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We began analyzing https://www.nature.com/articles/s41598-021-81418-x, but it redirected us to https://www.nature.com/articles/s41598-021-81418-x. The analysis below is for the second page.

Title[redir]:
Comparison of apoptotic responses in Blastocystis sp. upon treatment with Tongkat Ali and Metronidazole | Scientific Reports
Description:
Blastocystis sp. infection, although many remain asymptomatic, there is growing data in recent studies that suggests it is a frequent cause of gastrointestinal symptoms in children and adults. This proposes that treatment against this infection is necessary however metronidazole (MTZ), which is the current choice of treatment, has expressed non-uniformity in its efficacy in combating this infection which has led to the study of alternative treatment. In our previous study, it was established that Tongkat Ali fractions exhibited promising anti-protozoal properties which leads to the current aim of the study, to further narrow down the purification process in order to identify the specific active compound promoting the anti-protozoal effect through HPLC analysis. Based on the data analysis and in-vitro susceptibility assay, the collected Tongkat Ali fraction that demonstrated anti-blastocystis property was shown to contain eurycomanone. Previous studies have suggested that there is a mechanism in Blastocystis sp. that regulates the apoptotic process to produce higher number of viable cells when treated. In reference to this, our current study also aims to investigate the apoptotic response of Tongkat Ali extract and eurycomanone across different subtype groups with comparison to MTZ. Based on our investigation, both Tongkat Ali extract and eurycomanone induced the high apoptotic rate however exhibited a reduction in viable cell count (p < 0.05) when compared to MTZ. This study suggests that there is potential in developing a standardized treatment regardless of subtype variations which makes Tongkat Ali extract a promising anti-protozoal treatment against all Blastocystis sp. subtype groups.

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Keywords {🔍}

cells, blastocystis, article, cell, apoptosis, apoptotic, google, scholar, pubmed, study, cas, mtz, treatment, tongkat, ali, treated, extract, antiprotozoal, eurycomanone, nature, viable, death, eurycoma, longifolia, analysis, rate, mgml, stained, subtype, activity, number, data, mechanism, count, observed, full, size, bcl, protein, response, image, figure, responses, infection, compound, based, fraction, higher, results, necrotic,

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nature portfolio nature 391 nature author information authors spd-20a uv–vis detector stock solutions mitosis research proteomics research additional information publisher' minor-groove-binding dna stain reprints japan hypothalamic-pituitary-gonadal axis promising anti-protozoal agent anti-protozoal promoting compound medical ethics committee tandem mass spectrometry mitogen-activated protein kinase mitogen-activated protein kinases highest anti-protozoal activity vitro anti-tumor promoting promising anti-protozoal treatment efficient anti-protozoal agent full size image author correspondence original author human-derived blastocystis sp 1hnmr-based discriminatory analysis drug development demonstrated anti-blastocystis property induces pro-inflammatory cytokines medical biotechnology laboratory anti-protozoal property previously published paper24 anti-protozoal activity anti-cancer properties drug discovery spectral data based metronidazole sonal girish human intestinal protozoa current data coincides anti-protozoal effect explore content similar content methods parasite culture anti-pathogenic properties permissions anti-bacterial properties21 article girish image analyser software

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