We are analyzing https://link.springer.com/article/10.1007/bf01209485.

Title:
Establishment and characterization of a new human oestradiol- and progesterone-receptor-positive mammary carcinoma serially transplantable in nude mice | Journal of Cancer Research and Clinical Oncology
Description:
A human mammary carcinoma originating from a postmenopausal patient was successfully transplanted into nude mice. According to the adopted criteria the tumour proved to be oestradiol- and progesterone-receptor-positive. Histological studies of the patient tumour revealed a ductal invasive mammary carcinoma with 80% tubular growth pattern. Following transplantation the adenoid structures decreased to 30%; the mitosis rate and grade of malignancy increased. Treatment of the nude mice with 20 μg oestradiol benzoate/mouse caused a loss of the oestradiol receptor of the mammary carcinoma. The mammary carcinoma 3366 can be used for testing of antineoplastic substances, antihormones and for studies in regard to down-regulation or blocking of hormone receptors and possible consequences for therapies.
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Keywords {🔍}

cancer, breast, article, mammary, google, scholar, human, carcinoma, mice, nude, pubmed, oestradiol, access, privacy, cookies, content, journal, research, growth, information, publish, search, naundorf, receptors, data, standards, log, oncology, establishment, characterization, progesteronereceptorpositive, fichtner, büttner, receptor, hormone, expression, open, discover, eur, clin, oncol, lippman, mol, endocrinol, download, springer, optional, analysis, personal, parties,

Topics {✒️}

growth factor-i-related protein progesterone-receptor-positive month download article/chapter transforming growth factor-alpha human breast cancer breast cancer tissue breast cancer change related subjects privacy choices/manage cookies oestrogen receptor concentration clinical oncology aims hormone receptors mammary carcinoma mammary carcinoma 3366 full article pdf cancer research european economic area adenoid structures decreased estrogen receptors improved conventional conditions robert-rössle-str conditions privacy policy january 1992 volume 119 oestradiol receptor accepting optional cookies patient tumour revealed check access instant access mammary epithelium journal finder publish nude mice main content log article naundorf human oestradiol article journal growth factor article log privacy policy personal data article cite books a büttner cancer 9 cancer 16 cancer 61 optional cookies manage preferences berlin-buch journal publish establishment

Questions {❓}

Hawkins RA, Tesdale AL, Anderson EDC, Levack PA, Chetty U, Forrest APM (1990) Does the oestrogen receptor concentration of a breast cancer change during systemic therapy?

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