We are analyzing https://link.springer.com/article/10.1007/bf01805760.

Title:
Endocrine therapy of human breast cancer grown in nude mice | Breast Cancer Research and Treatment
Description:
Although there have been extensive studies of rodent breast tumor models, and of human breast cancer cell lines in culture, there is still need for a human tumor model which can be manipulated experimentally but also provides a valid expression of the tumor cells in a host environment. Athymic nude mice bearing transplanted human breast tumors have been proposed as such a model. This review therefore discusses the use of the athymic nude mouse model of the study of human breast cancer biology, and focuses on four subjects: 1. biological characteristics of heterotransplanted breast tumors; 2. endocrinology and pharmacology of hormonal agents in the nude mouse; 3. endocrine sensitivity of heterotransplanted tumors; and 4. applicability and limitations of this model for the study of human breast cancer.
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Keywords {🔍}

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Topics {✒️}

human breast-cancer xenografts month download article/chapter receptor-positive t61 hormone-dependent mammary tumors long-term antiestrogen therapy human breast carcinomas human breast carcinoma long-term serial transplantation human breast cancer testing endocrine treatment human malignant tumor human mammary carcinoma long-term tissue culture human tumor xenografts human tumor cells endocrine therapy studies experimental endocrine therapy direct growth-stimulating effect endocrine ablated balb/ privacy choices/manage cookies human cell line human malignant tumors cell cycle kinetics flow microflurometric analysis human tumor model steroid receptor profile full article pdf heterotransplanted breast tumors pleural effusion derived cancer clin oncol plasma hormone levels cell cycle distribution murine mammary tumorigenesis neoplastic mammary tissues athymic nude mice anin vivo manifestation endocrine therapy athymic ‘nude’ mouse athymic nude mouse breast carcinomas breast carcinoma european economic area charles brenton huggins comparative functional histopathology immune-deficient animals immune deficient animals s-phase fractions hypothalamo-pituitaryovarian axis diminished gonadotropin concentrations nu/nu-balb/

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