We are analyzing https://link.springer.com/article/10.1007/bf00294021.

Title:
Leukocytes in the urine after intravesical BCG treatment for superficial bladder cancer | Urolithiasis
Description:
Cellular immunologic reactions occurring in the bladder after intravesical treatment with bacillus Calmette-Guérin (BCG) were investigated by flow cytofluorometric analysis of leukocytes present in the urine. Urine specimens from 11 superficial bladder cancer patients were collected before and 5, 24, 48 and 72 h after repeated BCG instillations. Monoclonal antibodies specific for granulocytes, monocytes/macrophages, and T-and B-lymphocytes were used to characterize and quantify leukocyte subpopulations. The total number of cells in urine was found to be 2- to 485-fold increased 24 h after BCG administration. The predominant cell type present was the polymorphonuclear granulocyte, probably representing a defense mechanism against mycobacteria. The main mononuclear leukocytes in urine specimens were monocytes/macrophages and T-lymphocytes, indicating an ongoing immune response in the bladder wall. Although percentages of lymphocytes were low, T- and B-cells could be identified using a selective cell measurement procedure. In conclusion, a clear increase in the numbers of granulocytes, monocytes/macrophages and T-lymphocytes in urine after intravesical BCG administration was demonstrated, indicating local activation of the immune system.
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Keywords {🔍}

bladder, google, scholar, bcg, cancer, urine, article, intravesical, superficial, treatment, van, meijden, bacillus, urol, jong, calmetteguérin, leukocytes, steerenberg, debruyne, ruitenberg, access, privacy, cookies, content, research, boer, urology, apm, netherlands, publish, search, cells, cell, fmj, res, ratliff, analysis, data, information, log, journal, flow, vegt, cellular, patients, granulocytes, monocytesmacrophages, administration, immune, open,

Topics {✒️}

month download article/chapter cellular reaction flow cytofluorometric analysis intracavitary bacillus calmette-guérin intravesical bcg therapy bacillus calmette-guérin treatment related subjects superficial bladder cancer bacillus calmette-guérin urine sediment van der meijden full article pdf privacy choices/manage cookies superficial bladder tumors human bladder washings thiotepa treated bladders hla-dr expression urothelial bladder tumors advanced bladder carcinoma main mononuclear leukocytes de jong wh van leeuwen mjw check access instant access transitional cell carcinoma bcg-reactive responses intravesical bcg administration bladder cancer repeated bcg instillations european economic area scope submit manuscript quantify leukocyte subpopulations indicating local activation rabbit pleural spaces anti-tumor agent randomized prospective trial intravesical bcg treatment conditions privacy policy ongoing immune response de boer ec t-cell infiltration accepting optional cookies endovesical bcg-immunotherapy monoclonal antibodies specific mammalian immune system article log journal finder publish february 1991 volume 19 therapeutic model cancer immunotherapy

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         description:Cellular immunologic reactions occurring in the bladder after intravesical treatment with bacillus Calmette-Guérin (BCG) were investigated by flow cytofluorometric analysis of leukocytes present in the urine. Urine specimens from 11 superficial bladder cancer patients were collected before and 5, 24, 48 and 72 h after repeated BCG instillations. Monoclonal antibodies specific for granulocytes, monocytes/macrophages, and T-and B-lymphocytes were used to characterize and quantify leukocyte subpopulations. The total number of cells in urine was found to be 2- to 485-fold increased 24 h after BCG administration. The predominant cell type present was the polymorphonuclear granulocyte, probably representing a defense mechanism against mycobacteria. The main mononuclear leukocytes in urine specimens were monocytes/macrophages and T-lymphocytes, indicating an ongoing immune response in the bladder wall. Although percentages of lymphocytes were low, T- and B-cells could be identified using a selective cell measurement procedure. In conclusion, a clear increase in the numbers of granulocytes, monocytes/macrophages and T-lymphocytes in urine after intravesical BCG administration was demonstrated, indicating local activation of the immune system.
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            Bladder cancer
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            Cellular immunological reaction
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            Medical Biochemistry
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      headline:Leukocytes in the urine after intravesical BCG treatment for superficial bladder cancer
      description:Cellular immunologic reactions occurring in the bladder after intravesical treatment with bacillus Calmette-Guérin (BCG) were investigated by flow cytofluorometric analysis of leukocytes present in the urine. Urine specimens from 11 superficial bladder cancer patients were collected before and 5, 24, 48 and 72 h after repeated BCG instillations. Monoclonal antibodies specific for granulocytes, monocytes/macrophages, and T-and B-lymphocytes were used to characterize and quantify leukocyte subpopulations. The total number of cells in urine was found to be 2- to 485-fold increased 24 h after BCG administration. The predominant cell type present was the polymorphonuclear granulocyte, probably representing a defense mechanism against mycobacteria. The main mononuclear leukocytes in urine specimens were monocytes/macrophages and T-lymphocytes, indicating an ongoing immune response in the bladder wall. Although percentages of lymphocytes were low, T- and B-cells could be identified using a selective cell measurement procedure. In conclusion, a clear increase in the numbers of granulocytes, monocytes/macrophages and T-lymphocytes in urine after intravesical BCG administration was demonstrated, indicating local activation of the immune system.
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         Medical Biochemistry
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