast epithelium may switch expression from IGF-I to IGF-II during breast cancer evolution. This appearance of IGF-II expression may identify cancer-associated stromal cells that have a fetal phenotype.
      datePublished:
      dateModified:
      pageStart:31
      pageEnd:38
      sameAs:https://doi.org/10.1007/BF01833331
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         epithelial cells
         IGF-I
         IGF-II
         in-situ hybridization
         insulin-like growth factors
         messenger RNA
         stromal cells
         Oncology
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