We are analyzing https://link.springer.com/article/10.1007/bf01250085.

Title:
Post-mortem distribution of dopamine and homo-vanillic acid in human brain, variations related to age, and a review of the literature | Journal of Neural Transmission
Description:
The post-mortem brain concentrations of dopamine (DA) and homo-vanillic acid (HVA) were determined in 16 parts of the brain from patients with no history of neurologic or psychiatric illness. Fifteen men and nine women, with a mean age of 61.0±18.7 years (range 23–92 years) were included. They had died from either ischaemic heart disease or cancer. In the post-mortem investigation several factors were controlled: age, time between death and autopsy, time between autopsy and chemical analysis and storage time (−20 °C). The DA concentrations in the different brain areas were found to be positively intercorrelated, especially those in the basal ganglia, hippocampus and the mesencephalon. The HVA concentrations measured in various cortical structures were also positively intercorrelated. In several regions of the brain there was a significant inverse correlation between the DA and HVA concentrations. The DA and HVA concentrations did not differ according to sex, but age had a marked influence on the DA concentration. Significant decrease with age was observed in the nucleus caudatus, globus pallidus, mesencephalon, hippocampus and in the cortex gyrus hippocampus. These findings are discussed in relation to the effect of aging neurons. A review of human post-mortem investigations on DA and HVA concentrations is also presented.
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Keywords {🔍}

google, scholar, brain, human, dopamine, acid, acta, scand, homovanillic, gottfries, postmortem, article, distribution, age, roos, aging, physiol, winblad, neurons, carlsson, neural, related, concentrations, disease, monoamines, rat, psychiat, catecholamines, res, adolfsson, hva, cortex, access, enzymes, occurrence, determination, sci, fuxe, exp, hornykiewicz, privacy, cookies, content, journal, time, dementia, andén, fluorimetric, method, monoamine,

Topics {✒️}

month download article/chapter aromatic l-amino acid nigro-striatal dopamine neurons human post-mortem investigations human post-mortem material human post-mortem brain post-mortem brain concentrations biochemical post-mortem findings de la torre privacy choices/manage cookies full article pdf post-mortem measurement post-mortem specimens syndrome de parkinson l-dopa psychosis l-dopa therapy post-mortem investigation neural transmission aims post-mortem distribution homo-vanillic acid 4-hydroxy-3-methoxyphenylacetic acid european economic area scope submit manuscript related subjects diverse biological material quantitative histological studies unoin exchange separation mixed solvent elimination catechol-o-transferase ascending monoamine neurons aging male mice dopamine nerve terminals conditions privacy policy central nervous system check access instant access ischaemic heart disease initial mental disorders enzyme radiochemical assay neurology collaborative study aged human brain human brain responds homovanillic acid levels histochemical fluorescence study aging nervous system accepting optional cookies cerebral vascular disease glutamic acid decarboxylase preliminary biochemical study human cerebral cortex

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