JCS . BIOLOGISTS . ORG {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Jcs.biologists.org Make Money
Keywords
Topics
Payment Methods
Questions
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
CDN Services

We are analyzing https://jcs.biologists.org/cgi/doi/10.1242/jcs.03355.

Title:
Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β | Journal of Cell Science | The Company of Biologists
Description:
Lamin B receptor (LBR), a chromatin and lamin binding protein in the inner nuclear membrane, has been proposed to play a vital role in nuclear envelope (NE) assembly. But the specific role for LBR in NE assembly remains unknown. In the present study, we show that overexpression of LBR causes membrane overproduction, inducing NE invagination and membrane stack formation, and that these processes require the transmembrane domain of LBR. Biochemical analysis shows that the N-terminal domain of LBR directly interacts with importin β in a Ran sensitive and importin α independent manner. Using an in vitro NE assembly assay, we also demonstrate that blocking full length LBR binding sites on importin β, by the addition of the LBR N-terminal domain inhibits the recruitment of LBR-containing vesicles to importin β- or Ran-coated beads to form NE structure. Our results suggest that LBR is recruited to chromatin through direct interaction with importin β to contribute to the fusion of membrane vesicles and formation of the NE.
Website Age:
27 years and 8 months (reg. 1997-11-05).

Matching Content Categories {📚}

Science
Education
Crafts

Content Management System {📝}

What CMS is jcs.biologists.org built with?

Custom-built

No common CMS systems were detected on Jcs.biologists.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of jcs.biologists.org audience?

🚄 Respectable Traffic: 10k - 20k visitors per month

Based on our best estimate, this website will receive around 17,059 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Jcs.biologists.org Make Money? {💸}

We can't figure out the monetization strategy.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Jcs.biologists.org could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

importin, lbr, nuclear, assembly, membrane, gfpxlbr, binding, cell, beads, extract, cells, fig, ran, protein, hela, chromatin, proteins, xlbr, vesicles, zhang, hisxlbr, lamin, interaction, biol, receptor, envelope, domain, xenopus, mitotic, recruitment, human, antibody, assay, clarke, gstimportin, aggregates, amino, purified, βcoated, precursor, worman, buffer, egg, presence, incubated, results, nterminal, vitro, sites, acids,

Topics {✒️}

cnbr-activated sepharose 4b-coated open menu cdna library gfp-lbr-expressing cells show multiple serine-arginine motifs human pelger-huet anomaly fast-tracked decision making stably expresses gfp-xlbr full-length gfp-xlbr full length gfp-xlbr hydrophilic n-terminal domain isopropyl-β-d-thiogalactopyranoside share common signals n-terminal domains project n-terminal deletion constructs jcs fast-track option gfp-xlbr211-621-expressing cells full-length importin β truncated n-terminal domains cell science journal transmission electron microscopy c-terminal deletion mutants domain-presenting expression system gfp-xlbr expression vector anti-ha-tag antibody purified n-terminal domain sds-page loading buffer human cell-free system importin β-binding signal importin β-coated beads importin α-independent manner arginine-rich domains present hela cells expressing importin β-depleted system added rangdp-coated beads cold spring harbor gst-importin β bound gst-importin β-bound importin β-depleted extract gst-importin β45-876-bound transiently expressed gfp-xlbr nuclear localization signals nuclear localization signal crude egg extract purified gst-importin β anti-importin β antibody company limited full length xlbr importin α/β pathway mouse ichthyosis locus

Payment Methods {📊}

Stripe

Questions {❓}

Have a paper that has been reviewed elsewhere?
Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?
The inner nuclear membrane: simple, or very complex?

