We are analyzing https://link.springer.com/article/10.1007/bf02102807.

Title:
The structure of human mitochondrial DNA variation | Journal of Molecular Evolution
Description:
Restriction analysis of mitochondrial DNA (mtDNA) of 3065 humans from 62 geographic samples identified 149 haplotypes and 81 polymorphic sites. These data were used to test several aspects of the evolutionary past of the human species. A dendrogram depicting the genetic relatedness of all haplotypes shows that the native African populations have the greatest diversity and, consistent with evidence from a variety of sources, suggests an African origin for our species. The data also indicate that two individuals drawn, at random from the entire sample will differ at approximately 0.4% of their mtDNA nucleotide sites, which is somewhat higher than previous estimates. Human mtDNA also exhibits more interpopulation heterogeneity (GST=0.351±0.025) than does nuclear DNA (GST=0.12). Moreover, the virtual absence of intermediate levels of linkage disequilibrium between pairs of sites is consistent with the absence of genetic recombination and places constraints on the rate of mutation. Tests of the selective neutrality of mtDNA variation, including the Ewens-Watterson and Tajima tests, indicate a departure in the direction consistent with purifying selection, but this departure is more likely due to the rapid growth of the human population and the geographic heterogeneity of the variation. The lack of a good fit to neutrality poses problems for the estimation of times of coalescence from human mtDNA data.
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Keywords {🔍}

google, scholar, mitochondrial, dna, pubmed, human, hum, genet, genetics, populations, population, wallace, genetic, usa, data, article, restriction, polymorphism, variation, analysis, evolution, mol, evol, molecular, nei, polymorphisms, proc, natl, acad, sci, university, research, schurr, evolutionary, torroni, santachiara, benerecetti, italy, ann, wilson, privacy, cookies, content, journal, clark, ballinger, mtdna, african, nucleotide, tajima,

Topics {✒️}

month download article/chapter human mitochondrial genome amerindian mitochondrial dnas human mitochondrial dna privacy choices/manage cookies mitochondrial dna types full article pdf mitochondrial dna lineages mitochondrial dna polymorphisms rollins research center south african institute mitochondrial dna polymorphism mitochondrial dna mutation himla soodyall trefor jenkins mitochondrial dna sequences studying genetic variation restriction endonuclease analysis animal mitochondrial dna common mitochondrial mother molecular evolution aims estimating genetic divergence restriction endonuclease polymorphisms genetic data analysis pennsylvania state university european economic area scope submit manuscript investigating mitonuclear interactions related subjects ancient mongoloid migrations cavalli-sforza ll major noncoding region base pair recognition cavalli-svorza ll interpopulational genetic diversity constructing phylogenetic trees dramatic founder effects hereditary optic neuropathy exponentially growing populations maternal african ancestry rare asian mutations native african populations conditions privacy policy selectively neutral alleles human mtdna data astaldi ricotti gb highly polymorphic rflps low nucleotide diversity neutral mutation hypothesis high frequencies suggesting

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         description:Restriction analysis of mitochondrial DNA (mtDNA) of 3065 humans from 62 geographic samples identified 149 haplotypes and 81 polymorphic sites. These data were used to test several aspects of the evolutionary past of the human species. A dendrogram depicting the genetic relatedness of all haplotypes shows that the native African populations have the greatest diversity and, consistent with evidence from a variety of sources, suggests an African origin for our species. The data also indicate that two individuals drawn, at random from the entire sample will differ at approximately 0.4% of their mtDNA nucleotide sites, which is somewhat higher than previous estimates. Human mtDNA also exhibits more interpopulation heterogeneity (GST=0.351±0.025) than does nuclear DNA (GST=0.12). Moreover, the virtual absence of intermediate levels of linkage disequilibrium between pairs of sites is consistent with the absence of genetic recombination and places constraints on the rate of mutation. Tests of the selective neutrality of mtDNA variation, including the Ewens-Watterson and Tajima tests, indicate a departure in the direction consistent with purifying selection, but this departure is more likely due to the rapid growth of the human population and the geographic heterogeneity of the variation. The lack of a good fit to neutrality poses problems for the estimation of times of coalescence from human mtDNA data.
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         Animal Genetics and Genomics
         Cell Biology
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