We are analyzing https://link.springer.com/article/10.1007/bf00690601.

Title:
Modulation of tumor cell gene expression and phenotype by the organspecific metastatic environment | Cancer and Metastasis Reviews
Description:
Cancer and Metastasis Reviews - The mechanistic basis of a metastatic cell
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

google, scholar, cancer, human, growth, cell, cells, res, expression, factor, metastasis, receptor, gene, tumor, melanoma, epidermal, fidler, metastatic, resistance, natl, colon, radinsky, biol, multidrug, nature, murine, inst, carcinoma, mouse, article, regulation, hormone, fan, sci, receptors, usa, apoptosis, acad, vogelstein, pglycoprotein, organspecific, organ, differentiation, rev, nude, mice, bucana, clin, proc, function,

Topics {✒️}

α-melanocyte-stimulating hormone receptors melanocyte-stimulating hormone receptor melanocyte-stimulating hormone responsive receptor-tyrosine kinases expression month download article/chapter develop organ-specific metastases increased mdr-1/p-glycoprotein expression wild-type human p53 organ-specific metastatic site antireceptor monoclonal antibodies paraffin-embedded surgical specimens distinct p-glycoprotein precursors epidermal growth factor tumour necrosis factor transforming growth factor p-glycoprotein predict response autocrine/paracrine growth factors mousemdr gene family privacy choices/manage cookies human colon carcinoma human colon carcinomas experimental metastasis correlates colon carcinoma cells gene expression signatures receptor proteintyrosine kinases wild type p53 wild-type p53 site specific metastasis site-specific metastasis tissue-specific manner brain tumour progression p53 mutant cells tgf-α-pe38 organ-specific modulation multidrug resistance gene cultured human melanocytes mutant p53 proteins mdr1 rna levels intracranial human glioma steadystatemdr gene expression metastasis reviews aims p53 gene occur human melanoma cells experimental lung metastases bone gla-protein msh receptor expression human cancer metastasis human multidrug resistance radiation-induced apoptosis multidrug-resistant cells

Questions {❓}

Dalton WS, Grogan TM: Does P-glycoprotein predict response to chemotherapy, and if so, is there a reliable way to detect it?
Kerbel RS, Kobayashi H, Graham CH: Intrinsic or acquired drug resistance and metastasis: Are they linked phenotypes?

Schema {🗺️}

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         description:The mechanistic basis of a metastatic cell's ability to proliferate in the parenchyma of certain organs and develop organ-specific metastases is under intense investigation. Signals from paracrine or autocrine pathways, alone or in combination, may regulate tumor cell proliferation with the eventual outcome dependent on the net balance of stimulatory and inhibitory factors. This article summarizes recent reports from our laboratory and others demonstrating that the organ microenvironment can profoundly influence the pattern of gene expression and the biological phenotype of metastatic tumor cells, including induction of melanocyte stimulating hormone receptor and production of melanin, regulation of terminal differentiation and apoptosis, resistance to chemotherapy, and regulation of growth at the organ-specific metastatic site. These recent data from both murine and human tumor models support the concept that the microenvironment of different organs can influence the pattern of gene expression and hence the phenotype of tumor cells at different steps of the metastatic process. These findings have obvious implications for the therapy of neoplasms in general and metastases in particular.
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