We are analyzing https://link.springer.com/article/10.1007/bf00050795.

Title:
Basement membrane and the SIKVAV laminin-derived peptide promote tumor growth and metastases | Cancer and Metastasis Reviews
Description:
Laminin, the major glycoprotein component of basement membrane, promotes the malignant phenotype. Cells which are adherent to laminin are more malignant than the non-adherent cells and in certain tumor cells, the number of laminin receptors is positively correlated with malignancy. Laminin also increases collagenase IV activity, an enzyme demonstrated to be critical for tumor spread. A site on laminin, containing the amino acid sequence SIKVAV, has been identified which when injected intravenously with B16F10 melanoma cells, causes an increase in the number of colonies on the surface of the lungs. This peptide does not affect tumor cell arrest in the vasculature or the immune system. It does promote angiogenesis in various in vitro and in vivo models, thereby facilitating tumor cell survival. When a complex mixture of laminin-enriched basement membrane components (Matrigel) is coinjected with tumor cells subcutaneously, tumor incidence and growth increases. Various tumor cell lines and primary isolates, which previously could not form tumors in mice, can be induced to grow rapidly in the presence of Matrigel. Slowly growing tumors or arrested tumors can also be induced to grow more quickly with additional injections of Matrigel. When an SIKVAV-containing synthetic peptide is coinjected with B16F10 tumor cells and Matrigel subcutaneously in mice, larger tumors are formed than that observed with either Matrigel or cells alone. Such studies define the role of laminin in tumor growth and spread and generate new models for studying therapeutic agents. Of particular interest is the ability to grow primary isolates which generally do not grow in mice.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Telecommunications

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

google, scholar, laminin, cell, tumor, cells, cancer, martin, basement, kleinman, membrane, res, human, peptide, article, synthetic, biol, growth, matrigel, yamada, usa, metastasis, sequence, liotta, biochem, iwamoto, sci, metastatic, collagenase, acad, natl, invasion, chain, melanoma, mice, access, matrix, sasaki, proc, robey, privacy, cookies, content, zain, fridman, activity, models, role, extracellular, rao,

Topics {✒️}

tyr-ile-gly-ser-arg cell adhesive arg-gly-asp month download article/chapter extracellular matrix interactions full-length cdna encoding synthetic peptide derived extracellular matrix arg-gly-asp metastasis reviews aims experimental cancer metastasis cell-matrix interactions promote angiogenesis basement membrane components reconstituted basement membrane matrix-mediated motility full article pdf privacy choices/manage cookies type iv collagenase human colon carcinoma basement membrane complexes basement membrane proteins tumor cell lines b16f10 melanoma cells laminin peptide f-9 type iv collagen 3t3-l1 cells growth factor activity human carcinoma cells collagenase iv production human endothelial cells adhesive protein concentrated tumor cell attachment cell adhesion molecules murine lung metastases human prostate cancer b16f10 tumor cells 3ll tumor cells enhanced tumor growth european economic area studying therapeutic agents check access increased mrna expression serum free medium instant access laminin related peptides murine tumor cells measure cell invasiveness conditions privacy policy acad sci 513 tumor cell invasion

