We are analyzing https://link.springer.com/article/10.1007/bf00300234.

Title:
Determination of subcutaneous tumor size in athymic (nude) mice | Cancer Chemotherapy and Pharmacology
Description:
The athymic (nude) mouse is a useful model for studying the biology and response to therapies of human tumors in vivo. A survey of recent literature revealed the use of 19 different formulas for determining the size of subcutaneous tumors grown as xenografts in nude mice (2 for determining tumor area, 3 for tumor diameter, and 14 for calculating tumor volume). We compared the volumes, areas, and diameters predicted by each of the 19 formulas with the actual weights of 50 tumors ranging from 0.46 to 22.0 g established in nude mice as xenografts from human cell lines. In addition to determining how well each formula predicted relative tumor size, we analyzed how well each formula estimated actual tumor mass. The ellipsoid volume formulas (π/6 x L x W x H and 1/2 x L x W x H) were best for estimating tumor mass (r=0.93), whereas measurements of diameter correlated poorly with tumor mass (r<0.66). Although determination of tumor area correlated well with tumor mass in small tumors (r=0.89), correlations of area with tumor mass for large tumors were poor (r=0.41). We conclude that determination of the ellipsoid volume from measurements of three axes consistently yields the most accurate estimations of both relative and actual tumor mass.
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Keywords {🔍}

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Topics {✒️}

syngeneic anti-tumour responses month download article/chapter tumor cell heterogeneity radiolabeled monoclonal antibody ovarian tumour xenografts human tumour xenografts monoclonal antibody treatment human cell lines invasive breast carcinomas september 1989 volume 24 squamous cell carcinoma human cancers grown calculating tumor volume privacy choices/manage cookies cell lines derived subcutaneous tumor size human neuroblastoma xenografted related subjects receptor-positive t61 tumour size human bronchial carcinomas human neural tumors human tumor xenografts full article pdf human cancer metastasis human melanoma serves bladder cancer xenografts wilms' tumor equine carcinoma cells human lactic dehydrogenase xenotransplantable human gastric glia maturation factor cell cycle distribution actual tumor mass human tumors xenografted spontaneous mammary carcinomas subcutaneous tumors grown dimensional tumor visualization mammary tumor virus complete tumor ablation human osteosarcoma xenografts human alpha-interferon human lymphoblastoid interferon mccombs wb iii human melanoma growth estimating tumor mass accurate estimations preclinical drug development acquired tumor resistance tumor area correlated

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            Accurate Estimation
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      headline:Determination of subcutaneous tumor size in athymic (nude) mice
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         Tumor Volume
         Nude Mouse
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         Accurate Estimation
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