We are analyzing https://link.springer.com/article/10.1007/bf00918814.

Title:
Arachidonic acid metabolites: Effects on inflammation of fetal rabbit excisional wounds | Inflammation
Description:
Uncovered fetal rabbit excisional wounds do not exhibit any classic signs of healing; wounds covered with an impermeable cover do contract, reepithelialize, and exhibit inflammation. Prostaglandin E2 (PGE2) is elevated in amniotic fluid, acting as an immunosuppressant at the maternal-fetal interface. Full-thickness excisional wounds were made on 25-day gestational age rabbit fetuses. Half the wounds were covered with an impermeable cover. Tissue from covered, uncovered, and nonwounded fetuses was examined 72 h after wounding for arachidonic acid metabolites. Uncovered wounds had significantly (P≤0.05) elevated levels of PGE2, PGE2α, and 12-HETE versus covered wounds and control tissue. Covered wounds had significantly elevated levels of 15-HETE compared to uncovered and control tissue. The elevated PGE2 in uncovered wounds may act as a fetal immunosuppressant; covered wounds (lower PGE2) developed cellular inflammation. Further investigations of these interactions may permit modulation of adult inflammation.
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Keywords {🔍}

google, scholar, fetal, wounds, inflammation, article, rabbit, amniotic, excisional, healing, covered, human, med, privacy, cookies, content, morykwas, uncovered, pge, fluid, tissue, access, surg, andr, skin, andm, publish, search, arachidonic, acid, effects, duell, ledbetter, argenta, elevated, cellular, open, intrauterine, immunol, inflammatory, chaouat, products, data, information, log, journal, research, metabolites, jennings, white,

Topics {✒️}

month download article/chapter arachidonic acid metabolites full-thickness excisional wounds amniotic fluid—research structure-activity relationship study open fetal surgery decidua-placenta immunologic interactions full article pdf amniotic fluid exclusion privacy choices/manage cookies excisional fetal wounds fetal excisional wounds adult wound healing prostaglandin e2 release article inflammation aims fetal tissue sampling related subjects natural killing activity human polymorphonuclear leukocytes maternal-fetal interface fetal intracardiac transfusions fetal diaphragmatic hernia fetal rhesus monkey european economic area 4-dioxothiazolidin-5-ylidene derivatives soluble factor secreted double bond positions folin phenol reagent severe rhesus isoimmunisation bowman gray school intra-uterine healing control tissue check access instant access acute inflammatory reaction amniotic fluid conditions privacy policy immunoregulatory factors secreted underivitized fatty acids san francisco experience acute phlogistic reactions lysosomal enzyme secretion accepting optional cookies dermatology lipidology mechanism developed cellular inflammation inherited skin diseases prostaglandin e2 main content log journal finder publish stephen ledbetter & louis

Schema {🗺️}

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         headline:Arachidonic acid metabolites: Effects on inflammation of fetal rabbit excisional wounds
         description:Uncovered fetal rabbit excisional wounds do not exhibit any classic signs of healing; wounds covered with an impermeable cover do contract, reepithelialize, and exhibit inflammation. Prostaglandin E2 (PGE2) is elevated in amniotic fluid, acting as an immunosuppressant at the maternal-fetal interface. Full-thickness excisional wounds were made on 25-day gestational age rabbit fetuses. Half the wounds were covered with an impermeable cover. Tissue from covered, uncovered, and nonwounded fetuses was examined 72 h after wounding for arachidonic acid metabolites. Uncovered wounds had significantly (P≤0.05) elevated levels of PGE2, PGE2α, and 12-HETE versus covered wounds and control tissue. Covered wounds had significantly elevated levels of 15-HETE compared to uncovered and control tissue. The elevated PGE2 in uncovered wounds may act as a fetal immunosuppressant; covered wounds (lower PGE2) developed cellular inflammation. Further investigations of these interactions may permit modulation of adult inflammation.
         datePublished:
         dateModified:
         pageStart:251
         pageEnd:258
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            Arachidonic Acid
            PGE2
            Amniotic Fluid
            Control Tissue
            Immunology
            Rheumatology
            Pharmacology/Toxicology
            Pathology
            Internal Medicine
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      headline:Arachidonic acid metabolites: Effects on inflammation of fetal rabbit excisional wounds
      description:Uncovered fetal rabbit excisional wounds do not exhibit any classic signs of healing; wounds covered with an impermeable cover do contract, reepithelialize, and exhibit inflammation. Prostaglandin E2 (PGE2) is elevated in amniotic fluid, acting as an immunosuppressant at the maternal-fetal interface. Full-thickness excisional wounds were made on 25-day gestational age rabbit fetuses. Half the wounds were covered with an impermeable cover. Tissue from covered, uncovered, and nonwounded fetuses was examined 72 h after wounding for arachidonic acid metabolites. Uncovered wounds had significantly (P≤0.05) elevated levels of PGE2, PGE2α, and 12-HETE versus covered wounds and control tissue. Covered wounds had significantly elevated levels of 15-HETE compared to uncovered and control tissue. The elevated PGE2 in uncovered wounds may act as a fetal immunosuppressant; covered wounds (lower PGE2) developed cellular inflammation. Further investigations of these interactions may permit modulation of adult inflammation.
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      dateModified:
      pageStart:251
      pageEnd:258
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         Arachidonic Acid
         PGE2
         Amniotic Fluid
         Control Tissue
         Immunology
         Rheumatology
         Pharmacology/Toxicology
         Pathology
         Internal Medicine
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