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Basement membrane and the SIKVAV laminin-derived peptide promote tumor growth and metastases
         description:Laminin, the major glycoprotein component of basement membrane, promotes the malignant phenotype. Cells which are adherent to laminin are more malignant than the non-adherent cells and in certain tumor cells, the number of laminin receptors is positively correlated with malignancy. Laminin also increases collagenase IV activity, an enzyme demonstrated to be critical for tumor spread. A site on laminin, containing the amino acid sequence SIKVAV, has been identified which when injected intravenously with B16F10 melanoma cells, causes an increase in the number of colonies on the surface of the lungs. This peptide does not affect tumor cell arrest in the vasculature or the immune system. It does promote angiogenesis in various in vitro and in vivo models, thereby facilitating tumor cell survival. When a complex mixture of laminin-enriched basement membrane components (Matrigel) is coinjected with tumor cells subcutaneously, tumor incidence and growth increases. Various tumor cell lines and primary isolates, which previously could not form tumors in mice, can be induced to grow rapidly in the presence of Matrigel. Slowly growing tumors or arrested tumors can also be induced to grow more quickly with additional injections of Matrigel. When an SIKVAV-containing synthetic peptide is coinjected with B16F10 tumor cells and Matrigel subcutaneously in mice, larger tumors are formed than that observed with either Matrigel or cells alone. Such studies define the role of laminin in tumor growth and spread and generate new models for studying therapeutic agents. Of particular interest is the ability to grow primary isolates which generally do not grow in mice.
         datePublished:
         dateModified:
         pageStart:245
         pageEnd:254
         sameAs:https://doi.org/10.1007/BF00050795
         keywords:
            laminin
            basement membrane
            synthetic peptide
            extracellular matrix
            collagenase
            metastasis
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
               0167-7659
            volumeNumber:10
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Kluwer Academic Publishers
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Thomas M. Sweeney
               affiliation:
                     name:National Institutes of Health
                     address:
                        name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maura C. Kibbey
               affiliation:
                     name:National Institutes of Health
                     address:
                        name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mona Zain
               affiliation:
                     name:National Institutes of Health
                     address:
                        name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rafael Fridman
               affiliation:
                     name:Molecular Oncology, Inc.
                     address:
                        name:Molecular Oncology, Inc., Gaithersburg, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hynda K. Kleinman
               affiliation:
                     name:National Institutes of Health
                     address:
                        name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Basement membrane and the SIKVAV laminin-derived peptide promote tumor growth and metastases
      description:Laminin, the major glycoprotein component of basement membrane, promotes the malignant phenotype. Cells which are adherent to laminin are more malignant than the non-adherent cells and in certain tumor cells, the number of laminin receptors is positively correlated with malignancy. Laminin also increases collagenase IV activity, an enzyme demonstrated to be critical for tumor spread. A site on laminin, containing the amino acid sequence SIKVAV, has been identified which when injected intravenously with B16F10 melanoma cells, causes an increase in the number of colonies on the surface of the lungs. This peptide does not affect tumor cell arrest in the vasculature or the immune system. It does promote angiogenesis in various in vitro and in vivo models, thereby facilitating tumor cell survival. When a complex mixture of laminin-enriched basement membrane components (Matrigel) is coinjected with tumor cells subcutaneously, tumor incidence and growth increases. Various tumor cell lines and primary isolates, which previously could not form tumors in mice, can be induced to grow rapidly in the presence of Matrigel. Slowly growing tumors or arrested tumors can also be induced to grow more quickly with additional injections of Matrigel. When an SIKVAV-containing synthetic peptide is coinjected with B16F10 tumor cells and Matrigel subcutaneously in mice, larger tumors are formed than that observed with either Matrigel or cells alone. Such studies define the role of laminin in tumor growth and spread and generate new models for studying therapeutic agents. Of particular interest is the ability to grow primary isolates which generally do not grow in mice.
      datePublished:
      dateModified:
      pageStart:245
      pageEnd:254
      sameAs:https://doi.org/10.1007/BF00050795
      keywords:
         laminin
         basement membrane
         synthetic peptide
         extracellular matrix
         collagenase
         metastasis
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
            0167-7659
         volumeNumber:10
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Kluwer Academic Publishers
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Thomas M. Sweeney
            affiliation:
                  name:National Institutes of Health
                  address:
                     name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maura C. Kibbey
            affiliation:
                  name:National Institutes of Health
                  address:
                     name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mona Zain
            affiliation:
                  name:National Institutes of Health
                  address:
                     name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rafael Fridman
            affiliation:
                  name:Molecular Oncology, Inc.
                  address:
                     name:Molecular Oncology, Inc., Gaithersburg, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hynda K. Kleinman
            affiliation:
                  name:National Institutes of Health
                  address:
                     name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:10
Organization:
      name:Kluwer Academic Publishers
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Institutes of Health
      address:
         name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:National Institutes of Health
      address:
         name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:National Institutes of Health
      address:
         name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:Molecular Oncology, Inc.
      address:
         name:Molecular Oncology, Inc., Gaithersburg, USA
         type:PostalAddress
      name:National Institutes of Health
      address:
         name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Thomas M. Sweeney
      affiliation:
            name:National Institutes of Health
            address:
               name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Maura C. Kibbey
      affiliation:
            name:National Institutes of Health
            address:
               name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Mona Zain
      affiliation:
            name:National Institutes of Health
            address:
               name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Rafael Fridman
      affiliation:
            name:Molecular Oncology, Inc.
            address:
               name:Molecular Oncology, Inc., Gaithersburg, USA
               type:PostalAddress
            type:Organization
      name:Hynda K. Kleinman
      affiliation:
            name:National Institutes of Health
            address:
               name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
      name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
      name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
      name:Molecular Oncology, Inc., Gaithersburg, USA
      name:Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(91)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.65s.

LINK . SPRINGER . COM {}