We are analyzing https://link.springer.com/article/10.1007/bf00403185.

Title:
An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1β | Diabetologia
Description:
The cytokine interleukin-1β may have an important role in the autoimmune mediated damage of pancreatic Beta cells in insulin-dependent diabetes mellitus. In the present study we have investigated the effects of an interleukin-1 receptor antagonist protein, a blocker of the type I interleukin-1 receptor, on the suppressive actions of recombinant interleukin-1β on insulin-producing cells. Brief exposure (1–2 h) of rat and mouse pancreatic islets to 10 ng/ml recombinant interleukin-1β induced an 70–80% inhibition of insulin response to glucose after 12 h. These effects were completely counteracted by co-incubation with 100 ng/ml interleukin-1 receptor antagonist protein. When rat islets were cultured for 48 h in the presence of recombinant interleukin-1β (5 ng/ml) higher concentrations of interleukin-1 receptor antagonist protein (5000 ng/ml) were required to protect Beta-cell function. Interleukin-1 receptor antagonist protein also counteracted the inhibitory effects of recombinant interleukin-1β on the growth of the rat insulinoma cell line RINm5F. These data suggest that interleukin-1 receptor antagonist protein can protect insulin-producing cells from the deleterious effects of recombinant interleukin-1β, and that these cells possess type I interleukin-1 receptors.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Topics {✒️}

insulin-dependent diabetes mellitus protect insulin-producing cells insulin-producing cells cells possess type pancreatic beta cells protect beta-cell function recombinant interleukin-1β mouse pancreatic islets rat pancreatic islets interleukin-1β induces cytokine interleukin-1β human interleukin 1β privacy choices/manage cookies β-cell function interleukin-1 receptor insulin response pancreatic islets interleukin-1β interleukin-1 receptors decreased cell replication medical cell biology european economic area autoimmune mediated damage related subjects fahey iii tj main content log conditions privacy policy host inflammatory response medical department tta accepting optional cookies scope submit manuscript rat islets requires gene transcription 5 ng/ml 5000 ng/ml article eizirik journal finder publish type bendtzen rights search search eizirik dl protein synthesis article cite nielsen jh privacy policy mcdaniel ml personal data books a interleukin 1 optional cookies

Schema {🗺️}

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         headline:An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1β
         description:The cytokine interleukin-1β may have an important role in the autoimmune mediated damage of pancreatic Beta cells in insulin-dependent diabetes mellitus. In the present study we have investigated the effects of an interleukin-1 receptor antagonist protein, a blocker of the type I interleukin-1 receptor, on the suppressive actions of recombinant interleukin-1β on insulin-producing cells. Brief exposure (1–2 h) of rat and mouse pancreatic islets to 10 ng/ml recombinant interleukin-1β induced an 70–80% inhibition of insulin response to glucose after 12 h. These effects were completely counteracted by co-incubation with 100 ng/ml interleukin-1 receptor antagonist protein. When rat islets were cultured for 48 h in the presence of recombinant interleukin-1β (5 ng/ml) higher concentrations of interleukin-1 receptor antagonist protein (5000 ng/ml) were required to protect Beta-cell function. Interleukin-1 receptor antagonist protein also counteracted the inhibitory effects of recombinant interleukin-1β on the growth of the rat insulinoma cell line RINm5F. These data suggest that interleukin-1 receptor antagonist protein can protect insulin-producing cells from the deleterious effects of recombinant interleukin-1β, and that these cells possess type I interleukin-1 receptors.
         datePublished:
         dateModified:
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            Human Physiology
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ScholarlyArticle:
      headline:An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1β
      description:The cytokine interleukin-1β may have an important role in the autoimmune mediated damage of pancreatic Beta cells in insulin-dependent diabetes mellitus. In the present study we have investigated the effects of an interleukin-1 receptor antagonist protein, a blocker of the type I interleukin-1 receptor, on the suppressive actions of recombinant interleukin-1β on insulin-producing cells. Brief exposure (1–2 h) of rat and mouse pancreatic islets to 10 ng/ml recombinant interleukin-1β induced an 70–80% inhibition of insulin response to glucose after 12 h. These effects were completely counteracted by co-incubation with 100 ng/ml interleukin-1 receptor antagonist protein. When rat islets were cultured for 48 h in the presence of recombinant interleukin-1β (5 ng/ml) higher concentrations of interleukin-1 receptor antagonist protein (5000 ng/ml) were required to protect Beta-cell function. Interleukin-1 receptor antagonist protein also counteracted the inhibitory effects of recombinant interleukin-1β on the growth of the rat insulinoma cell line RINm5F. These data suggest that interleukin-1 receptor antagonist protein can protect insulin-producing cells from the deleterious effects of recombinant interleukin-1β, and that these cells possess type I interleukin-1 receptors.
      datePublished:
      dateModified:
      pageStart:445
      pageEnd:448
      sameAs:https://doi.org/10.1007/BF00403185
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         Interleukin-1β
         interleukin 1 receptor
         insulin secretion
         pancreatic islets
         RINm5F cells
         insulin-dependent diabetes mellitus
         Internal Medicine
         Metabolic Diseases
         Human Physiology
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      name:Laboratory of Medical Immunology, Medical Department TTA, University Hospital, Copenhagen, Denmark
      name:Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

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