We are analyzing https://link.springer.com/article/10.1007/bf00868525.

Title:
Effects of long-term treatment in Wilson's disease withd-penicillamine and zinc sulphate | Journal of Neurology
Description:
Journal of Neurology - The results of treatment withd-penicillamine (d-P) or zinc sulphate (Zn) in 67 newly diagnosed cases of Wilson
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Keywords {🔍}

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Topics {✒️}

month download article/chapter privacy choices/manage cookies related subjects long-term care full article pdf long-term treatment continuous zinc therapy oral zinc therapy van der wiel interrupting penicillamine therapy european economic area march 1996 volume 243 triethylene tetramine dihydrochloride initial penicillamine therapy conditions privacy policy check access instant access zinc sulphate article czlonkowska treatment withd-penicillamine longterm treatment withd walshe jm hepato-cerebral degeneration accepting optional cookies d-penicillamine disease withd-penicillamine initial penicillamine chelation journal finder publish received zn deteriorated fatal deterioration wilson' main content log zinc therapy article journal manchester university press patients discontinued zn cumings jn article log oral therapy initial therapy article cite privacy policy personal data books a van hattum combination therapy penicillamine treatment optional cookies manage preferences d penicillamine nephropathy

Schema {🗺️}

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         headline:Effects of long-term treatment in Wilson's disease withd-penicillamine and zinc sulphate
         description:The results of treatment withd-penicillamine (d-P) or zinc sulphate (Zn) in 67 newly diagnosed cases of Wilson's disease have been compared. All patients (7 with hepatic, 1 with psychiatric and 59 with neurological or preclinical forms) were fully compliant. During 12 years of observation, 34 patients receivedd-P and 33 Zn as the primary treatment. Fifteen patients (44%) discontinuedd-P, in 10 cases owing to side effects. Four (12%) patients discontinued Zn, in 2 cases because of side-effects. One patient who received Zn deteriorated during the first few months after the initiation of therapy. The effectiveness of longterm treatment withd-P and Zn was similar in those patients who were able to continue the initial therapy. Zn was tolerated better thand-P; we suggest, therefore, that it may be recommended as an initial therapy for patients in the preclinical stage of Wilson's disease or with neurological presentation of the disease. More observation is needed for patients with the hepatic and psychiatric forms of the disease.
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      description:The results of treatment withd-penicillamine (d-P) or zinc sulphate (Zn) in 67 newly diagnosed cases of Wilson's disease have been compared. All patients (7 with hepatic, 1 with psychiatric and 59 with neurological or preclinical forms) were fully compliant. During 12 years of observation, 34 patients receivedd-P and 33 Zn as the primary treatment. Fifteen patients (44%) discontinuedd-P, in 10 cases owing to side effects. Four (12%) patients discontinued Zn, in 2 cases because of side-effects. One patient who received Zn deteriorated during the first few months after the initiation of therapy. The effectiveness of longterm treatment withd-P and Zn was similar in those patients who were able to continue the initial therapy. Zn was tolerated better thand-P; we suggest, therefore, that it may be recommended as an initial therapy for patients in the preclinical stage of Wilson's disease or with neurological presentation of the disease. More observation is needed for patients with the hepatic and psychiatric forms of the disease.
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