We are analyzing https://link.springer.com/article/10.1007/bf01215981.

Title:
Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines | Journal of Cancer Research and Clinical Oncology
Description:
Cellular adhesion to extracellular matrix proteins via integrin molecules is a major factor in the process of invasion and metastasis of human tumor cells. Four human prostate cell lines were characterized according to the presence and quantity of integrin subunits, the ability of the cells to attach to extracellular substrates and the capacity of the cells to form tumors in severe combined immunodeficient (SCID) mice. All four human prostate cell lines expressed three to five integrins on their cell surfaces. The DU145, PC3 and 431P cells expressed primarily α3, α5, and α6 integrin at similar levels. These cell lines expressed the subunits β1, β3 and β4 with β1 predominant. The DU145 cells preferred attachment to fibronectin, followed by laminin and vitronectin. Approximately 50%–60% of the binding of DU145 cells to fibronectin and laminin was dependent on the function of α5β1 and α6 respectively. The cell line LNCaP differed in its low expression of the α3 subunit, 95% of cellular adhesion to fobronectin and laminin being integrin-dependent and its inability to attach to vitronectin, in spite of surface expression of αvβ3. All the cell lines except for LNCaP readily formed tumors within SCID mice and the expression of α3, α6, β1, and β4 integrin subunits was preserved in the resulting tumor tissue. The altered adhesion properties of the LNCaP cells may explain their altered tumorigenicity.
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google, scholar, pubmed, cell, cancer, integrin, cells, human, prostate, adhesion, res, article, biol, receptor, fibronectin, expression, integrins, characterization, extracellular, metastasis, lines, matrix, tumor, carcinoma, arizona, mice, laminin, vitronectin, subunit, access, growth, privacy, cookies, content, journal, research, subunits, scid, αvβ, fibroblasts, chung, lwk, monoclonal, analysis, information, publish, search, oncology, cellular, invasion,

Topics {✒️}

month download article/chapter cell lines expressed prostate carcinoma growth human prostate cancer platelet glycoproteins ic-iia human lung cancer human prostatic carcinoma human tumor cells clinical oncology aims mediating cell adhesion fibronectin receptor-deficient cells rat prostate fibroblasts prostatic cancer growth privacy choices/manage cookies cell adhesion molecules humanprostate cancer growth full article pdf platelet glycoproteins ic tumor cell dissemination circulating tumor cells lymphocyte adhesion receptor severe combined immunodeficient resulting tumor tissue altered adhesion properties scid mouse mutant cell lines collagen receptor complexes platelet gpiib-iiia von eschenbach ac oncogenically transformed cells european economic area automated microfiltration device proteolytically processed keratins van der geer promotes bacterial penetration steele gd jr elastin repeat peptide kolmogorov-smirnov test cell adhesion conditions privacy policy distinct adhesive properties arizona cancer center o'toole te integrin β subunit unexpected subunit composition accepting optional cookies extracellular matrix proteins extracellular matrix components specific monoclonal antibodies check access

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      headline:Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines
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         Cell adhesion
         Human prostate cell lines
         Metastasis
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         Cancer Research
         Internal Medicine
         Hematology
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