We are analyzing https://link.springer.com/article/10.1007/bf01831706.

Title:
Effect of catechins and citrus flavonoids on invasionin vitro | Clinical & Experimental Metastasis
Description:
Catechins, a group of flavonoid molecules, inhibit invasion of mouse MO4 cells into embryonic chick heart fragmentsin vitro. The anti-invasive effects can be ranked as follows: (+)-catechin > (−)-epicatechin>3-O-methyl-(+)-catechin > 3-O-palmitoyl-(+)-catechin. Most of the catechins are unstable in cell culture media, and their spontaneous rearrangement products tend to bind to extracellular matrix (ECM). Due to these interactions proteases such as tissue-type plasminogen activator (t-PA) are linked to the ECM glycoprotein laminin. This leads to a partial inactivation of the enzyme. Within the group of catechins we found a positive correlation between anti-invasive activity and linking of t-PA to laminin. Citrus flavonoids are also anti-invasivein vitro (tangeretin > nobiletin > hesperidin = naringin). However, these stable molecules show poor affinity for ECM, and do not link enzymes to laminin. These data suggest that catechins and citrus flavonoids inhibit invasionin vitro by different mechanisms.
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Keywords {🔍}

google, scholar, cell, pubmed, metastasis, article, invasionin, mareel, laminin, bracke, van, research, flavonoids, vitro, invasion, tumor, malignant, catechins, catechin, edited, privacy, cookies, content, experimental, vyncke, foidart, cells, chick, products, mechanisms, access, biochemical, data, journal, publish, search, clinical, effect, citrus, opdenakker, pestel, mouse, embryonic, plasminogen, adhesion, biological, chemistry, cauwenberge, andmareel, york,

Topics {✒️}

month download article/chapter s-carboxymethyl-l-cysteine tissue-type plasminogen activator cell adhesion proteins-laminin anti-invasive activity natural protease inhibitors tissue-type activator experimental cell research full article pdf chick heartin vitro privacy choices/manage cookies anti-invasivein vitro structure-activity relationships malignant invasionin vivo cell adhesion correlates tumor invasionin vitro mouse mo4 cells mo4 mouse cells invasionin vitro published anti-invasive effects anti-invasive flavonoid related subjects chemical pharmaceutical bulletin spontaneous mammary carcinomas mammary tumor virus malignant fibrosarcoma cells european economic area scope submit manuscript anticancer vinca alkaloid theβ-sheet formed cell culture media cell surface glycoproteins conditions privacy policy base rearrangement product acquired tumor resistance andvan den berghe murine sarcoma virus kidney invasion test cancer metastasis reviews national cancer institute accepting optional cookies check access proteolytic mechanisms operating instant access article bracke invasionin vitro article log major mechanism inhibit invasion experimental metastasis

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      headline:Effect of catechins and citrus flavonoids on invasionin vitro
      description:Catechins, a group of flavonoid molecules, inhibit invasion of mouse MO4 cells into embryonic chick heart fragmentsin vitro. The anti-invasive effects can be ranked as follows: (+)-catechin > (−)-epicatechin>3-O-methyl-(+)-catechin > 3-O-palmitoyl-(+)-catechin. Most of the catechins are unstable in cell culture media, and their spontaneous rearrangement products tend to bind to extracellular matrix (ECM). Due to these interactions proteases such as tissue-type plasminogen activator (t-PA) are linked to the ECM glycoprotein laminin. This leads to a partial inactivation of the enzyme. Within the group of catechins we found a positive correlation between anti-invasive activity and linking of t-PA to laminin. Citrus flavonoids are also anti-invasivein vitro (tangeretin > nobiletin > hesperidin = naringin). However, these stable molecules show poor affinity for ECM, and do not link enzymes to laminin. These data suggest that catechins and citrus flavonoids inhibit invasionin vitro by different mechanisms.
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      dateModified:
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         Epicatechin
         Naringin
         Hesperidin
         Cancer Research
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         general
         Oncology
         Hematology
         Surgical Oncology
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