Schema {🗺️}

ScholarlyArticle:
      context:https://schema.org
      id:https://journals.biologists.com/jcs/article/120/3/520/29826/Lamin-B-receptor-plays-a-role-in-stimulating
      name:Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β
      datePublished:2007-02-01
      isPartOf:
         id:https://journals.biologists.com/jcs/issue/120/3
         type:PublicationIssue
         issueNumber:3
         datePublished:2007-02-01
         isPartOf:
            id:https://journals.biologists.com/jcs
            type:Periodical
            name:Journal of Cell Science
            issn:
               1477-9137
      url:https://dx.doi.org/10.1242/jcs.03355
      keywords:
         Nuclear envelope assembly
         Lamin B receptor
         Importin β
         Ran GTPase
      inLanguage:en
      copyrightHolder:
      copyrightYear:2025
      publisher:
      author:
            name:Ma, Yan
            affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
            type:Person
            name:Cai, Shang
            affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
            type:Person
            name:Lv, Quanlong
            affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
            type:Person
            name:Jiang, Qing
            affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
            type:Person
            name:Zhang, Quan
            affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
            type:Person
            name:, Sodmergen
            affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
            type:Person
            name:Zhai, Zhonghe
            affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
            type:Person
            name:Zhang, Chuanmao
            affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
            type:Person
      description:Lamin B receptor (LBR), a chromatin and lamin binding protein in the inner nuclear membrane, has been proposed to play a vital role in nuclear envelope (NE) assembly. But the specific role for LBR in NE assembly remains unknown. In the present study, we show that overexpression of LBR causes membrane overproduction, inducing NE invagination and membrane stack formation, and that these processes require the transmembrane domain of LBR. Biochemical analysis shows that the N-terminal domain of LBR directly interacts with importin β in a Ran sensitive and importin α independent manner. Using an in vitro NE assembly assay, we also demonstrate that blocking full length LBR binding sites on importin β, by the addition of the LBR N-terminal domain inhibits the recruitment of LBR-containing vesicles to importin β- or Ran-coated beads to form NE structure. Our results suggest that LBR is recruited to chromatin through direct interaction with importin β to contribute to the fusion of membrane vesicles and formation of the NE.
      pageStart:520
      pageEnd:530
      siteName:The Company of Biologists
      thumbnailURL:https://cob.silverchair-cdn.com/cob/content_public/journal/jcs/issue/120/3/3/m_joces_120_3_cover.png?Expires=1814635417&Signature=4NgBweV5fmS-DaMbSldwxVl2uqzlcp9O96sS67FtkI6aOVOfsjnI5iJnGcYS3kpvrjmz64mczcUOMyyZz3fZqFPQPeUCCLQ07pXOp7lykQPv~5k67l0DcdSqfW4X8vmXPtdsD6K2KxQPie9hh8rMW7ctWc41WJ5ebxqq-ZXDZkuoDFAFvdIWnHH28Qv~UGHojzzUzVZYQ9rDhPef4QlRknJbIxpEk8Qnvj7hY0y2PJ7113lQmv6AZQEVf4jILtp7tAANEPvOOHqIci-4ogPgzxO1UV~vIE15nqyBc9JhdfcmXc488D2gTmCmdJ7cPNg0Pk5JHckypwiIoh8ERQzMvw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
      headline:Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β
      image:https://cob.silverchair-cdn.com/cob/content_public/journal/jcs/issue/120/3/3/m_joces_120_3_cover.png?Expires=1814635417&Signature=4NgBweV5fmS-DaMbSldwxVl2uqzlcp9O96sS67FtkI6aOVOfsjnI5iJnGcYS3kpvrjmz64mczcUOMyyZz3fZqFPQPeUCCLQ07pXOp7lykQPv~5k67l0DcdSqfW4X8vmXPtdsD6K2KxQPie9hh8rMW7ctWc41WJ5ebxqq-ZXDZkuoDFAFvdIWnHH28Qv~UGHojzzUzVZYQ9rDhPef4QlRknJbIxpEk8Qnvj7hY0y2PJ7113lQmv6AZQEVf4jILtp7tAANEPvOOHqIci-4ogPgzxO1UV~vIE15nqyBc9JhdfcmXc488D2gTmCmdJ7cPNg0Pk5JHckypwiIoh8ERQzMvw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
      image:alt:Issue Cover
PublicationIssue:
      id:https://journals.biologists.com/jcs/issue/120/3
      issueNumber:3
      datePublished:2007-02-01
      isPartOf:
         id:https://journals.biologists.com/jcs
         type:Periodical
         name:Journal of Cell Science
         issn:
            1477-9137
Periodical:
      id:https://journals.biologists.com/jcs
      name:Journal of Cell Science
      issn:
         1477-9137
Person:
      name:Ma, Yan
      affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
      name:Cai, Shang
      affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
      name:Lv, Quanlong
      affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
      name:Jiang, Qing
      affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
      name:Zhang, Quan
      affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
      name:, Sodmergen
      affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
      name:Zhai, Zhonghe
      affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China
      name:Zhang, Chuanmao
      affiliation:The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, The National Key Laboratory of Bio-membrane and Membrane Biotechnology, the College of Life Sciences, Peking University, Beijing 100871, China

