We are analyzing https://link.springer.com/article/10.1007/bf00685250.

Title:
An immunohistochemical study of myelin proteins during remyelination in the central nervous system | Acta Neuropathologica
Description:
The process of remyelination in the superior cerebellar peduncles of mice following demyelination with Cuprizone was studied immunohistochemically using antisera to myelin basic protein (MBP) and myelin-associated glycoprotein (MAG). Demyelination occurred after formation of myelinic vacuoles and resulted in almost complete loss of demonstrable MBP and MAG from the peduncle. Prior to the onset of remyelination, oligodendrocytes with cytoplasmic staining for both proteins appeared in the peduncle. These cells were then associated with remyelinating axons. The axons were remyelinated in clusters until the MBP and the MAG in the whole peduncle were reconstituted, although the axon sheaths were thinner than those in normal animals. The results show that the immunohistochemical distribution of MBP and MAG in remyelinating axons resembles that in normal axons, and that the expression of myelin proteins in oligodendrocytes during remyelination reverts to that seen during normal development.
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Keywords {🔍}

google, scholar, remyelination, myelin, demyelination, protein, central, nervous, system, basic, article, neurol, study, sternberger, webster, experimental, ludwin, access, neuropathol, itoyama, myelinassociated, glycoprotein, mag, oligodendrocytes, sci, allergic, encephalomyelitis, privacy, cookies, content, proteins, cuprizone, peduncle, axons, exp, immunocytochemical, lab, invest, hdef, information, publish, research, search, acta, immunohistochemical, mbp, open, blakemore, brain, usa,

Topics {✒️}

month download article/chapter related subjects full article pdf privacy choices/manage cookies experimental allergic encephalomyelitis brain research institute central nervous system identify basic protein myelin basic protein human nervous system glycoprotein demonstrated immunocytochemically peripheral nervous system rabbit spinal cord single-cell demyelination september 1984 volume 63 myelin-forming oligodendrocytes european economic area scope submit manuscript superior cerebellar peduncles higher throughput workflow inbred guinea pigs newborn rat cns ethidium bromide injection conditions privacy policy oligodendrocyte degeneration human fetal brain myelin sheath formation myelin-forming cells check access glycoprotein access instant access electron microscope study accepting optional cookies richardson ep jr electron-microscopic observations rochester medical school superior cerebellar peduncle article ludwin article log multiple sclerosis lesions journal finder publish remyelinating axons resembles raine cs basic protein article cite acta neuropathol acta neuropathol 63 ludwin sk sternberger nh cell biol 95

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         description:The process of remyelination in the superior cerebellar peduncles of mice following demyelination with Cuprizone was studied immunohistochemically using antisera to myelin basic protein (MBP) and myelin-associated glycoprotein (MAG). Demyelination occurred after formation of myelinic vacuoles and resulted in almost complete loss of demonstrable MBP and MAG from the peduncle. Prior to the onset of remyelination, oligodendrocytes with cytoplasmic staining for both proteins appeared in the peduncle. These cells were then associated with remyelinating axons. The axons were remyelinated in clusters until the MBP and the MAG in the whole peduncle were reconstituted, although the axon sheaths were thinner than those in normal animals. The results show that the immunohistochemical distribution of MBP and MAG in remyelinating axons resembles that in normal axons, and that the expression of myelin proteins in oligodendrocytes during remyelination reverts to that seen during normal development.
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      headline:An immunohistochemical study of myelin proteins during remyelination in the central nervous system
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