We are analyzing https://link.springer.com/article/10.1007/bf00731309.

Title:
Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22 | Glycoconjugate Journal
Description:
An increasing number of mammalian cell adhesion molecules, including sialoadhesion, CD22 and the family of selectins, have been found to bind cell surface glycoconjugates containing sialic acids. Here we describe how the structural diversity of this sugar influences cell adhesion mediated by the related molecules sialoadhesin and CD22 in murine macrophages and B-cells respectively. We show that the 9-O-acetyl group of Neu5,9Ac2 and theN-glycoloyl residue of Neu5Gc interfere with sialoadhesin binding. In contrast, CD22 binds more strongly to Neu5Gc compared to Neu5Ac. Of two synthetic sialic acids tested, only CD22 bound theN-formyl derivative, whereas aN-trifluoroacetyl residue was accepted by sialoadhesin. The potential significance for the regulation of sialic acid dependent cell adhesion phenomena is discussed.
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Topics {✒️}

n-glycolylneuraminic acid month download article/chapter 9-o-acetyl group de souza-e-silva jean-claude manuguerra sialic acids privacy choices/manage cookies full article pdf check access instant access european economic area kluwer academic publishers john radcliffe hospital journal finder publish conditions privacy policy c2c12 myoblast cells cd22-binding sialosides cell biol 126 accepting optional cookies related molecules sialoadhesin cell adhesiveness main content log roland schauer crocker pr article kelm institut pasteur article log powell ld related subjects cell 66 cell 67 wilson gl sjoberg er article cite journal publish privacy policy personal data curr biol 4 books a draves ke de bellard rogers gn optional cookies biol chem 268 biol chem 269 biol chem 261 biol chem 257 biol chem 267 manage preferences including sialoadhesion

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      description:An increasing number of mammalian cell adhesion molecules, including sialoadhesion, CD22 and the family of selectins, have been found to bind cell surface glycoconjugates containing sialic acids. Here we describe how the structural diversity of this sugar influences cell adhesion mediated by the related molecules sialoadhesin and CD22 in murine macrophages and B-cells respectively. We show that the 9-O-acetyl group of Neu5,9Ac2 and theN-glycoloyl residue of Neu5Gc interfere with sialoadhesin binding. In contrast, CD22 binds more strongly to Neu5Gc compared to Neu5Ac. Of two synthetic sialic acids tested, only CD22 bound theN-formyl derivative, whereas aN-trifluoroacetyl residue was accepted by sialoadhesin. The potential significance for the regulation of sialic acid dependent cell adhesion phenomena is discussed.
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