We are analyzing https://link.springer.com/article/10.1007/bf02738068.

Title:
A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs) | Cell Biochemistry and Biophysics
Description:
A missing component in the experimental analysis of cell signaling by extracellular lysophospholipids such as lysophosphatidic acid (LPA) or sphingosine-1-phosphate (S1P) has been cloned receptors. Through studies on the developing brain, the first such receptor gene (referred to asvzg-1) was identified, representing a member of the G-protein coupled receptor (GPCR) super family(1). Here we review the neurobiological approach that led to both its cloning and identification as a receptor for LPA, along with related expression data. Summarized sequence and genomic structure analyses indicate that this first, functionally identified receptor is encoded by a member of a growing gene family that divides into at least two subgroups: genes most homologous to the high-affinity LPA receptor encoded byvzg-1, and those more homologous to an orphan receptor geneedg-1 that has recently been identified as a S1P receptor. A provisional nomenclature is proposed, based on published functional ligand actions, amino acid composition and genomic structure whereby the receptors encoded by these genes are referred to as lysophospholipid (LP) receptors, with subgroups distinguished by letter and number subscripts (e.g., LPA1 for Vzg-1, and LPB1 for Edg-1). Presented expression data support the recently published work indicating that members of the LPB1 subgroup are receptors for the structurally-related molecule, S1P. The availability of cloned LP receptors will enhance the analysis of the many documented LP effects, while their prominent expression in the nervous system indicates significant but as yet unknown roles in development, normal function, and neuropathology.
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Keywords {🔍}

google, scholar, article, cas, pubmed, receptor, lysophosphatidic, cell, acid, chun, receptors, cloning, lpa, gene, biol, growth, edg, human, gprotein, access, cells, weiner, biophys, res, hla, family, contos, coupled, identification, cerebral, proteincoupled, sci, moolenaar, chem, death, characterization, gproteincoupled, neurol, privacy, cookies, content, analysis, data, jerold, expression, sequence, nervous, mouse, cortical, neural,

Topics {✒️}

g-protein-coupled receptor edg-1 mammalian g-protein-coupled receptors g-protein-coupled receptors semi-quantitative ligation-mediated pcr g-protein coupled receptor protein-coupled receptor expressed protein-coupled receptor family month download article/chapter position-specific gap penalties protein-coupled receptors g-protein signalling modulates long-term potentiation protein-coupled receptor receptor-mediated lysophosphatidic acid endogenous cannabinoid ligands—chemical interkinetic nuclear migration low affinity agonist fetal cerebral cortex article cell biochemistry high-affinity receptor developing cerebral cortex human edg2 protein full article pdf native cb1 receptors fetal mammalian cns platelet surface receptor lysophosphatidic acid signalling fibroblast growth factor-1 edg-2/vzg-1 couples nerve growth factor privacy choices/manage cookies n18tg2 neuroblastoma cells cloned lp receptors encode odorant receptors mammalian embryonic development noradrenergic clonal line functional cellular receptor multipotential neural precursors lipid phosphoric acids orphan receptor geneedg-1 related expression data structurally-related molecule related subjects presumptive cortical neuroblasts cerebral cortex platelet activating factor functional clonal lines programmed cell death sphingosine 1-phosphate singalling postnatal murine brain

Questions {❓}

(1982) Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators?

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         headline:A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs)
         description:A missing component in the experimental analysis of cell signaling by extracellular lysophospholipids such as lysophosphatidic acid (LPA) or sphingosine-1-phosphate (S1P) has been cloned receptors. Through studies on the developing brain, the first such receptor gene (referred to asvzg-1) was identified, representing a member of the G-protein coupled receptor (GPCR) super family(1). Here we review the neurobiological approach that led to both its cloning and identification as a receptor for LPA, along with related expression data. Summarized sequence and genomic structure analyses indicate that this first, functionally identified receptor is encoded by a member of a growing gene family that divides into at least two subgroups: genes most homologous to the high-affinity LPA receptor encoded byvzg-1, and those more homologous to an orphan receptor geneedg-1 that has recently been identified as a S1P receptor. A provisional nomenclature is proposed, based on published functional ligand actions, amino acid composition and genomic structure whereby the receptors encoded by these genes are referred to as lysophospholipid (LP) receptors, with subgroups distinguished by letter and number subscripts (e.g., LPA1 for Vzg-1, and LPB1 for Edg-1). Presented expression data support the recently published work indicating that members of the LPB1 subgroup are receptors for the structurally-related molecule, S1P. The availability of cloned LP receptors will enhance the analysis of the many documented LP effects, while their prominent expression in the nervous system indicates significant but as yet unknown roles in development, normal function, and neuropathology.
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            LPA, sphinosine-1-phosphate, S1P
            cannabanoid
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      headline:A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs)
      description:A missing component in the experimental analysis of cell signaling by extracellular lysophospholipids such as lysophosphatidic acid (LPA) or sphingosine-1-phosphate (S1P) has been cloned receptors. Through studies on the developing brain, the first such receptor gene (referred to asvzg-1) was identified, representing a member of the G-protein coupled receptor (GPCR) super family(1). Here we review the neurobiological approach that led to both its cloning and identification as a receptor for LPA, along with related expression data. Summarized sequence and genomic structure analyses indicate that this first, functionally identified receptor is encoded by a member of a growing gene family that divides into at least two subgroups: genes most homologous to the high-affinity LPA receptor encoded byvzg-1, and those more homologous to an orphan receptor geneedg-1 that has recently been identified as a S1P receptor. A provisional nomenclature is proposed, based on published functional ligand actions, amino acid composition and genomic structure whereby the receptors encoded by these genes are referred to as lysophospholipid (LP) receptors, with subgroups distinguished by letter and number subscripts (e.g., LPA1 for Vzg-1, and LPB1 for Edg-1). Presented expression data support the recently published work indicating that members of the LPB1 subgroup are receptors for the structurally-related molecule, S1P. The availability of cloned LP receptors will enhance the analysis of the many documented LP effects, while their prominent expression in the nervous system indicates significant but as yet unknown roles in development, normal function, and neuropathology.
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      dateModified:
      pageStart:213
      pageEnd:242
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         Lysophosphatidic acid
         LPA, sphinosine-1-phosphate, S1P
         cannabanoid
         G-protein coupled receptor
         CNS development
         Cerebral cortex
         Biochemistry
         general
         Pharmacology/Toxicology
         Biotechnology
         Cell Biology
         Biological and Medical Physics
         Biophysics
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