We are analyzing https://link.springer.com/article/10.1007/bf00334886.

Title:
Synaptic stripping in the human facial nucleus | Acta Neuropathologica
Description:
An autopsy case of severe peripheral facial nerve paresis with disconnection of synapses from facial motor neurons is reported. A 77-year-old man presented with left-sided otitis media and subsequent development of facial nerve paresis. Three months later, the patient died of an acute gastrointestinal bleeding from a chronic duodenal ulcer. Gross inspection of the brain revealed non-stenosing arteriosclerotic vascular changes and a single small cystic lesion in the right putamen. Microscopically, marked chromatolytic changes were observed in the left facial nucleus. Immunocytochemistry for synaptophysin revealed a marked loss of afferent synaptic contacts from somatic and stem dendritic surface membranes of all chromatolytic motor neurons. Wrapping of a number of neurons by newly formed glial fibrillary acidic protein-positive astrocytic cell processes could be detected in the regenerting facial motor nucleus. In addition, expression of HLA-DR was increased on a small number of microglia and pertivascular cells. These changes were absent from the contralateral, normal-appearing facial nucleus. To our knowledge, this case provides the first evidence for disconnection of synapses following peripheral nerve lesioning in humans. Occurrence of synaptic stripping is likely to explain nuclear hyperexcitability and failure of recovery of complex fine motor movements that are commonly observed following peripheral injury to the facial nerve.
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Keywords {🔍}

facial, google, scholar, kreutzberg, graeber, synaptic, nerve, nucleus, motor, article, regeneration, neurol, privacy, cookies, glial, content, publish, research, search, peripheral, neurons, microglia, cells, injury, access, motoneurons, york, astrocytes, neuron, streit, neuropathology, data, information, log, journal, acta, stripping, human, bise, mehraein, synapses, brain, fibrillary, acidic, discover, reaction, axotomy, download, springer, function,

Topics {✒️}

month download article/chapter left-sided otitis media afferent synaptic contacts altered synaptic organization normal-appearing facial nucleus perineuronal glial reactions neural regeneration research motor neuron axotomy synaptic stripping privacy choices/manage cookies astrocyte-neuron interactions human facial nucleus functional plasticity full article pdf facial motor neurons left facial nucleus facial nerve paresis synaptic terminals synaptic reorganization malignant external otitis major histocompatibility complex rat facial nucleus chromatolytic motor neurons facial nerve regeneration european economic area scope submit manuscript acute gastrointestinal bleeding chronic duodenal ulcer stenosing arteriosclerotic vascular xith international congress hemifacial spasm due ludwig maximilians university facial nerve palsy peripheral nerve lesioning conditions privacy policy explain nuclear hyperexcitability delayed astrocyte reaction facial nerve axotomy accepting optional cookies axotomized facial motoneurons main content log acta neuropathol 86 journal finder publish check access instant access glial response article graeber facial nucleus mehraein rights graeber mb

Questions {❓}

Martinelli P, Giuliani S, Ippoliti M (1992) Hemifacial spasm due to peripheral injury of facial nerve: a nuclear syndrome?

Schema {🗺️}

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