Social Networks {👍}(7)

External Links {🔗}(70)

Analytics and Tracking {📊}

Google Analytics
Google Analytics 4
Google Tag Manager
Google Universal Analytics

Libraries {📚}

jQuery
Sharethis
Video.js

CDN Services {📦}

Com/cob/content_public/journal/jcs/120/3/10
Com/cob/content_public/journal/jcs/issue/120/3/3/m_joces_120_3_cover
Com/data/SiteBuilderAssets/Live/CSS/jcs/v-638761620424299800/site
Com/data/SiteBuilderAssets/Live/Images/jcs/apple-touch-icon1853126287
Com/data/SiteBuilderAssets/Live/Images/jcs/favicon-16x16-203215716
Com/data/SiteBuilderAssets/Live/Images/jcs/favicon-32x32-1588085212
Com/data/SiteBuilderAssets/Live/Images/jcs/favicon-1720491505
Com/data/SiteBuilderAssets/Live/Images/jcs/JCS_footer-1181661556
Com/data/SiteBuilderAssets/Live/Images/jcs/JCS_title_cropped1117566901
Com/data/SiteBuilderAssets/Live/Images/jcs/safari-pinned-tab975650023
Com/DownloadFile/DownloadImage
Com/ImageLibrary/CoB_100_white-logo-lock-up_AW_RGB_FC_small3
Com/ImageLibrary/Development/Snippets/JCS-SI-Cell-Biology-of-Mitochondria-600x230SnippetBanner
Com/ImageLibrary/JCellScience/Snippets/0625-JCS-Snippet-mitrochondrialinnermembranecomposition
Com/ImageLibrary/JCellScience/Snippets/JCS-2026-Meeting-600x230-Snippet
Com/ImageLibrary/JCellScience/Snippets/JCS_FastTrack_Snippet_600x230_02
Com/ImageLibrary/JournalsGateway/Bluesky-icon
Com/ImageLibrary/JournalsGateway/Bluesky-icon-bw
Com/ImageLibrary/JournalsGateway/facebook-icon
Com/ImageLibrary/JournalsGateway/instagram-icon
Com/ImageLibrary/JournalsGateway/rss-icon
Com/ImageLibrary/JournalsGateway/x-icon
Com/ImageLibrary/JournalsGateway/youtube-icon
Com/ImageLibrary/Mastodon_Social_Icon_Circle_BW_TransparencyNoBlk
Com/ImageLibrary/wechat-white-transparent-noring
Com/Themes/Client/app/css/v-638848468170862866/bg_img
Com/Themes/Client/app/css/v-638870643329214546/site
Com/Themes/Client/app/jsdist/v-638870643450811692/site
Com/Themes/Silver/app/icons/v-638848469864512582/style
Com/Themes/Silver/app/js/jquery
Com/Themes/Silver/app/vendor/v-638848469881376018/jquery-migrate-3
Com/UI/app/svg/umbrella/logo
Cookiepro
Jsdelivr

8.92s.