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Title:
Transport of calcium by mitochondria | Journal of Bioenergetics and Biomembranes
Description:
The identification of intramitochondrial free calcium ([Ca2+ m) as a primary metabolic mediator [see Hansford (this volume) and Gunter, T. E., Gunter, K. K., Sheu, S.-S., and Gavin, C. E. (1994)Am. J. Physiol. 267, C313–C339, for reviews] has emphasized the importance of understanding the characteristics of those mechanisms that control [Ca2+]m. In this review, we attempt to update the descriptions of the mechanisms that mediate the transport of Ca2+ across the mitochondrial inner membrane, emphasizing the energetics of each mechanism. New concepts within this field are reviewed and some older concepts are discussed more completely than in earlier reviews. The mathematical forms of the membrane potential dependence and concentration dependence of the uniporter are interpolated in such a way as to display the convenience of consideringV max to be an explicit function of the membrane potential. Recent evidence for a transient rapid conductance state of the uniporter is discussed. New evidence concerning the energetics and stoichiometries of both Na+-dependent and Na+-independent efflux mechanisms is reviewed. Explicit mathematical expressions are used to describe the energetics of the system and the kinetics of transport via each Ca2+ transport mechanism.
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google, scholar, gunter, biochem, biol, biophys, chem, acta, transport, calcium, lett, article, physiol, carafoli, biochim, crompton, york, pfeiffer, febs, azzone, eur, brierley, arch, lehninger, rochester, biochemistry, privacy, cookies, content, journal, mitochondria, gavin, åkerman, bioenerg, adv, fiskum, publish, research, search, metabolic, mechanisms, membrane, access, biomembr, bfebs, bernardi, berridge, nature, london, brand,
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month download article/chapter na+-independent efflux mechanisms signalling pathways privacy choices/manage cookies intramitochondrial free calcium inintracellular calcium regulation full article pdf ca2+ transport mechanism calcium transport membrane potential dependence european economic area related subjects incalcium binding proteins elsevier/north-holland �parathyroid hormone activation growth plate chondrocytes” conditions privacy policy mitochondria published accepting optional cookies explicit mathematical expressions scientific foundations vol journal finder publish check access instant access main content log article journal rochester medical school membrane potential glynn research metabolic processes metabolic turnover article log mitochondria mitochondrial kinetics electron transport article gunter article cite mcmillin-wood control [ca2+] privacy policy personal data gunter rights books a calcium optional cookies manage preferences na+-dependent journal publish data protection
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headline:Transport of calcium by mitochondria
description:The identification of intramitochondrial free calcium ([Ca2+
m) as a primary metabolic mediator [see Hansford (this volume) and Gunter, T. E., Gunter, K. K., Sheu, S.-S., and Gavin, C. E. (1994)Am. J. Physiol.
267, C313–C339, for reviews] has emphasized the importance of understanding the characteristics of those mechanisms that control [Ca2+]m. In this review, we attempt to update the descriptions of the mechanisms that mediate the transport of Ca2+ across the mitochondrial inner membrane, emphasizing the energetics of each mechanism. New concepts within this field are reviewed and some older concepts are discussed more completely than in earlier reviews. The mathematical forms of the membrane potential dependence and concentration dependence of the uniporter are interpolated in such a way as to display the convenience of consideringV
max to be an explicit function of the membrane potential. Recent evidence for a transient rapid conductance state of the uniporter is discussed. New evidence concerning the energetics and stoichiometries of both Na+-dependent and Na+-independent efflux mechanisms is reviewed. Explicit mathematical expressions are used to describe the energetics of the system and the kinetics of transport via each Ca2+ transport mechanism.
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keywords:
Mitochondria
transport
calcium
metabolic mediator
kinetics
calcium pulses
Bioorganic Chemistry
Biochemistry
general
Animal Anatomy / Morphology / Histology
Animal Biochemistry
Organic Chemistry
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headline:Transport of calcium by mitochondria
description:The identification of intramitochondrial free calcium ([Ca2+
m) as a primary metabolic mediator [see Hansford (this volume) and Gunter, T. E., Gunter, K. K., Sheu, S.-S., and Gavin, C. E. (1994)Am. J. Physiol.
267, C313–C339, for reviews] has emphasized the importance of understanding the characteristics of those mechanisms that control [Ca2+]m. In this review, we attempt to update the descriptions of the mechanisms that mediate the transport of Ca2+ across the mitochondrial inner membrane, emphasizing the energetics of each mechanism. New concepts within this field are reviewed and some older concepts are discussed more completely than in earlier reviews. The mathematical forms of the membrane potential dependence and concentration dependence of the uniporter are interpolated in such a way as to display the convenience of consideringV
max to be an explicit function of the membrane potential. Recent evidence for a transient rapid conductance state of the uniporter is discussed. New evidence concerning the energetics and stoichiometries of both Na+-dependent and Na+-independent efflux mechanisms is reviewed. Explicit mathematical expressions are used to describe the energetics of the system and the kinetics of transport via each Ca2+ transport mechanism.
datePublished:
dateModified:
pageStart:471
pageEnd:485
sameAs:https://doi.org/10.1007/BF00762732
keywords:
Mitochondria
transport
calcium
metabolic mediator
kinetics
calcium pulses
Bioorganic Chemistry
Biochemistry
general
Animal Anatomy / Morphology / Histology
Animal Biochemistry
Organic Chemistry
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