We are analyzing https://link.springer.com/article/10.1007/bf02110643.

Title:
The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal | Journal of Bioenergetics and Biomembranes
Description:
Mitochondria from a variety of sources possess an inner membrane channel, the permeability transition pore. The pore is a voltage-dependent channel, activated by matrix Ca2+ and inhibited by matrix H+, which can be blocked by cyclosporin A, presumably after binding to mitochondrial cyclophilin. The physiological function of the permeability transition pore remains unknown. Here we evaluate its potential role as a fast Ca2+ release channel involved in mitochondrial and cellular Ca2+ homeostasis. We (i) discuss the theoretical and experimental reasons why mitochondria need a fast, inducible Ca2+ release channel; (ii) analyze the striking analogies between the mitochondrial permeability transition pore and the sarcoplasmic reticulum ryanodine receptor-Ca2+ release channel; (iii) argue that the permeability transition pore can act as a selective release channel for Ca2+ despite its apparent lack of selectivity for the transported speciesin vitro; and (iv) discuss the importance of mitochondria in cellular Ca2+ homeostasis, and how disruption of this function could impinge upon cell viability, particularly under conditions of oxidative stress.
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Keywords {🔍}

google, scholar, pubmed, article, biol, chem, bernardi, petronilli, pore, mitochondrial, permeability, transition, bioenerg, biomembr, channel, biochem, calcium, release, cell, channels, lett, szabó, zoratti, biophys, physiol, privacy, cookies, content, journal, access, febs, colonna, pfeiffer, nature, publish, search, acta, function, data, information, log, research, biomembranes, valeria, mitochondria, membrane, discover, pozzan, broekemeier, marks,

Topics {✒️}

month download article/chapter permeability transition pore related subjects selective release channel cell calcium 15 privacy choices/manage cookies full article pdf voltage-dependent channel cellular ca2+ homeostasis mitochondrial ca2+ european economic area transported speciesin vitro check access instant access accepting optional cookies critical appraisal published april 1996 volume 28 mitochondrial cyclophilin mitochondrial membrane journal finder publish article bernardi conditions privacy policy main content log article journal article log biomembranes article article cite membrane channel cyclosporin mitochondrial privacy policy personal data books a pore optional cookies manage preferences critical appraisal matrix ca2+ journal publish data protection essential cookies cookies skip subscription content similar content institution subscribe petronilli cell viability usage analysis social media varying standards

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         description:Mitochondria from a variety of sources possess an inner membrane channel, the permeability transition pore. The pore is a voltage-dependent channel, activated by matrix Ca2+ and inhibited by matrix H+, which can be blocked by cyclosporin A, presumably after binding to mitochondrial cyclophilin. The physiological function of the permeability transition pore remains unknown. Here we evaluate its potential role as a fast Ca2+ release channel involved in mitochondrial and cellular Ca2+ homeostasis. We (i) discuss the theoretical and experimental reasons why mitochondria need a fast, inducible Ca2+ release channel; (ii) analyze the striking analogies between the mitochondrial permeability transition pore and the sarcoplasmic reticulum ryanodine receptor-Ca2+ release channel; (iii) argue that the permeability transition pore can act as a selective release channel for Ca2+ despite its apparent lack of selectivity for the transported speciesin vitro; and (iv) discuss the importance of mitochondria in cellular Ca2+ homeostasis, and how disruption of this function could impinge upon cell viability, particularly under conditions of oxidative stress.
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            calcium channels
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            ryanodine receptor
            Bioorganic Chemistry
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            Animal Biochemistry
            Organic Chemistry
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      headline:The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal
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         permeability transition pore
         calcium channels
         cyclosporin A
         ryanodine receptor
         Bioorganic Chemistry
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         Animal Anatomy / Morphology / Histology
         Animal Biochemistry
         Organic Chemistry
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