We are analyzing https://link.springer.com/article/10.1007/bf01703109.

Title:
The evaluation of low-dose cytarabine in the treatment of myelodysplastic syndromes: A phase-III intergroup study | Annals of Hematology
Description:
One hundred and forty one patients were treated in a combined Eastern Cooperative Oncology Group and Southwest Oncology Group phase-III study evaluating low-dose cytarabine (LDAC) versus supportive therapy for the treatment of myelodysplastic syndrome (MDS). Patients were randomized to either cytarabine 10 mg/m2 subcutaneously BID or supportive therapy. Central pathology review was required. All patients were classified according to the FAB criteria for MDS. The overall concordance rate for the MDS subtype was 52%, and 25 patients were pathology exclusions, including 20 with AML. The overall response rate to a single cycle of LDAC was 32%, with 11% complete and 21% partial responses. The median duration of response was 5.9 months, with a range of 1.4–33.5 months. Responses were seen in all subtypes. Infections were more common in the LDAC arm. There was no difference in the time to progression or the overall survival for patients treated with LDAC or supportive therapy. The incidence of leukemic transformation was similar in both arms at 15%, but it differed according to the MDS subtype. Patients receiving LDAC had a decreased transfusion requirement after 3 months. There was a significant correlation between the degree of cytoreduction after receiving a single cycle of LDAC and survival. This survival difference was most marked in patients with the RAEB and RAEB-T subtypes. Although LDAC produced responses in all subtypes of the MDS, there was no effect on overall survival or transformation to AML. However, selected patients benefited from a single cycle of LDAC with durable responses. A cytoreductive effect appears to be required for a durable response. Future studies should include pathology review and must address the clinical and biological heterogeneity of MDS.
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Topics {✒️}

french-american-british cooperative group phase-iii intergroup study high-dose cytosine arabinoside month download article/chapter low-dose cytosine arabinoside chronic myelodysplastic syndrome acute myeloid leukemia southwestern oncology group low-dose cytarabine low dose cytarabine recombinant human interleukin-3 chronic myelodysplastic syndromes related subjects leukemia intergroup study childrens research hospital privacy choices/manage cookies mississippi medical center full article pdf hematology article pennsylvania cancer center myelodysplastic syndrome european economic area scope submit manuscript decreased transfusion requirement bone marrow transplantation proposed revised criteris 13-cis retinoic acid generalized linear models long-term analysis refined chromosome analysis check access instant access /ii study conditions privacy policy central pathology review include pathology review myelodys-plastic disorders rochester cancer center longitudinal data analysis independent prognostic indicator accepting optional cookies article annals hematology aims cytoreductive effect appears dysmyelopoietic syndrome acute leukemia selected patients benefited versus supportive therapy journal finder publish article miller

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