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Title[redir]:
Four deaths and a funeral: from caspases to alternative mechanisms | Nature Reviews Molecular Cell Biology
Description:
A single family of proteases, the caspases, has long been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionarily conserved, caspase-independent controlled death mechanisms have opened new perspectives on the biology of cell demise, with particular implications for neurobiology, cancer research and immunological processes.
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pubmed, cell, article, google, scholar, cas, death, apoptosis, central, nature, caspaseindependent, cells, biol, caspases, cancer, activation, necrosis, programmed, proteases, pathway, time, neuronal, caspase, sci, protein, pcd, induced, acad, mitochondrial, jäättelä, nuclear, activity, apoptotic, factor, necrotic, leist, morphology, cathepsin, blebbing, proc, natl, usa, neurosci, chromatin, pathways, receptors, access, movie, lapse, recorded,
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examples include z-val-ala-asp-fluoromethylkethone nature portfolio author information authors il-1β-converting enzyme/ced-3 proteases bcl-2 homologue bak permissions reprints fadd/caspase-dependent signaling pathway tnf-α-mediated hepatocyte apoptosis ced-3/ice-related proteases german research council tumor necrosis factor-α p53-dependent caspase activation induces p53-independent apoptosis tnf-induced caspase-dependent death orp150 protects age-related macular degeneration hypoxia/ischemia-induced neuronal death catalyses atp-dependent auto-activation nature cell biol cancer research death-receptor-induced necrotic pathway fadd/caspase signaling pten bax-induced cell death nature rev adapter protein daxx fas antigen-mediated pathway daxx-mediated apoptosis retard caspase-dependent processes tnf-α caspase-independent cell killing nature genet chemotherapy-induced cell death salmonella-induced cell death caspase-independent cell death tumor-specific death program nature med caspase-dependent cdk activity nature immunol caspase-independent death pathways rock 'n' bleb cystatin b-deficient mice oligomycin-induced passive formation caspase-independent death process springerlink instant access jnk/p38 map kinases anti-apoptotic function downstream key regulatory step nature 407 nature 401
Questions {❓}
- Calpain and caspase: can you tell the difference?
- Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?
- Salmonella-induced cell death: apoptosis, necrosis or programmed cell death?
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A single family of proteases, the caspases, has long been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionarily conserved, caspase-independent controlled death mechanisms have opened new perspectives on the biology of cell demise, with particular implications for neurobiology, cancer research and immunological processes.
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