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Title:
Linkage disequilibrium in finite populations | Theoretical and Applied Genetics
Description:
A theoretical investigation has been made of the influence of population size (N) and recombination fraction (c) on linkage disequilibrium (D) between a pair of loci. Two situations were studied: (i) where both loci had no effect on fitness and (ii) where they showed heterozygote superiority, but no epistacy. If the populations are initially in linkage equilibrium, then the mean value ofD remains zero with inbreeding, but the mean ofD 2 increases to a maximum value and decreases until fixation is reached at both loci. The tighter the linkage and the greater the selection, then the later is the maximum in the mean ofD 2 reached, and the larger its value. The correlation of gene frequencies,r, in the population of gametes within segregating lines was also studied. It was found that, for a range of selection intensities and initial gene frequencies, the mean value ofr 2 was determined almost entirely byN c and time, measured proportional toN. The implication of these results on observations of linkage disequilibrium in natural populations is discussed.
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Keywords {🔍}

linkage, genetics, google, scholar, article, selection, loci, robertson, populations, population, privacy, cookies, content, disequilibrium, hill, effect, inbreeding, access, information, publish, research, search, theoretical, genetic, data, log, journal, recombination, equilibrium, ofd, maximum, wert, vond, related, discover, download, springer, optional, analysis, personal, parties, policy, find, track, applied, finite, cite, alan, explore, investigation,

Topics {✒️}

auf das koppelungs-ungleichgewicht und der rekombinationsfraktion einem ursprünglichen koppelungsgleichgewicht es wurde gefunden bis die fixierung month download article/chapter population size jedoch keine epistasie theoretical investigation genetic variance related subjects privacy choices/manage cookies applied genetics aims linkage equilibrium national research council full article pdf natürlichen populationen diskutiert variation due article theoretical european economic area scope submit manuscript measured proportional ton natural populations gemessen proportional zun multi-allelic locus linkage disequilibrium conditions privacy policy showed heterozygote superiority check access instant access accepting optional cookies population initial gene frequencies article hill genomic selection accuracy locus viability selection main content log finite populations published treating inbreeding systems journal finder publish recombination fraction interaction article log privacy policy maximum personal data statistical genetics animal genetics books a article cite

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         description:A theoretical investigation has been made of the influence of population size (N) and recombination fraction (c) on linkage disequilibrium (D) between a pair of loci. Two situations were studied: (i) where both loci had no effect on fitness and (ii) where they showed heterozygote superiority, but no epistacy. If the populations are initially in linkage equilibrium, then the mean value ofD remains zero with inbreeding, but the mean ofD 2 increases to a maximum value and decreases until fixation is reached at both loci. The tighter the linkage and the greater the selection, then the later is the maximum in the mean ofD 2 reached, and the larger its value. The correlation of gene frequencies,r, in the population of gametes within segregating lines was also studied. It was found that, for a range of selection intensities and initial gene frequencies, the mean value ofr 2 was determined almost entirely byN c and time, measured proportional toN. The implication of these results on observations of linkage disequilibrium in natural populations is discussed.
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      headline:Linkage disequilibrium in finite populations
      description:A theoretical investigation has been made of the influence of population size (N) and recombination fraction (c) on linkage disequilibrium (D) between a pair of loci. Two situations were studied: (i) where both loci had no effect on fitness and (ii) where they showed heterozygote superiority, but no epistacy. If the populations are initially in linkage equilibrium, then the mean value ofD remains zero with inbreeding, but the mean ofD 2 increases to a maximum value and decreases until fixation is reached at both loci. The tighter the linkage and the greater the selection, then the later is the maximum in the mean ofD 2 reached, and the larger its value. The correlation of gene frequencies,r, in the population of gametes within segregating lines was also studied. It was found that, for a range of selection intensities and initial gene frequencies, the mean value ofr 2 was determined almost entirely byN c and time, measured proportional toN. The implication of these results on observations of linkage disequilibrium in natural populations is discussed.
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         Plant Biochemistry
         Biochemistry
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         Biotechnology
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