We are analyzing https://link.springer.com/article/10.1007/bf00193951.

Title:
Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease | Virchows Archiv
Description:
Virchows Archiv - Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer
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Keywords {🔍}

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Topics {✒️}

month download article/chapter brain-type glucose transporter age-matched normal brains related subjects reduced glucose transporter microvessel endothelium cerebral microvessel ultrastructure full article pdf privacy choices/manage cookies decreased glucose availability diminished glucose transport glucose transporter normal hippocampal formation cerebral capillary bed blood-brain barrier hippocampal formation sections scanning electron microscope european economic area scope submit manuscript peptide-specific antibodies hospital medical school brain microvasculature defects recommended minimum data conditions privacy policy human erythrocyte membrane dynamic pet studies clinical diagnosis glut-1 immunolabelling senile plaque formation vascular basement membrane accepting optional cookies research studies check access disease access instant access journal finder publish article log vichows archiv davies rights august 1994 volume 425 acad sci 396 article cite article horwood pardridge wm senile dementia personal data privacy policy hippocampal pathology cerebral cortex davies dc

Schema {🗺️}

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         headline:Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease
         description:Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer's disease (AD). In order to investigate whether these changes are associated with compromised blood-brain transport mechanisms, hippocampal formation sections from AD and age-matched normal brains were immunolabelled with an antibody to the GLUT-1 glucose transporter protein. GLUT-1 immunolabelling of microvessel endothelium was significantly reduced in the AD compared to normal hippocampal formation. Thus, AD is associated with a reduction in cerebral microvessel endothelium glucose transporter content, which may result in decreased glucose availability to the brain.
         datePublished:
         dateModified:
         pageStart:69
         pageEnd:72
         sameAs:https://doi.org/10.1007/BF00193951
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            GLUT-1 Glucose transporter protein
            Immunohistochemistry
            Microvessel endothelium
            Hippocampus
            Alzheimer's disease
            Pathology
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      headline:Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease
      description:Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer's disease (AD). In order to investigate whether these changes are associated with compromised blood-brain transport mechanisms, hippocampal formation sections from AD and age-matched normal brains were immunolabelled with an antibody to the GLUT-1 glucose transporter protein. GLUT-1 immunolabelling of microvessel endothelium was significantly reduced in the AD compared to normal hippocampal formation. Thus, AD is associated with a reduction in cerebral microvessel endothelium glucose transporter content, which may result in decreased glucose availability to the brain.
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      dateModified:
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      pageEnd:72
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         Immunohistochemistry
         Microvessel endothelium
         Hippocampus
         Alzheimer's disease
         Pathology
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