We are analyzing https://link.springer.com/article/10.1007/bf01812682.

Title:
Hormone dependence of a mouse mammary tumor line inducedin vivo by medroxyprogesterone acetate | Breast Cancer Research and Treatment
Description:
The administration of MPA to virgin female BALB/c mice led to the development of mammary adenocarcinomas, which in furtherin vivo transplants gave rise to both MPA-dependent and MPA-independent lines. In this paper we chose one of the MPA-dependent lines with high contents of estrogen (ER) and progesterone (PR) receptors, and were able to demonstrate that a) the growth of these tumors could be manipulated by the administration or the withdrawal of the hormonal supply;b) PR were down-regulated in MPA-treated mice; c) progesterone had the same stimulatory effect as MPA on tumor growth; d) tumors did not grow in estrogen-treated mice; e) tumor growth was much lower in males than in females; f) the presence of the ovaries had a positive influence on tumor growth, even in the presence of MPA; g) the withdrawal of progestin pellets in ovariectomized mice usually led to complete remissions followed by regrowth of the tumors after several weeks; and h) the regrowing tumors maintained their steroid receptor pattern and (in 3 out of 4 cases) their hormone-dependent behavior in further passages.
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Keywords {🔍}

google, scholar, cancer, mammary, medroxyprogesterone, pubmed, acetate, tumors, breast, growth, mouse, mice, eds, hormone, tumor, progesterone, article, lanari, role, endocrinerelated, raven, press, york, res, dosne, pasqualini, receptors, robustelli, della, cuna, charreau, mpa, natl, privacy, cookies, content, research, treatment, kordon, effect, taylor, carcinoma, molinolo, inst, cell, publish, search, vivo, administration, adenocarcinomas,

Topics {✒️}

dmba-induced mammary tumors balb/cin vivo sublines month download article/chapter androgen-hypersensitive cell clones mammary adenocarcinomas induced royer de giaroli mouse mammary tumorigenesis hormone-dependent behavior mouse mammary tumors mammary shionogi carcinoma murine mammary tumorigenesis nude mouse model privacy choices/manage cookies rat mammary gland fathy el etreby hormone responsive growth advanced breast cancer hormone dependence transplantable mammary cancers human breast carcinoma robustelli della cuna anti-tumor activity mpa-dependent lines experimental antitumor activity foreign body tumorigenesis functional steroid receptors full article pdf mammary adenocarcinomas progesterone receptor levels advanced cancer patients regrowing tumors maintained endocrine-related tumors hormonal receptors mpa-independent lines depot medroxyprogesterone acetate european economic area hypothalamic-pituitary systems receptores para esteroides le goff jm multiple dose administration conditions privacy policy mpa-treated mice specific estrogen binding estrogen receptor content human endometrial carcinoma steroid receptor pattern heuson-stennon ja mammary gland coffey rj jr estrogen-treated mice

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         description:The administration of MPA to virgin female BALB/c mice led to the development of mammary adenocarcinomas, which in furtherin vivo transplants gave rise to both MPA-dependent and MPA-independent lines. In this paper we chose one of the MPA-dependent lines with high contents of estrogen (ER) and progesterone (PR) receptors, and were able to demonstrate that a) the growth of these tumors could be manipulated by the administration or the withdrawal of the hormonal supply;b) PR were down-regulated in MPA-treated mice; c) progesterone had the same stimulatory effect as MPA on tumor growth; d) tumors did not grow in estrogen-treated mice; e) tumor growth was much lower in males than in females; f) the presence of the ovaries had a positive influence on tumor growth, even in the presence of MPA; g) the withdrawal of progestin pellets in ovariectomized mice usually led to complete remissions followed by regrowth of the tumors after several weeks; and h) the regrowing tumors maintained their steroid receptor pattern and (in 3 out of 4 cases) their hormone-dependent behavior in further passages.
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      headline:Hormone dependence of a mouse mammary tumor line inducedin vivo by medroxyprogesterone acetate
      description:The administration of MPA to virgin female BALB/c mice led to the development of mammary adenocarcinomas, which in furtherin vivo transplants gave rise to both MPA-dependent and MPA-independent lines. In this paper we chose one of the MPA-dependent lines with high contents of estrogen (ER) and progesterone (PR) receptors, and were able to demonstrate that a) the growth of these tumors could be manipulated by the administration or the withdrawal of the hormonal supply;b) PR were down-regulated in MPA-treated mice; c) progesterone had the same stimulatory effect as MPA on tumor growth; d) tumors did not grow in estrogen-treated mice; e) tumor growth was much lower in males than in females; f) the presence of the ovaries had a positive influence on tumor growth, even in the presence of MPA; g) the withdrawal of progestin pellets in ovariectomized mice usually led to complete remissions followed by regrowth of the tumors after several weeks; and h) the regrowing tumors maintained their steroid receptor pattern and (in 3 out of 4 cases) their hormone-dependent behavior in further passages.
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