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We began analyzing https://www.nature.com/articles/4400393, but it redirected us to https://www.nature.com/articles/4400393. The analysis below is for the second page.

Title[redir]:
Prohibitin and RACK homologues are up-regulated in trypanosomes induced to undergo apoptosis and in naturally occurring terminally differentiated forms | Cell Death & Differentiation
Description:
Two genes have been identified as up-regulated late during ConA-induced apoptosis in procyclic form Trypanosoma brucei rhodesiense. The first represents a homologue of prohibitin, a proto-oncogene originally described in mammals and subsequently in yeast, which is involved in cell-cycle control and senescence. The Trypanosoma prohibitin homologue appears to contain within it a putative death domain. The second gene, homologous to a family of regulatory proteins which are receptors for activated protein kinase C (RACKs), is also shown to be up-regulated in terminally differentiated bloodstream form trypanosomes. These are the first endogenous genes to be identified as up-regulated in programmed cell death (PCD) in unicellular organisms.

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Keywords {🔍}

nature, cell, article, death, prohibitin, research, content, trypanosoma, upregulated, apoptosis, open, differentiation, welburn, access, information, permissions, july, rack, trypanosomes, terminally, differentiated, susan, murphy, brucei, gene, programmed, expression, pdf, author, rights, privacy, advertisement, journals, original, paper, published, homologues, induced, undergo, naturally, occurring, forms, noel, cite, abstract, genes, identified, form, rhodesiense, homologue,

Topics {✒️}

nature portfolio permissions reprints nature tsetse research group programmed cell death trypanosoma cruzi induce gene expression hallmarks tissue research cell death pathways cell death differ putative death domain cona-induced apoptosis cell-cycle control cell-signaling pathways explore content similar content rack homologues permissions content journals search log proto-oncogene originally activated protein kinase stepwise developmental progression ubiquitin-related processes active nuclear transport mutations synthetic-lethal gene undergo apoptosis knight rights article welburn https miltefosine-sensitive thompson cell article cite article //doi cookies trypanosomes induced kenya susan uk susan prohibitin journal publish welburn & noel regulatory proteins unicellular organisms negative regulators 2023 metacyclogenesis defects welburn division molecular genetics life sciences

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         datePublished:1998-07-10T00:00:00Z
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      headline:Prohibitin and RACK homologues are up-regulated in trypanosomes induced to undergo apoptosis and in naturally occurring terminally differentiated forms
      description:Two genes have been identified as up-regulated late during ConA-induced apoptosis in procyclic form Trypanosoma brucei rhodesiense. The first represents a homologue of prohibitin, a proto-oncogene originally described in mammals and subsequently in yeast, which is involved in cell-cycle control and senescence. The Trypanosoma prohibitin homologue appears to contain within it a putative death domain. The second gene, homologous to a family of regulatory proteins which are receptors for activated protein kinase C (RACKs), is also shown to be up-regulated in terminally differentiated bloodstream form trypanosomes. These are the first endogenous genes to be identified as up-regulated in programmed cell death (PCD) in unicellular organisms.
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