We are analyzing https://link.springer.com/article/10.1007/bf00689638.

Title:
P-glycoprotein, multidrug resistance and tumor progression | Cancer and Metastasis Reviews
Description:
P-glycoprotein (Pgp) is a plasma membrane protein that was first characterised in multidrug resistant cell lines. The occurrence of Pgp in clinical tumors has been widely studied. Recent investigations have begun to focus on the relationship between Pgp detection in tumors and treatment outcome. In several types of tumors, detection of Pgp correlates with poor response to chemotherapy and shorter survival. P-glycoprotein overexpression often occurs upon relapse from chemotherapy but may also occur at the time of diagnosis. Studies of experimental rat liver carcinogenesis have shown that Pgp expression increases in late stages of carcinogenesis, suggesting that Pgp may be involved in tumor progression. While some of the Pgp isoforms are known to transport hydrophobic chemotherapeutic drugs out of tumor cells, the biologic effects of Pgp overexpression in tumor cells are not fully understood, because the spectrum of substrates for Pgp-mediated transport has not been determined. In the rat liver carcinoma model, strong expression of Pgp is associated with a highly vascular stroma, suggesting that Pgp in tumor cells may affect the connective tissue stroma. The regulation of Pgp appears to be complex, and little is known about how it is up-regulated during carcinogenesis. Further studies of the role of Pgp in malignancy may contribute to our understanding of molecular mechanisms which underlie tumor progression.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

google, scholar, pglycoprotein, multidrug, resistance, expression, cell, cancer, gene, ling, human, pgp, article, tumor, bradley, rat, blood, res, cells, progression, liver, carcinogenesis, biol, mdr, mol, privacy, cookies, content, lines, tumors, chemotherapy, carcinoma, access, cellular, pastan, gottesman, journal, publish, search, metastasis, clinical, transporter, chem, normal, van, toronto, data, information, log, research,

Topics {✒️}

month download article/chapter retinoic acid-induced differentiation natural p-gp inhibitor virus-positive hepatocellular carcinomas cell surface p-glycoprotein multidrug resistance p-glycoprotein multidrug-resistance gene expression rat mdr2 gene mammalian cell lines privacy choices/manage cookies multidrug resistance gene human cancer metastasis human colon carcinoma multidrug resistance protein acquired trait related p-glycoprotein gene metastasis reviews aims mhc-linked transporter full article pdf drug resistance gene multidrug resistance malignancies mediated multidrug resistance mouse multidrug resistance related subjects primary hepatocyte cultures plasma membrane protein mdr3/mdr1a gene van roon ma human mdr1 gene therapeutic implications lymph node metastasis virus transgenic mice p-glycoprotein isoforms p-glycoprotein expression normal human tissues fluorescent cellular indicators p53 gene dosage european economic area highly vascular stroma connective tissue stroma tissue specific manner o'brien jp oude elferink rpj high-dose verapamil 3-methylcholanthrene-mediated induction clinical drug resistance p-glycoprotein overexpression mdr-1/p-glycoprotein conditions privacy policy p-glycoprotein genes

Questions {❓}

Endicott JA, Ling V: The biochemistry of P-glycoprotein?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:P-glycoprotein, multidrug resistance and tumor progression
         description:P-glycoprotein (Pgp) is a plasma membrane protein that was first characterised in multidrug resistant cell lines. The occurrence of Pgp in clinical tumors has been widely studied. Recent investigations have begun to focus on the relationship between Pgp detection in tumors and treatment outcome. In several types of tumors, detection of Pgp correlates with poor response to chemotherapy and shorter survival. P-glycoprotein overexpression often occurs upon relapse from chemotherapy but may also occur at the time of diagnosis. Studies of experimental rat liver carcinogenesis have shown that Pgp expression increases in late stages of carcinogenesis, suggesting that Pgp may be involved in tumor progression. While some of the Pgp isoforms are known to transport hydrophobic chemotherapeutic drugs out of tumor cells, the biologic effects of Pgp overexpression in tumor cells are not fully understood, because the spectrum of substrates for Pgp-mediated transport has not been determined. In the rat liver carcinoma model, strong expression of Pgp is associated with a highly vascular stroma, suggesting that Pgp in tumor cells may affect the connective tissue stroma. The regulation of Pgp appears to be complex, and little is known about how it is up-regulated during carcinogenesis. Further studies of the role of Pgp in malignancy may contribute to our understanding of molecular mechanisms which underlie tumor progression.
         datePublished:
         dateModified:
         pageStart:223
         pageEnd:233
         sameAs:https://doi.org/10.1007/BF00689638
         keywords:
            P-glycoprotein
            multidrug resistance
            rat liver carcinogenesis
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
               0167-7659
            volumeNumber:13
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Kluwer Academic Publishers
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Grace Bradley
               affiliation:
                     name:University of Toronto
                     address:
                        name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
                        type:PostalAddress
                     type:Organization
                     name:University of Toronto
                     address:
                        name:Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Victor Ling
               affiliation:
                     name:University of Toronto
                     address:
                        name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:P-glycoprotein, multidrug resistance and tumor progression
      description:P-glycoprotein (Pgp) is a plasma membrane protein that was first characterised in multidrug resistant cell lines. The occurrence of Pgp in clinical tumors has been widely studied. Recent investigations have begun to focus on the relationship between Pgp detection in tumors and treatment outcome. In several types of tumors, detection of Pgp correlates with poor response to chemotherapy and shorter survival. P-glycoprotein overexpression often occurs upon relapse from chemotherapy but may also occur at the time of diagnosis. Studies of experimental rat liver carcinogenesis have shown that Pgp expression increases in late stages of carcinogenesis, suggesting that Pgp may be involved in tumor progression. While some of the Pgp isoforms are known to transport hydrophobic chemotherapeutic drugs out of tumor cells, the biologic effects of Pgp overexpression in tumor cells are not fully understood, because the spectrum of substrates for Pgp-mediated transport has not been determined. In the rat liver carcinoma model, strong expression of Pgp is associated with a highly vascular stroma, suggesting that Pgp in tumor cells may affect the connective tissue stroma. The regulation of Pgp appears to be complex, and little is known about how it is up-regulated during carcinogenesis. Further studies of the role of Pgp in malignancy may contribute to our understanding of molecular mechanisms which underlie tumor progression.
      datePublished:
      dateModified:
      pageStart:223
      pageEnd:233
      sameAs:https://doi.org/10.1007/BF00689638
      keywords:
         P-glycoprotein
         multidrug resistance
         rat liver carcinogenesis
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
            0167-7659
         volumeNumber:13
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Kluwer Academic Publishers
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Grace Bradley
            affiliation:
                  name:University of Toronto
                  address:
                     name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
                     type:PostalAddress
                  type:Organization
                  name:University of Toronto
                  address:
                     name:Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Victor Ling
            affiliation:
                  name:University of Toronto
                  address:
                     name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:13
Organization:
      name:Kluwer Academic Publishers
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Toronto
      address:
         name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
         type:PostalAddress
      name:University of Toronto
      address:
         name:Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
         type:PostalAddress
      name:University of Toronto
      address:
         name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Grace Bradley
      affiliation:
            name:University of Toronto
            address:
               name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
               type:PostalAddress
            type:Organization
            name:University of Toronto
            address:
               name:Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
               type:PostalAddress
            type:Organization
      name:Victor Ling
      affiliation:
            name:University of Toronto
            address:
               name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
      name:Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
      name:Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(72)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.23s.

LINK . SPRINGER . COM {}