We are analyzing https://link.springer.com/article/10.1007/bf00571507.

Title:
The proximal peripheral nervous system is a major site of demyelination in experimental autoimmune encephalomyelitis induced in the Lewis rat by a myelin basic protein-specific T cell clone | Acta Neuropathologica
Description:
Experimental autoimmune encephalomyelitis (EAE) was induced in the Lewis rat by the passive transfer of a cytotoxic CD4+ T cell clone specific for the 72–89 peptide of guinea-pig myelin basic protein (MBP). Histological studies on rats with neurological signs showed that inflammation was present in the proximal peripheral nervous system (PNS), namely the spinal roots, as well as in the central nervous system (CNS). The main sites of demyelination were the spinal roots in the PNS, and the spinal cord root entry and exit zones in the CNS. The major involvement of the proximal PNS in autoimmune disease directed at MBP is in marked contrast to EAE induced by immunisation with myelin proteolipid protein, where the inflammation and demyelination are restricted to the CNS. These findings may have implications for the human inflammatory demyelinating diseases including multiple sclerosis, in which MBP is a putative target antigen.
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Keywords {🔍}

google, scholar, encephalomyelitis, experimental, myelin, pender, nervous, system, autoimmune, basic, article, peripheral, protein, demyelination, lewis, rat, multiple, sclerosis, induced, cell, allergic, nguyen, mccombe, access, privacy, cookies, content, central, nerve, neurol, sci, publish, research, search, acta, proximal, clone, tabi, eae, spinal, cells, site, data, information, log, journal, major, mbp, rats, pns,

Topics {✒️}

month download article/chapter myelin basic protein-specific experimental autoimmune encephalomyelitis experimental allergic encephalomyelitis myelin basic protein cell clone access peripheral nervous system myelin proteolipid protein multiple sclerosis cell clone specific central nervous system peripheral nerve excitability privacy choices/manage cookies related subjects autoimmune disease directed full article pdf peripheral nerve abnormalities schwann cells basic protein european economic area november 1995 volume 89 putative target antigen tumour necrosis factor glycol methacrylate sections royal brisbane hospital secondary encephalitogenic epitope conditions privacy policy cell clone neurological signs showed nervous system proteolipid protein accepting optional cookies clinical sciences building repair journal finder publish check access instant access article pender main content log immune-mediated demyelination myelin biology p1 protein protein composition article log mccombe rights waxman sg pender mp article cite acta neuropathol acta neuropathol 89

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