We are analyzing https://link.springer.com/article/10.1007/bf00378090.

Title:
Increase in the amount of erythrocyte δ-aminolevulinic acid dehydratase in workers with moderate lead exposure | International Archives of Occupational and Environmental Health
Description:
The amount of ALA-D in human erythrocytes was determined directly by radioimmunoassay or calculated from the restored activity assayed in the presence of zinc and dithiothreitol, and a good correlation was observed between the RIA-based and the restored activity-based amounts. The RIA-based amount of ALA-D in the blood of 10 normal individuals (blood lead levels of 5.6 ± 2.3 μg/100 ml: mean ± SD) and 19 lead-exposed workers (blood lead levels of 41.2 ± 10.2 μg/100 ml) was 54.1 ± 11.8 μg/ml blood and 92.3 ± 20.6 μg/ml blood, respectively, indicating an apparent increase of the enzyme amount in lead-exposed workers. A significant increase in the amount of erythrocyte ALA-D calculated from the restored activity in lead-exposed workers was observed even in the low blood lead level of 10–20 μg/100 ml, resulting in the range of blood lead level 20–40 μg/100 ml. No significant difference was observed in hematocrit and hemoglobin content between lead-exposed and non-exposed groups. These observations suggested that the increase of erythrocyte ALA-D in lead exposure was not due to anemia, which might result in the increase of young erythrocytes in peripheral blood. This increase in the amount of ALA-D in human erythrocytes might be a result of the function to overcome the inhibition of the enzyme in bone marrow cells during lead exposure, and these findings may throw light on the danger to human health of low-level lead toxicity.
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Keywords {🔍}

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Topics {✒️}

determining delta-aminolevulinic dehydratase month download article/chapter δ-aminolevulinic acid dehydratase urinary δ-aminolevulinic acid 5-amnoevulinic acid hydro-lyase low-level lead toxicity restored activity-based amounts 5-aminolevulinic acid dehydratase δ-aminolevulinic acid article international archives related subjects privacy choices/manage cookies environmental health aims moderate lead exposure full article pdf s-aminolevulinate dehydratase high specific activity erythrocyte osmotic fragility erythrocyte porphobilinogen synthase science research fund restored activity assayed european economic area bone marrow cells folin phenol regent blood lead level conditions privacy policy tohoku university school inherited disease essential thiol group european standardized method article fujita 8 μg/ml blood 6 μg/ml blood radioimmunoassay restored activity blood lead levels accepting optional cookies ria-based amount journal finder publish leadintoxicated rats 19 lead-exposed workers lead-exposed workers environmental health 6-aminolevulinate dehydratase human health research grant ind health 22 public health restored activity restored activity environ res 1

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         description:The amount of ALA-D in human erythrocytes was determined directly by radioimmunoassay or calculated from the restored activity assayed in the presence of zinc and dithiothreitol, and a good correlation was observed between the RIA-based and the restored activity-based amounts. The RIA-based amount of ALA-D in the blood of 10 normal individuals (blood lead levels of 5.6 ± 2.3 μg/100 ml: mean ± SD) and 19 lead-exposed workers (blood lead levels of 41.2 ± 10.2 μg/100 ml) was 54.1 ± 11.8 μg/ml blood and 92.3 ± 20.6 μg/ml blood, respectively, indicating an apparent increase of the enzyme amount in lead-exposed workers. A significant increase in the amount of erythrocyte ALA-D calculated from the restored activity in lead-exposed workers was observed even in the low blood lead level of 10–20 μg/100 ml, resulting in the range of blood lead level 20–40 μg/100 ml. No significant difference was observed in hematocrit and hemoglobin content between lead-exposed and non-exposed groups. These observations suggested that the increase of erythrocyte ALA-D in lead exposure was not due to anemia, which might result in the increase of young erythrocytes in peripheral blood. This increase in the amount of ALA-D in human erythrocytes might be a result of the function to overcome the inhibition of the enzyme in bone marrow cells during lead exposure, and these findings may throw light on the danger to human health of low-level lead toxicity.
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      headline:Increase in the amount of erythrocyte δ-aminolevulinic acid dehydratase in workers with moderate lead exposure
      description:The amount of ALA-D in human erythrocytes was determined directly by radioimmunoassay or calculated from the restored activity assayed in the presence of zinc and dithiothreitol, and a good correlation was observed between the RIA-based and the restored activity-based amounts. The RIA-based amount of ALA-D in the blood of 10 normal individuals (blood lead levels of 5.6 ± 2.3 μg/100 ml: mean ± SD) and 19 lead-exposed workers (blood lead levels of 41.2 ± 10.2 μg/100 ml) was 54.1 ± 11.8 μg/ml blood and 92.3 ± 20.6 μg/ml blood, respectively, indicating an apparent increase of the enzyme amount in lead-exposed workers. A significant increase in the amount of erythrocyte ALA-D calculated from the restored activity in lead-exposed workers was observed even in the low blood lead level of 10–20 μg/100 ml, resulting in the range of blood lead level 20–40 μg/100 ml. No significant difference was observed in hematocrit and hemoglobin content between lead-exposed and non-exposed groups. These observations suggested that the increase of erythrocyte ALA-D in lead exposure was not due to anemia, which might result in the increase of young erythrocytes in peripheral blood. This increase in the amount of ALA-D in human erythrocytes might be a result of the function to overcome the inhibition of the enzyme in bone marrow cells during lead exposure, and these findings may throw light on the danger to human health of low-level lead toxicity.
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         Radioimmunoassay
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         Environmental Health
         Rehabilitation
         Occupational Medicine/Industrial Medicine
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